DK0736059T3 - Metalkomplekser af dendrimerer, diagnostiske midler indeholdende samme og fremgangsmåde til fremstilling af komplekserne og de diagnostiske midler - Google Patents

Metalkomplekser af dendrimerer, diagnostiske midler indeholdende samme og fremgangsmåde til fremstilling af komplekserne og de diagnostiske midler

Info

Publication number
DK0736059T3
DK0736059T3 DK95902117.1T DK95902117T DK0736059T3 DK 0736059 T3 DK0736059 T3 DK 0736059T3 DK 95902117 T DK95902117 T DK 95902117T DK 0736059 T3 DK0736059 T3 DK 0736059T3
Authority
DK
Denmark
Prior art keywords
complexes
diagnostic agents
pct
dendrimers
preparation
Prior art date
Application number
DK95902117.1T
Other languages
English (en)
Inventor
Johannes Platzek
Heribert Schmitt-Willich
Andreas Muehler
Thomas Frenzel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0736059T3 publication Critical patent/DK0736059T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyamides (AREA)
DK95902117.1T 1993-12-22 1994-12-02 Metalkomplekser af dendrimerer, diagnostiske midler indeholdende samme og fremgangsmåde til fremstilling af komplekserne og de diagnostiske midler DK0736059T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4344460A DE4344460A1 (de) 1993-12-22 1993-12-22 Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel

Publications (1)

Publication Number Publication Date
DK0736059T3 true DK0736059T3 (da) 1998-03-09

Family

ID=6506205

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95902117.1T DK0736059T3 (da) 1993-12-22 1994-12-02 Metalkomplekser af dendrimerer, diagnostiske midler indeholdende samme og fremgangsmåde til fremstilling af komplekserne og de diagnostiske midler

Country Status (20)

Country Link
US (1) US5759518A (da)
EP (1) EP0736059B1 (da)
JP (1) JP3683584B2 (da)
CN (1) CN1138341A (da)
AT (1) ATE156159T1 (da)
AU (1) AU690605B2 (da)
CA (1) CA2179624A1 (da)
CZ (1) CZ176096A3 (da)
DE (2) DE4344460A1 (da)
DK (1) DK0736059T3 (da)
ES (1) ES2107904T3 (da)
GR (1) GR3024933T3 (da)
HU (1) HUT75531A (da)
IL (1) IL111818A (da)
NO (1) NO962661L (da)
NZ (1) NZ276717A (da)
PL (1) PL315126A1 (da)
SK (1) SK80196A3 (da)
WO (1) WO1995017451A1 (da)
ZA (1) ZA9410281B (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4425857A1 (de) * 1994-07-07 1996-01-11 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19525924A1 (de) 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US6166200A (en) * 1995-07-04 2000-12-26 Schering Aktiengesellschaft Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
AU726034B2 (en) * 1995-12-22 2000-10-26 Schering Aktiengesellschaft Cascade polymer complexes, process for their production and pharmaceutical agents that contain the latter
DE19549286A1 (de) * 1995-12-22 1997-06-26 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5874061A (en) * 1995-12-22 1999-02-23 Schering Aktiengesellschaft Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
WO1998006691A2 (en) 1996-08-14 1998-02-19 Warner-Lambert Company Low molecular weight dendritic compounds as pharmaceutical agents
DE19726340C2 (de) * 1996-08-16 1999-05-06 Schering Ag Zinndendrimere, ihre Verwendung als Röntgenkontrastmittel und Verfahren zu ihrer Herstellung
DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
JP4233117B2 (ja) * 1997-01-13 2009-03-04 住友化学株式会社 樹枝状ポリマーのナノコンポジット
US6224935B1 (en) 1999-01-28 2001-05-01 Cornell Research Foundation, Inc. Ordered arrays via metal-initiated self-assembly of ligand containing dendrimers and bridging ligands
AU6386000A (en) 1999-07-29 2001-02-19 Epix Pharmaceuticals, Inc. Targeting multimeric imaging agents through multilocus binding
FR2797563A1 (fr) * 1999-08-18 2001-02-23 Rhodianyl Composes biocides et leur utilisation dans des polymeres thermoplastiques
US20050019267A1 (en) * 2001-06-25 2005-01-27 Brechbiel Martin W Macromolecular imaging agents for liver imaging
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
ATE480775T1 (de) * 2002-06-27 2010-09-15 Georgia Tech Res Inst Optische fluoreszenzmarkierungen im nanomassstab und verwendungen davon
US6852842B2 (en) 2002-08-26 2005-02-08 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for functional kidney imaging using small dendrimer contrast agents
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
US7199268B2 (en) 2003-12-16 2007-04-03 Schering Aktiengesellschaft Process for the production of dendritic trimesic acid triamides
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
US20060204443A1 (en) * 2005-03-11 2006-09-14 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Methods for tumor treatment using dendrimer conjugates

