ES2103376T3 - Perfeccionamientos introducidos en los agentes de contraste. - Google Patents

Perfeccionamientos introducidos en los agentes de contraste.

Info

Publication number
ES2103376T3
ES2103376T3 ES92915200T ES92915200T ES2103376T3 ES 2103376 T3 ES2103376 T3 ES 2103376T3 ES 92915200 T ES92915200 T ES 92915200T ES 92915200 T ES92915200 T ES 92915200T ES 2103376 T3 ES2103376 T3 ES 2103376T3
Authority
ES
Spain
Prior art keywords
contrast agents
improvements introduced
microparticle
liquid carrier
carrier medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92915200T
Other languages
English (en)
Inventor
Arne Berg
Jo Klaveness
Per Strande
Lars Stubberud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare AS
Original Assignee
Nycomed Imaging AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26299192&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2103376(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919114565A external-priority patent/GB9114565D0/en
Priority claimed from GB929200386A external-priority patent/GB9200386D0/en
Application filed by Nycomed Imaging AS filed Critical Nycomed Imaging AS
Application granted granted Critical
Publication of ES2103376T3 publication Critical patent/ES2103376T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Acoustics & Sound (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

AGENTES DE CONTRASTE DE ULTRASONIDO QUE COMPRENDEN UNA SUSPENSION GENERADORA DE MICROBURBUJAS DE UN AGENTE DE CONTRASTE DE RAYOS X DE MICROPARTICULAS EN UN MEDIO PORTADOR LIQUIDO.
ES92915200T 1991-07-05 1992-07-03 Perfeccionamientos introducidos en los agentes de contraste. Expired - Lifetime ES2103376T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919114565A GB9114565D0 (en) 1991-07-05 1991-07-05 Improvements in or relating to contrast agents
GB929200386A GB9200386D0 (en) 1992-01-09 1992-01-09 Improvements in or relating to contrast agents

Publications (1)

Publication Number Publication Date
ES2103376T3 true ES2103376T3 (es) 1997-09-16

Family

ID=26299192

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92915200T Expired - Lifetime ES2103376T3 (es) 1991-07-05 1992-07-03 Perfeccionamientos introducidos en los agentes de contraste.

Country Status (15)

Country Link
US (2) US5607661A (es)
EP (1) EP0593624B1 (es)
JP (1) JPH06510758A (es)
AT (1) ATE151993T1 (es)
AU (1) AU675050B2 (es)
CA (1) CA2112109A1 (es)
DE (1) DE69219337T2 (es)
DK (1) DK0593624T3 (es)
ES (1) ES2103376T3 (es)
FI (1) FI940027A0 (es)
GR (1) GR3023394T3 (es)
HK (1) HK1006945A1 (es)
IE (1) IE80926B1 (es)
NO (1) NO940015D0 (es)
WO (1) WO1993000930A1 (es)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9106686D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
DK0605477T4 (da) * 1991-09-17 2007-10-01 Ge Healthcare As Gasformige ultralydskontrastmidler
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
NZ262237A (en) * 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5798091A (en) 1993-07-30 1998-08-25 Alliance Pharmaceutical Corp. Stabilized gas emulsion containing phospholipid for ultrasound contrast enhancement
JP3559849B2 (ja) 1993-07-30 2004-09-02 アイエムシーオーアール ファーマシューティカル カンパニー 超音波技術のための安定化された微小気泡組成物
US5540909A (en) * 1994-09-28 1996-07-30 Alliance Pharmaceutical Corp. Harmonic ultrasound imaging with microbubbles
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
US5897851A (en) * 1995-06-07 1999-04-27 Sonus Pharmaceuticals, Inc. Nucleation and activation of a liquid-in-liquid emulsion for use in ultrasound imaging
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
JP3178724B2 (ja) * 1996-03-05 2001-06-25 エイカスフィアー・インコーポレーテッド 画像化剤として使用するためのミクロカプセル化フッ素化ガス
GB9622711D0 (en) * 1996-10-31 1997-01-08 British Tech Group Instrument having enhanced ultrasound visibility
US6054118A (en) * 1997-01-22 2000-04-25 Nycomed Imaging As Contrast agents comprising two types of gas-containing microparticles
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
AU2683899A (en) * 1998-02-19 1999-09-06 University Of Virginia Patent Foundation The use of bjerknes forces to manipulate contrast agents
WO2001091805A2 (en) 2000-06-02 2001-12-06 Bracco Research Usa Compounds for targeting endothelial cells
ATE376803T1 (de) * 2001-04-06 2007-11-15 Bracco Research Sa Vorrichtung zur messung lokaler physikalischer parameter in einem flüssigkeitsgefüllten hohlraum
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
EP2014310B8 (en) 2002-03-01 2012-12-26 Dyax Corp. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) * 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) * 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2004078778A2 (en) 2003-03-03 2004-09-16 Dyax Corp. PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF
SE526838C2 (sv) * 2003-11-27 2005-11-08 Xcounter Ab Undersökningsmetod och anordning för detektion av joniserande strålning
US20050255175A1 (en) * 2004-05-17 2005-11-17 Burgess W P Method for protecting nephron against injury caused by disruption of a chemical environment in the kidneys
US7019035B2 (en) * 2004-05-17 2006-03-28 Md Scientific Llc Method for attenuating free radical formation resulting from bodily insult
US20050255176A1 (en) * 2004-05-17 2005-11-17 Burgess W P Method for attenuating free radical formation resulting from bodily insult
US7625586B2 (en) * 2004-10-28 2009-12-01 Md Scientific, Llc Method for mitigating injury to a kidney resulting from an ischemic event
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US9827265B1 (en) 2012-04-06 2017-11-28 Md Scientific, Llc Method for attenuating free radical formation resulting from a bodily insult
WO2016033380A1 (en) 2014-08-28 2016-03-03 The General Hospital Corporation Compositions and methods for treatment of neurological disorders
US11504322B2 (en) 2014-08-28 2022-11-22 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
US11471401B2 (en) 2014-08-28 2022-10-18 The General Hospital Corporation Injectable slurries and methods of manufacturing the same
CN114576893A (zh) 2016-02-26 2022-06-03 通用医疗公司 医用冰浆生产和递送系统和方法
JP7211699B2 (ja) * 2017-09-11 2023-01-24 バイエル ファーマ アクチエンゲゼルシャフト 超音波診断用造影剤
US11241330B1 (en) 2021-04-02 2022-02-08 Brixton Biosciences, Inc. Apparatus for creation of injectable slurry

