ES2112955T3 - Procedimiento de sintesis de peptidos y nuevos productos intermedios de sintesis. - Google Patents

Procedimiento de sintesis de peptidos y nuevos productos intermedios de sintesis.

Info

Publication number
ES2112955T3
ES2112955T3 ES93200690T ES93200690T ES2112955T3 ES 2112955 T3 ES2112955 T3 ES 2112955T3 ES 93200690 T ES93200690 T ES 93200690T ES 93200690 T ES93200690 T ES 93200690T ES 2112955 T3 ES2112955 T3 ES 2112955T3
Authority
ES
Spain
Prior art keywords
synthesis
peptides
new intermediate
products
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93200690T
Other languages
English (en)
Inventor
Marc Anteunis
Frank Becu
Roland Callens
Georges Blondeel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Solvay SA
Original Assignee
Solvay SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay SA filed Critical Solvay SA
Application granted granted Critical
Publication of ES2112955T3 publication Critical patent/ES2112955T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)

Abstract

PROCESO DE SINTESIS DE PEPTIDOS QUE CONTIENEN UNO O VARIOS RESTOS DE AMINOACIDOS QUE COMPRENDE UNA FUNCION N-CARBAMOILO, POR AMINOLISIS DE DERIVADOS N-ARILOXICARBONILO, EXCELENTES INTERMEDIARIOS DE SINTESIS PARA LA PREPARACION DE PEPTIDOS DIVERSOS INCLUYENDO RESTOS DE AMINOACIDOS QUE COMPRENDEN UN GRUPO UREINO, TALES COMO RESTOS CITRULINA, HOMOCITRULINA, 2-AMINO-4UREIDO-BUTIRICO.
ES93200690T 1992-03-20 1993-03-10 Procedimiento de sintesis de peptidos y nuevos productos intermedios de sintesis. Expired - Lifetime ES2112955T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BE9200273A BE1005720A3 (fr) 1992-03-20 1992-03-20 Procede de synthese peptidique et nouveaux intermediaires de synthese.

Publications (1)

Publication Number Publication Date
ES2112955T3 true ES2112955T3 (es) 1998-04-16

Family

ID=3886195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93200690T Expired - Lifetime ES2112955T3 (es) 1992-03-20 1993-03-10 Procedimiento de sintesis de peptidos y nuevos productos intermedios de sintesis.

Country Status (12)

Country Link
US (2) US5770692A (es)
EP (1) EP0562659B1 (es)
JP (1) JP3436559B2 (es)
AT (1) ATE161269T1 (es)
AU (1) AU664243B2 (es)
BE (1) BE1005720A3 (es)
CA (1) CA2092062C (es)
DE (1) DE69315730T2 (es)
ES (1) ES2112955T3 (es)
HU (1) HU221619B1 (es)
IL (1) IL105036A (es)
SG (1) SG64917A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1007184A3 (fr) * 1993-06-18 1995-04-18 Solvay Procede de preparation d'un amide d'alpha-aminoacide, utilisable en synthese peptidique.
SE9401079L (sv) * 1994-03-30 1995-10-01 Anders Unden Nya derivat av asparaginsyra och glutaminsyra som är skyddade på sidokedjans karboxylsyragrupp form av estrar som försvårar aspartimidbildning vid fastfassyntes av peptider
US6160122A (en) * 1996-06-28 2000-12-12 Abbott Laboratories Process for the preparation of a disubstituted thiazole
US6022989A (en) * 1996-06-28 2000-02-08 Abbott Laboratories Process for the preparation of an activated amino acid
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
JPWO2015030106A1 (ja) * 2013-09-02 2017-03-02 国立大学法人京都大学 Ｇｇｔ阻害作用を有する化合物及びｇｇｔファミリー酵素阻害剤
WO2023085342A1 (ja) * 2021-11-10 2023-05-19 長瀬産業株式会社 ＳａｐＢタンパク質の修飾体、ＳａｐＢタンパク質およびその修飾体の調製方法、並びにＳａｐＢタンパク質またはその修飾体を溶解した水溶液

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR36360B (el) * 1966-02-04 1969-02-03 J. R. Geigy A.G. Μεθοδος δια την παρασκευην νεων εστερων του αμινοκαρβονικου οξεος.
DE1963734A1 (de) * 1969-12-19 1971-06-24 Bayer Ag Harnstoffderivate von Acylderivaten des KTI
JPS58198497A (ja) * 1982-05-14 1983-11-18 Kowa Co 新規アミノ配糖体及びその製法
FR2573765B1 (fr) * 1984-11-23 1988-06-10 Solvay Procede pour la synthese de peptides
US4800191A (en) * 1987-07-17 1989-01-24 Schally Andrew Victor LHRH antagonists
DE3918057C1 (es) * 1989-06-02 1990-05-03 Degussa Ag, 6000 Frankfurt, De

Also Published As

Publication number Publication date
US5965770A (en) 1999-10-12
AU3524993A (en) 1993-09-23
US5770692A (en) 1998-06-23
JP3436559B2 (ja) 2003-08-11
CA2092062C (fr) 2003-08-05
SG64917A1 (en) 1999-05-25
EP0562659A1 (fr) 1993-09-29
HU9300799D0 (en) 1993-07-28
AU664243B2 (en) 1995-11-09
DE69315730D1 (de) 1998-01-29
DE69315730T2 (de) 1998-07-02
HUT65752A (en) 1994-07-28
IL105036A (en) 1998-06-15
HU221619B1 (hu) 2002-12-28
EP0562659B1 (fr) 1997-12-17
BE1005720A3 (fr) 1993-12-28
ATE161269T1 (de) 1998-01-15
JPH0641188A (ja) 1994-02-15
IL105036A0 (en) 1993-07-08
CA2092062A1 (fr) 1993-09-21

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