ES2111072T3 - Sistemas de extrusion de capsulas. - Google Patents
Sistemas de extrusion de capsulas.Info
- Publication number
- ES2111072T3 ES2111072T3 ES92914689T ES92914689T ES2111072T3 ES 2111072 T3 ES2111072 T3 ES 2111072T3 ES 92914689 T ES92914689 T ES 92914689T ES 92914689 T ES92914689 T ES 92914689T ES 2111072 T3 ES2111072 T3 ES 2111072T3
- Authority
- ES
- Spain
- Prior art keywords
- coagulant
- casting solution
- extruded
- extrusion
- delivery
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0613—Cells from endocrine organs
- C12N5/0614—Adrenal gland
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Preparation (AREA)
- Formation And Processing Of Food Products (AREA)
- General Preparation And Processing Of Foods (AREA)
- Dental Preparations (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Materials For Medical Uses (AREA)
Abstract
SE PRESENTAN METODOS PARA PRODUCIR CAPSULAS DE CELULAS EN LOS CUALES UN COAGULANTE (22), QUE PUEDE INCLUIR UNA SUSPENSION DE CELULAS U OTRO FACTOR BIOLOGICAMENTE ACTIVO, Y UNA SOLUCION POLIMERICA DE MOLDEADO (26) SON EXTRUDIDOS A TRAVES DE UN PUERTO COMUN DE EXTRUSION (14) QUE TIENE AL MENOS DOS ORIFICIOS CONCENTRICOS, DE FORMA QUE EL COAGULANTE ES EXTRUDIDO A TRAVES DEL ORIFICIO INTERIOR (16) Y LA SOLUCION POLIMERICA DE MOLDEADO SE EXTRUYE A TRAVES DEL ORIFICIO EXTERIOR (18). EL METODO COMPRENDE LA INICIACION DE LA EXTRUSION DEL COAGULANTE DENTRO DE UNA BANDA TEMPORAL DE ALREDEDOR DE 10 MILISEGUNDOS HASTA ALREDEDOR DE UN SEGUNDO DESDE EL SUMINISTRO INICIAL DE LA SOLUCION DE MOLDEADO A TRAVES DE LOS ORIFICIOS RESPECTIVOS. EL SUMINISTRO DEL COAGULANTE SE CORTA POSTERIORMENTE, Y LA EXTRUSION DE LA SOLUCION MOLDEADORA SE TERMINA TANTO INMEDIATAMENTE COMO DESPUES DE UN TIEMPO PREDETERMINADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72285291A | 1991-06-28 | 1991-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2111072T3 true ES2111072T3 (es) | 1998-03-01 |
Family
ID=24903670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92914689T Expired - Lifetime ES2111072T3 (es) | 1991-06-28 | 1992-06-25 | Sistemas de extrusion de capsulas. |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP0546158B1 (es) |
JP (1) | JPH06502120A (es) |
KR (1) | KR930701142A (es) |
AT (1) | ATE161707T1 (es) |
AU (1) | AU661021B2 (es) |
CA (1) | CA2090118A1 (es) |
DE (1) | DE69223932T2 (es) |
DK (1) | DK0546158T3 (es) |
ES (1) | ES2111072T3 (es) |
FI (1) | FI930884A (es) |
GR (1) | GR3026555T3 (es) |
NO (1) | NO930714L (es) |
SG (1) | SG48815A1 (es) |
WO (1) | WO1993000063A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5786216A (en) * | 1987-11-17 | 1998-07-28 | Cytotherapeutics, Inc. | Inner-supported, biocompatible cell capsules |
US5800829A (en) * | 1991-04-25 | 1998-09-01 | Brown University Research Foundation | Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core |
ATE156344T1 (de) * | 1991-04-25 | 1997-08-15 | Univ Brown Res Found | Implantierbare, biokompatible immunisolator- trägersubstanz zum abgeben ausgesuchter, therapeutischer produkte |
EP0708670A4 (en) * | 1993-06-23 | 1998-07-01 | Cytotherapeutics Inc | METHOD AND APPARATUS FOR HERMETICALLY CLOSING IMPLANTABLE MEMBRANE ENCAPSULATING DEVICES |
DE19918325A1 (de) | 1999-04-22 | 2000-10-26 | Euro Celtique Sa | Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion |
AU2003283399B2 (en) * | 2002-11-15 | 2007-04-19 | Novartis Ag | Drug delivery system |
US7311861B2 (en) * | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
US7723086B2 (en) * | 2004-06-16 | 2010-05-25 | Agency For Science, Technology + Research | Apparatus for encapsulating cells |
US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
US9463426B2 (en) * | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
WO2008122965A2 (en) | 2007-04-04 | 2008-10-16 | Sigmoid Pharma Limited | Pharmaceutical cyclosporin compositions |
CA2685118C (en) | 2007-04-26 | 2016-11-01 | Sigmoid Pharma Limited | Manufacture of multiple minicapsules |
BRPI1012196B1 (pt) | 2009-05-18 | 2021-11-30 | Sublimity Therapeutics Limited | Composição compreendendo gotas de óleo |
CN102573802A (zh) | 2009-08-12 | 2012-07-11 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
GB201212010D0 (en) | 2012-07-05 | 2012-08-22 | Sigmoid Pharma Ltd | Formulations |
GB201319791D0 (en) | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
SI3215127T1 (sl) | 2014-11-07 | 2021-03-31 | Sublimity Therapeutics Limited DCU Alpha Innovation Campus | Sestavki, obsegajoči ciklosporin |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS518876B2 (es) * | 1972-10-03 | 1976-03-22 | ||
JPS59131355A (ja) * | 1983-01-17 | 1984-07-28 | 森下仁丹株式会社 | 多重軟カプセルの製法 |