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2680133A (en) * 1951-08-24 1954-06-01 Mallinckrodt Chemical Works Iodine-containing amino-benzoyl derivatives of amino acids
DE2629228C2 (de) * 1976-06-25 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Jodierte Isophthalamsäure-Derivate Verfahren zu deren Herstellung sowie deren Verwendung
US4192859A (en) * 1978-09-29 1980-03-11 E. R. Squibb & Sons, Inc. Contrast media containing liposomes as carriers
WO1982001642A1 (en) * 1980-11-17 1982-05-27 Med Inc Ultra Microbubble precursors and methods for their production and use
US4572203A (en) * 1983-01-27 1986-02-25 Feinstein Steven B Contact agents for ultrasonic imaging
DE3834705A1 (de) * 1988-10-07 1990-04-12 Schering Ag Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
US4744989A (en) * 1984-02-08 1988-05-17 E. R. Squibb & Sons, Inc. Method of preparing liposomes and products produced thereby
US5354549A (en) * 1987-07-24 1994-10-11 Nycomed Imaging As Iodinated esters
DE3828905A1 (de) * 1988-08-23 1990-03-15 Schering Ag Mittel bestehend aus cavitate oder clathrate bildenden wirt/gast-komplexen als kontrastmittel
GB8900376D0 (en) * 1989-01-09 1989-03-08 Nycomed As Iodinated esters
US5215680A (en) * 1990-07-10 1993-06-01 Cavitation-Control Technology, Inc. Method for the production of medical-grade lipid-coated microbubbles, paramagnetic labeling of such microbubbles and therapeutic uses of microbubbles
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5233995A (en) * 1991-11-21 1993-08-10 Sterling Winthrop Inc. Encapsulated particles useful as contrast agents in ultrasound and x-ray imaging compositions and methods

Also Published As

Publication number Publication date
DE69219337T2 (de) 1997-10-09
EP0593624B1 (en) 1997-04-23
AU2277292A (en) 1993-02-11
NO940015L (no) 1994-01-04
ATE151993T1 (de) 1997-05-15
DE69219337D1 (de) 1997-05-28
AU675050B2 (en) 1997-01-23
US5772984A (en) 1998-06-30
DK0593624T3 (da) 1997-05-20
HK1006945A1 (en) 1999-03-26
EP0593624A1 (en) 1994-04-27
GR3023394T3 (en) 1997-08-29
WO1993000930A1 (en) 1993-01-21
CA2112109A1 (en) 1993-01-21
IE922179A1 (en) 1993-01-13
FI940027A (fi) 1994-01-04
JPH06510758A (ja) 1994-12-01
US5607661A (en) 1997-03-04
NO940015D0 (no) 1994-01-04
IE80926B1 (en) 1999-06-30
FI940027A0 (fi) 1994-01-04

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