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5135737A (en) * 1986-11-10 1992-08-04 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Amplifier molecules for enhancement of diagnosis and therapy
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
GB8923843D0 (en) * 1989-10-23 1989-12-13 Salutar Inc Compounds
US5446145A (en) * 1990-01-19 1995-08-29 Nycomed Salutar, Inc. Polychelant compounds
SG49726A1 (en) * 1989-10-23 1998-06-15 Nycomed Salutar Inc Compounds
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB9024208D0 (en) * 1990-11-07 1990-12-19 Salutar Inc Compounds
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5405601A (en) * 1993-07-02 1995-04-11 Mallinckrodt Medical Inc. Functionalized tripodal ligands for imaging applications
US5449761A (en) * 1993-09-28 1995-09-12 Cytogen Corporation Metal-binding targeted polypeptide constructs
DE4344464A1 (de) * 1993-12-22 1995-06-29 Schering Ag Kaskadenpolymere mit Iodaromaten

Also Published As

Publication number Publication date
HU9601742D0 (en) 1996-08-28
EP0736059B1 (de) 1997-07-30
CZ176096A3 (en) 1996-10-16
SK80196A3 (en) 1997-05-07
NO962661D0 (no) 1996-06-21
NZ276717A (en) 1998-07-28
GR3024933T3 (en) 1998-01-30
HUT75531A (en) 1997-05-28
NO962661L (no) 1996-06-21
ZA9410281B (en) 1995-08-29
JP3683584B2 (ja) 2005-08-17
AU1109395A (en) 1995-07-10
DE4344460A1 (de) 1995-06-29
ES2107904T3 (es) 1997-12-01
US5759518A (en) 1998-06-02
AU690605B2 (en) 1998-04-30
IL111818A (en) 2000-02-17
CN1138341A (zh) 1996-12-18
JPH09506914A (ja) 1997-07-08
IL111818A0 (en) 1995-01-24
ATE156159T1 (de) 1997-08-15
EP0736059A1 (de) 1996-10-09
CA2179624A1 (en) 1995-06-29
DE59403584D1 (de) 1997-09-04
WO1995017451A1 (de) 1995-06-29
PL315126A1 (en) 1996-10-14

Similar Documents

Publication Publication Date Title
DK0736059T3 (da) Metalkomplekser af dendrimerer, diagnostiske midler indeholdende samme og fremgangsmåde til fremstilling af komplekserne og de diagnostiske midler
ATE159522T1 (de) Fluorhaltige makrocyclische metallkomplexe
HU9600299D0 (en) Substituted azadioxacycloalkenes, fungicidal compositions containing them, process for the preparation of the compounds and the fungicidal compositions and method for combating fungi
IL90409A0 (en) Macrocyclic chelates
ATE219376T1 (de) Verfahren zur inhibierung der immunreaktion durch blockierung der gp39/cd40 und ctla4/cd28/b7 routen und zusammensetzung zu deren verwendung
PL320138A1 (en) Method of and solution for obtaining a conversive coating on metal surface
DE59407453D1 (de) Verwendung von makrocyclischen metallkomplexen als temperatursonden
EP1706452A4 (en) AROMATIC COMPLEXES OF TRIAMIDE-LANTHANIDE
DK0532566T3 (da) Cyklopentadienylcarbonyl-99mTc-komplekser, fremgangsmåde til fremstilling af disse samt deres anvendelse i diagnostikken
IL114858A0 (en) DTPA derivatives metal complexes thereof pharmaceutical and diagnostic agents containing the same and methods for the preparation thereof
IL117199A0 (en) Metal complexes of diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
ZA976117B (en) Pseudopolyrotaxanes.
IL108433A0 (en) Dtpa metal complex derivatives, pharmaceutical compositions containing the same, and methods for the preparation thereof
YU36104A (sh) Kristalna struktura fosfodiesteraza 5 i njihova upotreba
FR2637895B1 (fr) Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands
DK0680467T3 (da) Fremgangsmåde til fremstilling af C-substituerede diethylentriaminer
ATE200865T1 (de) Verwendung von phosphorderivaten von alkaloiden zur behandlung von endokrinopathien
MY102682A (en) Substituted pyridinesulfonamide compounds, herbicidal composition containing them, and method of preparing these compounds