ES2105194T3 - Derivados de sales internas de fosfiniloxipropanaminio, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de sales internas de fosfiniloxipropanaminio, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2105194T3
ES2105194T3 ES93810406T ES93810406T ES2105194T3 ES 2105194 T3 ES2105194 T3 ES 2105194T3 ES 93810406 T ES93810406 T ES 93810406T ES 93810406 T ES93810406 T ES 93810406T ES 2105194 T3 ES2105194 T3 ES 2105194T3
Authority
ES
Spain
Prior art keywords
fosfiniloxipropanaminio
derivatives
procedure
contain
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93810406T
Other languages
English (en)
Inventor
Robert Charles Anderson
Gregory R Bebernitz
James D Fraser
Jeffrey W Hughes
Prasad K Kapa
Mahavir Prashad
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Novartis AG filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2105194T3 publication Critical patent/ES2105194T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C07F9/1651—Esters of thiophosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA INVENCION CONCIERNE A LOS COMPUESTOS DE LA FORMULA (I) DONDE LOS SUSTITUYENTES TIENEN VARIOS SIGNIFICADOS, EN FORMA DE ACIDO LIBRE, ESTER FISIOLOGICAMENTE HIDROSOLUBLE O FORMA DE PRODROGA. PUEDEN PREPARARSE POR VARIOS PROCEDIMIENTOS, P.EJ. ENLAZANDO ACOMPAÑADOS POR OXIDACION O TIOLACION E HIDROLISIS O TIOLISIS, O POR REDUCCION A AMINO DE UN NITRO SUSTITUYENTE SOBRE UN ANILLO AROMATICO. POSEEN ACTIVIDAD HIPOGLUCEMICA Y POR ELLO ESTAN INDICADOS PARA USO EN EL TRATAMIENTO DE DIABETES.
ES93810406T 1992-06-11 1993-06-07 Derivados de sales internas de fosfiniloxipropanaminio, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2105194T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89721092A 1992-06-11 1992-06-11

Publications (1)

Publication Number Publication Date
ES2105194T3 true ES2105194T3 (es) 1997-10-16

Family

ID=25407534

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93810406T Expired - Lifetime ES2105194T3 (es) 1992-06-11 1993-06-07 Derivados de sales internas de fosfiniloxipropanaminio, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (21)

Country Link
EP (1) EP0574355B1 (es)
JP (1) JPH0673077A (es)
KR (1) KR940005647A (es)
CN (1) CN1039326C (es)
AT (1) ATE156828T1 (es)
AU (1) AU667537B2 (es)
CA (1) CA2098133A1 (es)
CZ (1) CZ108393A3 (es)
DE (1) DE69313029T2 (es)
DK (1) DK0574355T3 (es)
ES (1) ES2105194T3 (es)
FI (1) FI932662A (es)
GR (1) GR3024684T3 (es)
HU (2) HUT65327A (es)
IL (1) IL105965A (es)
MY (1) MY109005A (es)
NO (1) NO932096L (es)
NZ (1) NZ247840A (es)
SG (1) SG42983A1 (es)
SK (1) SK58893A3 (es)
ZA (1) ZA934157B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1299266B1 (it) 1998-05-15 2000-02-29 Sigma Tau Ind Farmaceuti Inibitori reversibili della carnitina palmitoil trasferasi
WO2004074298A1 (ja) * 2003-02-18 2004-09-02 Tokai University ホスホリルコリン基を有する化合物、その重合体ならびにその製造方法
CA2658797A1 (en) 2006-08-02 2008-02-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Derivatives of 4-trimethylammonium-3-aminobutyrate and 4-trimethylphosphonium-3-aminobutyrate as cpt-inhibitors
CA3152868A1 (en) 2019-08-30 2021-03-04 Institute Of Zoology, Chinese Academy Of Sciences Composition used for combating metabolic diseases and uses of composition

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0348859A1 (en) * 1988-07-01 1990-01-03 MAGIS FARMACEUTICI S.p.A. 1,2-di-O-acyl glycero(DI)phosphate of L-carnitine and its derivatives, a process for their preparation and pharmaceutical formulations which contain them
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
IT1230141B (it) * 1989-05-03 1991-10-14 Fidia Spa Impiego di derivati della fosfatidil carnitina per la preparazione di composizioni farmaceutiche aventi attivita' nella terapia delle patologie dell'uomo associate con un danno neuronale.
IT1230142B (it) * 1989-05-03 1991-10-14 Fidia Spa Derivati della carnitina, processo per la loro preparazione e impiego in terapia umana

Also Published As

Publication number Publication date
SG42983A1 (en) 1997-10-17
HUT65327A (en) 1994-05-02
NO932096D0 (no) 1993-06-09
ATE156828T1 (de) 1997-08-15
IL105965A (en) 1997-03-18
AU4011593A (en) 1993-12-16
GR3024684T3 (en) 1997-12-31
DE69313029T2 (de) 1998-01-29
EP0574355B1 (en) 1997-08-13
HU211489A9 (en) 1995-11-28
HU9301587D0 (en) 1993-09-28
CZ108393A3 (en) 1995-02-15
FI932662A0 (fi) 1993-06-10
NZ247840A (en) 1995-04-27
KR940005647A (ko) 1994-03-22
CA2098133A1 (en) 1993-12-12
CN1086217A (zh) 1994-05-04
FI932662A (fi) 1993-12-12
DK0574355T3 (da) 1998-01-26
DE69313029D1 (de) 1997-09-18
ZA934157B (en) 1994-09-05
NO932096L (no) 1993-12-13
AU667537B2 (en) 1996-03-28
JPH0673077A (ja) 1994-03-15
IL105965A0 (en) 1993-10-20
SK58893A3 (en) 1994-06-08
EP0574355A1 (en) 1993-12-15
MY109005A (en) 1996-11-30
CN1039326C (zh) 1998-07-29

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