ES2107904T3 - Complejos metalicos de macromoleculas dendrimeras, agentes de diagnostico que los contienen asi como procedimiento para la preparacion de los complejos y agentes. - Google Patents

Complejos metalicos de macromoleculas dendrimeras, agentes de diagnostico que los contienen asi como procedimiento para la preparacion de los complejos y agentes.

Info

Publication number
ES2107904T3
ES2107904T3 ES95902117T ES95902117T ES2107904T3 ES 2107904 T3 ES2107904 T3 ES 2107904T3 ES 95902117 T ES95902117 T ES 95902117T ES 95902117 T ES95902117 T ES 95902117T ES 2107904 T3 ES2107904 T3 ES 2107904T3
Authority
ES
Spain
Prior art keywords
complexes
agents
contain
well
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902117T
Other languages
English (en)
Inventor
Heribert Schmitt-Willich
Johannes Platzek
Andreas Muhler
Thomas Frenzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2107904T3 publication Critical patent/ES2107904T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyamides (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

LA INVENCION TRATA DE NUEVOS COMPLEJOS METALICOS DE MACROMOLECULAS DENDRIMERICAS CONTENIENDO DE 8 A 64 IONES DE UN ELEMENTO DE NUMEROS D EORDEN 21-29, 39, 42-44, O 57-83, Y UN LIGANDO POLIMERICO QUE FORMA COMPLEJOS DE FORMULA (I) A(X){SUB,B}, EN DONDE A, X Y B TIENEN DIFERENTES SIGNIFICADOS, MEDIOS QUE CONTIENEN ESTOS COMPUESTOS ASI COMO LA UTILIZACION DE ESTOS EN EL DIAGNOSTICO. LA INVENCION TRATA ADEMAS DE UN PROCEDIMIENTO PARA LA OBTENCION DE LOS COMPLEJOS Y MEDIOS.
ES95902117T 1993-12-22 1994-12-02 Complejos metalicos de macromoleculas dendrimeras, agentes de diagnostico que los contienen asi como procedimiento para la preparacion de los complejos y agentes. Expired - Lifetime ES2107904T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4344460A DE4344460A1 (de) 1993-12-22 1993-12-22 Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel

Publications (1)

Publication Number Publication Date
ES2107904T3 true ES2107904T3 (es) 1997-12-01

Family

ID=6506205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902117T Expired - Lifetime ES2107904T3 (es) 1993-12-22 1994-12-02 Complejos metalicos de macromoleculas dendrimeras, agentes de diagnostico que los contienen asi como procedimiento para la preparacion de los complejos y agentes.

Country Status (20)

Country Link
US (1) US5759518A (es)
EP (1) EP0736059B1 (es)
JP (1) JP3683584B2 (es)
CN (1) CN1138341A (es)
AT (1) ATE156159T1 (es)
AU (1) AU690605B2 (es)
CA (1) CA2179624A1 (es)
CZ (1) CZ176096A3 (es)
DE (2) DE4344460A1 (es)
DK (1) DK0736059T3 (es)
ES (1) ES2107904T3 (es)
GR (1) GR3024933T3 (es)
HU (1) HUT75531A (es)
IL (1) IL111818A (es)
NO (1) NO962661D0 (es)
NZ (1) NZ276717A (es)
PL (1) PL315126A1 (es)
SK (1) SK80196A3 (es)
WO (1) WO1995017451A1 (es)
ZA (1) ZA9410281B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425857A1 (de) * 1994-07-07 1996-01-11 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19525924A1 (de) * 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US6166200A (en) * 1995-07-04 2000-12-26 Schering Aktiengesellschaft Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
AU726034B2 (en) * 1995-12-22 2000-10-26 Schering Aktiengesellschaft Cascade polymer complexes, process for their production and pharmaceutical agents that contain the latter
US5874061A (en) * 1995-12-22 1999-02-23 Schering Aktiengesellschaft Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
DE19549286A1 (de) * 1995-12-22 1997-06-26 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
WO1998006691A2 (en) 1996-08-14 1998-02-19 Warner-Lambert Company Low molecular weight dendritic compounds as pharmaceutical agents
DE19726340C2 (de) * 1996-08-16 1999-05-06 Schering Ag Zinndendrimere, ihre Verwendung als Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
JP4233117B2 (ja) * 1997-01-13 2009-03-04 住友化学株式会社 樹枝状ポリマーのナノコンポジット
US6224935B1 (en) 1999-01-28 2001-05-01 Cornell Research Foundation, Inc. Ordered arrays via metal-initiated self-assembly of ligand containing dendrimers and bridging ligands
PL353336A1 (en) * 1999-07-29 2003-11-17 Epix Medical, Inc. Targeting multimeric imaging agents through multilocus binding
FR2797563A1 (fr) * 1999-08-18 2001-02-23 Rhodianyl Composes biocides et leur utilisation dans des polymeres thermoplastiques
AU2002350991A1 (en) * 2001-06-25 2003-01-08 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Macromolecular imaging agents for liver imaging
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
AU2003279899A1 (en) * 2002-06-27 2004-01-19 Georgia Tech Research Corporation Nano-sized optical fluorescence labels and uses thereof
US6852842B2 (en) 2002-08-26 2005-02-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for functional kidney imaging using small dendrimer contrast agents
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
US7199268B2 (en) 2003-12-16 2007-04-03 Schering Aktiengesellschaft Process for the production of dendritic trimesic acid triamides
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
US20060204443A1 (en) * 2005-03-11 2006-09-14 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Methods for tumor treatment using dendrimer conjugates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5135737A (en) * 1986-11-10 1992-08-04 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for enhancement of diagnosis and therapy
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
DE69032374T2 (de) * 1989-10-23 1998-12-17 Nycomed Salutar, Inc., Sunnyvale, Calif. Mehrzähnige metall-chelatierende verbindungen
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5405601A (en) * 1993-07-02 1995-04-11 Mallinckrodt Medical Inc. Functionalized tripodal ligands for imaging applications
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
DE4344464A1 (de) * 1993-12-22 1995-06-29 Schering Ag Kaskadenpolymere mit Iodaromaten

