ATE161707T1 - Kapselextrusionssysteme - Google Patents

Kapselextrusionssysteme

Info

Publication number
ATE161707T1
ATE161707T1 AT92914689T AT92914689T ATE161707T1 AT E161707 T1 ATE161707 T1 AT E161707T1 AT 92914689 T AT92914689 T AT 92914689T AT 92914689 T AT92914689 T AT 92914689T AT E161707 T1 ATE161707 T1 AT E161707T1
Authority
AT
Austria
Prior art keywords
coagulant
casting solution
extruded
extrusion
delivery
Prior art date
Application number
AT92914689T
Other languages
English (en)
Inventor
Patrick Aebischer
John F Mills
Lars Wahlberg
Edward J Doherty
Patrick A Tresco
Original Assignee
Univ Brown Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brown Res Found filed Critical Univ Brown Res Found
Application granted granted Critical
Publication of ATE161707T1 publication Critical patent/ATE161707T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0613—Cells from endocrine organs
    • C12N5/0614—Adrenal gland
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/30—Synthetic polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Medicinal Preparation (AREA)
  • Dental Preparations (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
AT92914689T 1991-06-28 1992-06-25 Kapselextrusionssysteme ATE161707T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72285291A 1991-06-28 1991-06-28

Publications (1)

Publication Number Publication Date
ATE161707T1 true ATE161707T1 (de) 1998-01-15

Family

ID=24903670

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92914689T ATE161707T1 (de) 1991-06-28 1992-06-25 Kapselextrusionssysteme

Country Status (14)

Country Link
EP (1) EP0546158B1 (de)
JP (1) JPH06502120A (de)
KR (1) KR930701142A (de)
AT (1) ATE161707T1 (de)
AU (1) AU661021B2 (de)
CA (1) CA2090118A1 (de)
DE (1) DE69223932T2 (de)
DK (1) DK0546158T3 (de)
ES (1) ES2111072T3 (de)
FI (1) FI930884A (de)
GR (1) GR3026555T3 (de)
NO (1) NO930714L (de)
SG (1) SG48815A1 (de)
WO (1) WO1993000063A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786216A (en) * 1987-11-17 1998-07-28 Cytotherapeutics, Inc. Inner-supported, biocompatible cell capsules
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
WO1992019195A1 (en) * 1991-04-25 1992-11-12 Brown University Research Foundation Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
EP0708670A4 (de) * 1993-06-23 1998-07-01 Cytotherapeutics Inc Verfahren und vorrichtung zum abdichten von implantierbaren membranen aufweisenden einkapselungsvorrichtungen
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
PL376169A1 (en) * 2002-11-15 2005-12-27 Novartis Ag Drug delivery system
US7311861B2 (en) * 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US7723086B2 (en) * 2004-06-16 2010-05-25 Agency For Science, Technology + Research Apparatus for encapsulating cells
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) * 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
WO2008122967A2 (en) 2007-04-04 2008-10-16 Sigmoid Pharma Limited An oral pharmaceutical composition
WO2008132707A1 (en) 2007-04-26 2008-11-06 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US9278070B2 (en) 2009-05-18 2016-03-08 Sigmoid Pharma Limited Composition comprising oil drops
EP2464341B1 (de) 2009-08-12 2022-07-06 Sublimity Therapeutics Limited Immunmodulatorische zusammensetzungen mit einer polymermatrix und einer ölphase
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
GB201212010D0 (en) 2012-07-05 2012-08-22 Sigmoid Pharma Ltd Formulations
GB201319791D0 (en) 2013-11-08 2013-12-25 Sigmoid Pharma Ltd Formulations
EA036036B1 (ru) 2014-11-07 2020-09-16 Сигмойд Фарма Лимитед Композиции, содержащие циклоспорин

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS518876B2 (de) * 1972-10-03 1976-03-22
JPS59131355A (ja) * 1983-01-17 1984-07-28 森下仁丹株式会社 多重軟カプセルの製法
FR2564734A1 (fr) * 1984-05-25 1985-11-29 Harman Mitchell Moyens et procede pour administrer des medicaments
US4892538A (en) * 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US4902450A (en) * 1988-09-28 1990-02-20 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Multi-element spherical shell generation

