ES2110030T3 - Nuevos derivados de 17-hidroxiiminometil-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos. - Google Patents

Nuevos derivados de 17-hidroxiiminometil-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.

Info

Publication number
ES2110030T3
ES2110030T3 ES93110189T ES93110189T ES2110030T3 ES 2110030 T3 ES2110030 T3 ES 2110030T3 ES 93110189 T ES93110189 T ES 93110189T ES 93110189 T ES93110189 T ES 93110189T ES 2110030 T3 ES2110030 T3 ES 2110030T3
Authority
ES
Spain
Prior art keywords
processes
preparation
pharmaceutical compositions
hydroxyiminometil
androstano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93110189T
Other languages
English (en)
Inventor
Alberto Cerri
Luigi Bernardi
Giuseppe Bianchi
Monica Florio
Elena Folpini
Piero Melloni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of ES2110030T3 publication Critical patent/ES2110030T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

DERIVADOS DE 17-HIDROXIIMINOMETIL-14(BETA)-HIDROXI-5(BETA)-ANDROSTANOS DE LA FORMULA GENERAL I EN DONDE EL SIMBOLO DE LINEA CONTINUA CON LINEA INTERRUMPIDA SUPERPUESTA, EL SIMBOLO DE LINEA ONDULADA, R1, R2, R3 E Y TIENEN EL SIGNIFICADO INDICADO EN LA ESPECIFICACION ASI COMO SUS ESTEREOISOMEROS, ISOMEROS Z Y E, TAUTOMEROS, ISOMEROS OPTICOS Y MEZCLAS DE LOS MISMOS Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. TAMBIEN SE PRESENTAN LOS PROCESOS PARA SU PREPARACION, LAS COMPOSICIONES FARMACEUTICAS Y USOS PARA LA PRODUCCION DE UN MEDICAMENTO QUE LOS CONTENGA.
ES93110189T 1992-08-20 1993-06-25 Nuevos derivados de 17-hidroxiiminometil-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos. Expired - Lifetime ES2110030T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4227605A DE4227605C2 (de) 1992-08-20 1992-08-20 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten

Publications (1)

Publication Number Publication Date
ES2110030T3 true ES2110030T3 (es) 1998-02-01

Family

ID=6465986

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93110189T Expired - Lifetime ES2110030T3 (es) 1992-08-20 1993-06-25 Nuevos derivados de 17-hidroxiiminometil-5beta,14beta-androstano activos sobre el sistema cardiovascular, procesos para su preparacion y composiciones farmaceuticas que contienen los mismos.

Country Status (12)

Country Link
US (1) US5444055A (es)
EP (1) EP0583579B1 (es)
JP (1) JP3510651B2 (es)
KR (1) KR100276527B1 (es)
AT (1) ATE160784T1 (es)
CA (1) CA2103825C (es)
DE (2) DE4227605C2 (es)
DK (1) DK0583579T3 (es)
ES (1) ES2110030T3 (es)
GR (1) GR3026265T3 (es)
HK (1) HK1004919A1 (es)
ZA (1) ZA935866B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4227626C2 (de) * 1992-08-20 1994-11-17 Sigma Tau Ind Farmaceuti 17-Hydrazonomethyl-14ß-hydroxy-5ß-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DE4420501A1 (de) 1994-06-13 1995-12-14 Sigma Tau Ind Farmaceuti Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten
IT1279386B1 (it) * 1994-11-07 1997-12-10 Sigma Tau Ind Farmaceuti 1,5 derivati di 7a-metilperidroinden-3a-oli, attivi sul sistema cardiovascolare, procedimenti per la loro preparazione e composizioni
DE4442486A1 (de) * 1994-11-29 1996-05-30 Sigma Tau Ind Farmaceuti Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
IT1282286B1 (it) * 1995-05-11 1998-03-16 Sigma Tau Ind Farmaceuti Seco-d steroidi sul sistema cardiovascolare, processi per la loro preparazione e composizioni farmaceutiche che li contengono.
IT1282289B1 (it) * 1995-06-23 1998-03-16 Sigma Tau Ind Farmaceuti 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare,
DE19633376A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue Seco-D-Steroide, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten
DE19633349A1 (de) * 1996-08-19 1998-02-26 Sigma Tau Ind Farmaceuti Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3019242A (en) * 1960-07-01 1962-01-30 Upjohn Co 3, 20-dioximes of 11-hydroxyprogesterones

Also Published As

Publication number Publication date
EP0583579A2 (en) 1994-02-23
CA2103825A1 (en) 1994-02-21
DE4227605C2 (de) 1995-02-16
US5444055A (en) 1995-08-22
KR940005661A (ko) 1994-03-22
ATE160784T1 (de) 1997-12-15
JP3510651B2 (ja) 2004-03-29
EP0583579B1 (en) 1997-12-03
DE69315501D1 (de) 1998-01-15
KR100276527B1 (ko) 2001-02-01
DK0583579T3 (da) 1998-04-27
CA2103825C (en) 1999-01-12
GR3026265T3 (en) 1998-05-29
EP0583579A3 (en) 1995-03-22
JPH06184188A (ja) 1994-07-05
ZA935866B (en) 1994-03-09
DE4227605A1 (de) 1994-03-10
DE69315501T2 (de) 1998-04-16
HK1004919A1 (en) 1998-12-11

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