Also Published As

Publication number Publication date
WO1995017451A1 (de) 1995-06-29
IL111818A (en) 2000-02-17
DE4344460A1 (de) 1995-06-29
CZ176096A3 (en) 1996-10-16
EP0736059B1 (de) 1997-07-30
JP3683584B2 (ja) 2005-08-17
AU1109395A (en) 1995-07-10
ATE156159T1 (de) 1997-08-15
HU9601742D0 (en) 1996-08-28
CA2179624A1 (en) 1995-06-29
NZ276717A (en) 1998-07-28
SK80196A3 (en) 1997-05-07
US5759518A (en) 1998-06-02
GR3024933T3 (en) 1998-01-30
JPH09506914A (ja) 1997-07-08
ZA9410281B (en) 1995-08-29
PL315126A1 (en) 1996-10-14
EP0736059A1 (de) 1996-10-09
DE59403584D1 (de) 1997-09-04
HUT75531A (en) 1997-05-28
AU690605B2 (en) 1998-04-30
IL111818A0 (en) 1995-01-24
NO962661L (no) 1996-06-21
NO962661D0 (no) 1996-06-21
CN1138341A (zh) 1996-12-18
DK0736059T3 (da) 1998-03-09

Similar Documents

Publication Publication Date Title
ES2107904T3 (es) Complejos metalicos de macromoleculas dendrimeras, agentes de diagnostico que los contienen asi como procedimiento para la preparacion de los complejos y agentes.
ATE159522T1 (de) Fluorhaltige makrocyclische metallkomplexe
DE60016898D1 (de) Phthalamid-lanthanid komplexe zur verwendung als lumineszenzmarker
ATE272049T1 (de) Salicylamid-lanthanid komplexe zur verwendung als lumineszenzmarker
IL90409A0 (en) Macrocyclic chelates
AU6996594A (en) Iodinated paramagnetic chelates, and their use as contrast agents
ATE174331T1 (de) Verwendung von makrocyclischen metallkomplexen als temperatursonden
DE602004016390D1 (en) Aromatische triamid-lanthanid-komplexe
BRPI0415891A (pt) processo para preparar um complexo de nìquel (0) e de ligando de fósforo, mistura, e, uso da mesma
KR960700219A (ko) 유도화된 DTPA 착화합물, 이 화합물을 함유하는 약제, NMR 및 방사선용 조영제로서의 이들의 용도 및 이들의 제조 방법(Derivatized DTPA Complexes, Pharmaceuticals Containing These Compunds, Their Use as NMR and Radiographic Contrasting Agents and Process for Producing the Same)
IL114858A0 (en) DTPA derivatives metal complexes thereof pharmaceutical and diagnostic agents containing the same and methods for the preparation thereof
ZA976117B (en) Pseudopolyrotaxanes.
ES2072912T3 (es) Nuevos ligandos ciclicos nitrogenados, complejos metalicos formados por estos ligandos, composiciones de diagnostico conteniendo estos complejos y procedimiento de preparacion de los ligandos.
Dasiewicz et al. Effect of sodium (I), calcium (II), lanthanum (III) and thorium (IV) on the aromatic system of p-hydroxybenzoates
DE69913368D1 (en) Chelatiermittel für radioimmunotherapie
GR3036205T3 (en) Use of phosphorus derivatives of alkaloids for treating endocrinopathies
Wu et al. Analyses of f→ f Transition Spectra of Ln (DPA) 3 3-ComplexeS

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 736059

Country of ref document: ES