Also Published As

Publication number Publication date
EP0546158A1 (de) 1993-06-16
DK0546158T3 (da) 1998-09-07
ES2111072T3 (es) 1998-03-01
DE69223932T2 (de) 1998-05-28
EP0546158B1 (de) 1998-01-07
KR930701142A (ko) 1993-06-11
DE69223932D1 (de) 1998-02-12
AU661021B2 (en) 1995-07-13
NO930714L (no) 1993-04-19
GR3026555T3 (en) 1998-07-31
AU2302892A (en) 1993-01-25
FI930884A (fi) 1993-04-21
NO930714D0 (no) 1993-02-26
SG48815A1 (en) 1998-05-18
FI930884A0 (fi) 1993-02-26
CA2090118A1 (en) 1992-12-29
WO1993000063A1 (en) 1993-01-07
JPH06502120A (ja) 1994-03-10

Similar Documents

Publication Publication Date Title
ATE161707T1 (de) Kapselextrusionssysteme
GR3018582T3 (en) Cell encapsulating method and apparatus
DE69216642D1 (de) Verfahren zur herstellung von tabletten mit hoher festigkeit
MX9605678A (es) Produccion de composiciones de sustancia activa en forma de una solucion solida de la sustancia activa en una matriz de polimero, y composiciones de sustancia activa producidas por este procedimiento.
HU9204033D0 (en) Substituted benzimidazoles, method for producing them and their pharmaceutical application
NO912769L (no) Avleveringssystem for medikamenter.
MY108860A (en) Bloodbag and method of making same
SE8501111L (sv) Sett att framstella en semipermeabel halfiber
HUP9903538A2 (hu) Oligoszacharidok alkalmazása szövetmembrán-elégtelenség kezelésére szolgáló gyógyászati készítmények előállítására
DE3481057D1 (de) 2-sulfamoylbenzo(b)thiophen-derivate, ihre herstellung und pharmazeutische zubereitung zur behandlung von erhoehtem augeninnendruck.
NO953897L (no) Fremgangsmåte for innkapsling av substanser i biokapsler
GEP19991819B (en) Method for Production of Therapeutic Form of Carbamazepin with Retarded Active Substance Release
AU1789301A (en) Osmotic dosage form comprising first and second
ITMI922243A0 (it) Metodo per l'espressione nel lievito schizosaccharomyces pompe di recettori del sistema nervoso umano
IT1226638B (it) Procedimento per la realizzazione di granuli, in particolare granuli sferoidali, ed apparecchiatura per l'attuazione di tale metodo
PT98252A (pt) Dispositivo osmotico e processo para a administracao de um farmaco utilizando esse dispositivo para efectuar terapia circadiana
DE69732307D1 (de) Vorrichtung und verfahren zur herstellung von unterteilten rohrförmigen kapseln mit einer biologisch aktiven zusammensetzung
TH19570A (th) วิธีการสำหรับการต่อต้านการจับตัวเป็นก้อนในการไหลเวียนที่อยู่ภายนอกร่างกายของเลือดและอุปกรณ์ของการปล่อยยาชนิดแอนตี้ธรอมโบติกที่ถูกใช้สำหรับส่วนที่เหมือนกันนี้
HU9202540D0 (en) Method for producing pharmaceutical preparatives containing new 1-benzo-pyrqno(4,3-c)pyrazole derivatives and their active agents
ES2106495T3 (es) Mejoras en la eficacia de los medicamentos.
ATE49599T1 (de) 2-sulfamoylbenzo(b)thiophen-derivate, ihre herstellung und pharmazeutische zubereitung zur behandlung von erhoehtem augeninnendruck.
NO882411D0 (no) Belegg paa basis av polyuretan, tokomponentsystem og fremgangsmaate for fremstilling derav.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee