ES2107422T3 - Moleculas de adn recombinante, huespedes, procedimientos y polipeptidos similares a proteinas portadoras de somatomedina humana. - Google Patents
Moleculas de adn recombinante, huespedes, procedimientos y polipeptidos similares a proteinas portadoras de somatomedina humana.Info
- Publication number
- ES2107422T3 ES2107422T3 ES90901407T ES90901407T ES2107422T3 ES 2107422 T3 ES2107422 T3 ES 2107422T3 ES 90901407 T ES90901407 T ES 90901407T ES 90901407 T ES90901407 T ES 90901407T ES 2107422 T3 ES2107422 T3 ES 2107422T3
- Authority
- ES
- Spain
- Prior art keywords
- dna molecules
- polypeptides
- carrier protein
- human
- hosts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nutrition Science (AREA)
- Ophthalmology & Optometry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
ESTA INVENCION SE REFIERE A POLIPEPTIDOS QUE SON SUBUNIDADES DE PROTEINA QUE TRANSPORTAN SOMATOMEDINA HUMANA, Y A PROCESOS PARA PRODUCIRLOS. LAS SUBMIDADES DE PROTEINA TRANSPORTADORA SE UNEN A POLIPEPTIDOS EN FORMA DE PROTEINA HUMANA, TAMBIEN CONOCIDOS COMO FACTORES DE CRECIMIENTO DE TIPO DE INSULINA. EL PROCESO INCLUYE LA PREPARACION A PARTIR DE UNA FRACCION DE SUERO HUMANO, COHN+V-1, POR UNA MOLECULA DE VARIOS PASOS CROMATOGRAFICOS. ESTA INVENCION TAMBIEN SE REFIERE A MOLECULAS DE ADN QUE CODIFICAN POLIPEPTIDOS EN FORMA DE PROTEINA TRANSPORTADORES DE SOMATOMEDINA HUMANA, MOLECULAS DE ADN RECOMBINANTES, RECEPTORES, PROCESOS PARA PRODUCIR POLIPEPTIDOS EN FORMA DE PROTEINA TRANSPORTADORA, POLIPEPTIDOS EN FORMA DE PROTEINA TRANSPORTADORES DE SOMATOMEDINA HUMANA PRODUCIDOS UTILIZANDO AQUELLAS MOLECULAS, RECEPTORES Y PROCESOS. LA INVENCION SE REFIERE A MOLECULAS DE ADN Y SU EXPRESION EN RECEPTORES APROPIADOS. LAS MOLECULAS DE ADN RECOMBINANTES CONTIENEN MOLECULAS DE ADN QUE CODIFICAN PARA POLIPEPTIDOS QUE TIENEN UNA ACTIVIDAD BIOLOGICA DE LA PROTEINA TRANSPORTADORA HUMANA O UNA SUBUNIDAD DE PROTEINA TRANSPORTADORA HUMANA CAPAZ DE LIGAR SOMATOMEDINAS. LAS MOLECULAS DE ADN, MOLECULAS DE ADN, RECOMBINANTES, RECEPTORES Y PROCESOS DE ESTA INVENCION PUDEN UTILIZARSE EN LA PRODUCCION DE POLIPEPTIDOS UTILES PARA VARIAS APLICACIONES TERAPEUTICAS, DIAGNOSTICOS Y OTRAS APLICACIONES UTILES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29025088A | 1988-12-22 | 1988-12-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2107422T3 true ES2107422T3 (es) | 1997-12-01 |
Family
ID=23115154
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90901407T Expired - Lifetime ES2107422T3 (es) | 1988-12-22 | 1989-12-21 | Moleculas de adn recombinante, huespedes, procedimientos y polipeptidos similares a proteinas portadoras de somatomedina humana. |
Country Status (14)
Country | Link |
---|---|
EP (2) | EP0375438A3 (es) |
JP (2) | JPH04503352A (es) |
KR (1) | KR910700261A (es) |
AT (1) | ATE155793T1 (es) |
AU (1) | AU4836890A (es) |
CA (1) | CA2006322C (es) |
DE (1) | DE68928203T2 (es) |
DK (1) | DK95291A (es) |
ES (1) | ES2107422T3 (es) |
GR (1) | GR3025094T3 (es) |
HK (1) | HK1000826A1 (es) |
IL (1) | IL92816A0 (es) |
WO (1) | WO1990006950A1 (es) |
ZA (1) | ZA899832B (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
US5198340A (en) * | 1991-01-17 | 1993-03-30 | Genentech, Inc. | Assay for free igf-i, igf-ii, and gh levels in body fluids |
US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
US5643867A (en) * | 1992-08-26 | 1997-07-01 | Celtrix Pharmaceuticals, Inc. | Method for treating catabolic conditions |
AU713275B2 (en) * | 1994-07-20 | 1999-11-25 | Celtrix Pharmaceuticals, Inc. | IGF/IGFBP complex for promoting bone formation and for regulating bone remodeling |
US5565204A (en) * | 1994-08-24 | 1996-10-15 | American Cyanamid Company | Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
PT1141014E (pt) | 1999-01-06 | 2005-04-29 | Genentech Inc | Variante mutante do factor de crescimento semelhante a insulina (igf-i) |
DK1141015T3 (da) | 1999-01-06 | 2010-01-25 | Genentech Inc | Insulin-lignende vækstfaktor (IGF) I-mutantvarianter |
EP1282437B1 (en) | 2000-05-16 | 2008-03-19 | Genentech, Inc. | Treatment of cartilage disorders |
AU2002248609B2 (en) | 2001-03-14 | 2007-03-01 | Genentech, Inc. | IGF antagonist peptides |
ES2527871T3 (es) | 2003-05-01 | 2015-02-02 | Imclone Llc | Anticuerpos completamente humanos dirigidos contra el receptor del factor de crecimiento 1 similar a la insulina humana |
CA2538342C (en) | 2003-09-12 | 2013-01-08 | Tercica, Inc. | Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency |
EP1670822A2 (en) | 2003-10-03 | 2006-06-21 | Genentech, Inc. | Igf binding proteins |
BRPI0611984A2 (pt) | 2005-06-17 | 2009-07-07 | Imclone Systems Inc | uso de anticorpos igf-ir para fabricação de um medicamento para tratar um tumor ósseo |
CA2641310C (en) | 2006-02-03 | 2013-08-20 | Imclone Systems Incorporated | Igf-ir antagonists as adjuvants for treatment of prostate cancer |
JP2020533344A (ja) | 2017-09-11 | 2020-11-19 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | 慢性肺疾患を治療するための方法および組成物 |
CA3194764A1 (en) | 2020-10-19 | 2022-04-28 | Oak Hill Bio Limited | Compositions suitable for use in neonates |
WO2023139115A1 (en) | 2022-01-19 | 2023-07-27 | Oak Hill Bio Limited | Compositions and methods for reducing oxidation of igf‐1/igfbp |
WO2023242442A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Method of maturing/differentiating neurons and/or modulating the vagus nerve |
WO2023242440A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Treament of lungs in infants |
WO2023242439A1 (en) | 2022-06-17 | 2023-12-21 | Oak Hill Bio Limited | Vascular stabilisation (preterm infants) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL68218A (en) * | 1983-03-23 | 1985-12-31 | Univ Ramot | Compositions for cartilage repair comprising embryonal chondrocytes |
US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
CA1322714C (en) * | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
US4885163A (en) * | 1987-02-24 | 1989-12-05 | Eli Lilly And Company | Topical use of IGF-II for wound healing |
IL89661A (en) * | 1988-03-17 | 1999-05-09 | Novo Nordisk As | Heparin binding proteins |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
JPH03504597A (ja) * | 1988-04-12 | 1991-10-09 | シナージェン,インコーポレーテッド | インスリン様成長因子活性の強化および阻害方法 |
-
1989
- 1989-12-20 IL IL92816A patent/IL92816A0/xx unknown
- 1989-12-21 ES ES90901407T patent/ES2107422T3/es not_active Expired - Lifetime
- 1989-12-21 JP JP2501912A patent/JPH04503352A/ja active Pending
- 1989-12-21 DE DE68928203T patent/DE68928203T2/de not_active Revoked
- 1989-12-21 AU AU48368/90A patent/AU4836890A/en not_active Abandoned
- 1989-12-21 EP EP19890313463 patent/EP0375438A3/en active Pending
- 1989-12-21 KR KR1019900701824A patent/KR910700261A/ko not_active Application Discontinuation
- 1989-12-21 AT AT90901407T patent/ATE155793T1/de not_active IP Right Cessation
- 1989-12-21 ZA ZA899832A patent/ZA899832B/xx unknown
- 1989-12-21 WO PCT/US1989/005791 patent/WO1990006950A1/en not_active Application Discontinuation
- 1989-12-21 CA CA002006322A patent/CA2006322C/en not_active Expired - Fee Related
- 1989-12-21 EP EP90901407A patent/EP0451194B1/en not_active Revoked
-
1991
- 1991-05-21 DK DK095291A patent/DK95291A/da unknown
-
1997
- 1997-10-20 GR GR970402735T patent/GR3025094T3/el unknown
- 1997-12-10 HK HK97102385A patent/HK1000826A1/xx not_active IP Right Cessation
-
1998
- 1998-10-23 JP JP10303047A patent/JPH11236400A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0451194B1 (en) | 1997-07-23 |
CA2006322C (en) | 2000-08-01 |
CA2006322A1 (en) | 1990-06-22 |
DE68928203T2 (de) | 1998-01-15 |
AU4836890A (en) | 1990-07-10 |
ATE155793T1 (de) | 1997-08-15 |
DK95291D0 (da) | 1991-05-21 |
JPH11236400A (ja) | 1999-08-31 |
IL92816A0 (en) | 1990-09-17 |
DK95291A (da) | 1991-08-16 |
JPH04503352A (ja) | 1992-06-18 |
ZA899832B (en) | 1990-10-31 |
GR3025094T3 (en) | 1998-01-30 |
EP0375438A2 (en) | 1990-06-27 |
EP0451194A1 (en) | 1991-10-16 |
EP0451194A4 (en) | 1992-09-02 |
DE68928203D1 (de) | 1997-09-04 |
HK1000826A1 (en) | 1998-05-01 |
WO1990006950A1 (en) | 1990-06-28 |
KR910700261A (ko) | 1991-03-14 |
EP0375438A3 (en) | 1992-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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