FR2564734A1 (fr) * | 1984-05-25 | 1985-11-29 | Harman Mitchell | Moyens et procede pour administrer des medicaments |
US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
US4902450A (en) * | 1988-09-28 | 1990-02-20 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Multi-element spherical shell generation |
-
1992
- 1992-06-25 ES ES92914689T patent/ES2111072T3/es not_active Expired - Lifetime
- 1992-06-25 AU AU23028/92A patent/AU661021B2/en not_active Ceased
- 1992-06-25 EP EP92914689A patent/EP0546158B1/en not_active Expired - Lifetime
- 1992-06-25 WO PCT/US1992/005256 patent/WO1993000063A1/en active IP Right Grant
- 1992-06-25 DE DE69223932T patent/DE69223932T2/de not_active Expired - Fee Related
- 1992-06-25 CA CA002090118A patent/CA2090118A1/en not_active Abandoned
- 1992-06-25 AT AT92914689T patent/ATE161707T1/de not_active IP Right Cessation
- 1992-06-25 DK DK92914689T patent/DK0546158T3/da active
- 1992-06-25 KR KR1019930700558A patent/KR930701142A/ko not_active Application Discontinuation
- 1992-06-25 SG SG1996001963A patent/SG48815A1/en unknown
- 1992-06-25 JP JP5501599A patent/JPH06502120A/ja active Pending
-
1993
- 1993-02-26 NO NO93930714A patent/NO930714L/no unknown
- 1993-02-26 FI FI930884A patent/FI930884A/fi unknown
-
1998
- 1998-04-06 GR GR980400742T patent/GR3026555T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GR3026555T3 (en) | 1998-07-31 |
AU661021B2 (en) | 1995-07-13 |
SG48815A1 (en) | 1998-05-18 |
FI930884A0 (fi) | 1993-02-26 |
FI930884A (fi) | 1993-04-21 |
DK0546158T3 (da) | 1998-09-07 |
ATE161707T1 (de) | 1998-01-15 |
NO930714D0 (no) | 1993-02-26 |
AU2302892A (en) | 1993-01-25 |
DE69223932T2 (de) | 1998-05-28 |
DE69223932D1 (de) | 1998-02-12 |
CA2090118A1 (en) | 1992-12-29 |
EP0546158A1 (en) | 1993-06-16 |
NO930714L (no) | 1993-04-19 |
WO1993000063A1 (en) | 1993-01-07 |
KR930701142A (ko) | 1993-06-11 |
JPH06502120A (ja) | 1994-03-10 |
EP0546158B1 (en) | 1998-01-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2111072T3 (es) | Sistemas de extrusion de capsulas. | |
GR3018582T3 (en) | Cell encapsulating method and apparatus | |
MX9605678A (es) | Produccion de composiciones de sustancia activa en forma de una solucion solida de la sustancia activa en una matriz de polimero, y composiciones de sustancia activa producidas por este procedimiento. | |
HU9204033D0 (en) | Substituted benzimidazoles, method for producing them and their pharmaceutical application | |
NO912769D0 (no) | Avleveringssystem for medikamenter. | |
IS4148A (is) | Hliðstæð aðferð til framleiðslu á 1,5 Benzodiazepine afleiðum | |
SE8501111L (sv) | Sett att framstella en semipermeabel halfiber | |
MY108860A (en) | Bloodbag and method of making same | |
FR2704418B1 (fr) | Tube contenant un activateur de la coagulation du sang et son procede de preparation. | |
DE69022103D1 (de) | Verbindungssystem zwischen Haupteinheit und zusätzlichen Prozesseinheiten. | |
HUP9903538A2 (hu) | Oligoszacharidok alkalmazása szövetmembrán-elégtelenség kezelésére szolgáló gyógyászati készítmények előállítására | |
NO981864L (no) | Oppl°sningsmetoder | |
DE3481057D1 (de) | 2-sulfamoylbenzo(b)thiophen-derivate, ihre herstellung und pharmazeutische zubereitung zur behandlung von erhoehtem augeninnendruck. | |
HU9202358D0 (en) | Imidazo(2,1-b)benzothiazole-3-acetamide derivatives, method for producing them and pharmaceutical preparatives containing said components as active agents | |
NO953897L (no) | Fremgangsmåte for innkapsling av substanser i biokapsler | |
GEP19991819B (en) | Method for Production of Therapeutic Form of Carbamazepin with Retarded Active Substance Release | |
ITMI922243A0 (it) | Metodo per l'espressione nel lievito schizosaccharomyces pompe di recettori del sistema nervoso umano | |
ITPN950036A0 (it) | Procedimento ed impianto perfezionato per la produzione di corpi cavi in p.e.t. | |
DE69732307D1 (de) | Vorrichtung und verfahren zur herstellung von unterteilten rohrförmigen kapseln mit einer biologisch aktiven zusammensetzung | |
TH19570A (th) | วิธีการสำหรับการต่อต้านการจับตัวเป็นก้อนในการไหลเวียนที่อยู่ภายนอกร่างกายของเลือดและอุปกรณ์ของการปล่อยยาชนิดแอนตี้ธรอมโบติกที่ถูกใช้สำหรับส่วนที่เหมือนกันนี้ | |
HU9202540D0 (en) | Method for producing pharmaceutical preparatives containing new 1-benzo-pyrqno(4,3-c)pyrazole derivatives and their active agents | |
NO882411D0 (no) | Belegg paa basis av polyuretan, tokomponentsystem og fremgangsmaate for fremstilling derav. | |
ATE49599T1 (de) | 2-sulfamoylbenzo(b)thiophen-derivate, ihre herstellung und pharmazeutische zubereitung zur behandlung von erhoehtem augeninnendruck. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 546158 Country of ref document: ES |