ES2148512T3 - Complejos de inclusion multicomponentes de alta solubilidad que constan de una sustancia farmaceutica acidica, una ciclodextrina y una base. - Google Patents

Complejos de inclusion multicomponentes de alta solubilidad que constan de una sustancia farmaceutica acidica, una ciclodextrina y una base.

Info

Publication number
ES2148512T3
ES2148512T3 ES95916656T ES95916656T ES2148512T3 ES 2148512 T3 ES2148512 T3 ES 2148512T3 ES 95916656 T ES95916656 T ES 95916656T ES 95916656 T ES95916656 T ES 95916656T ES 2148512 T3 ES2148512 T3 ES 2148512T3
Authority
ES
Spain
Prior art keywords
cyclodextrin
base
inclusion complexes
high solubility
pharmaceutical substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95916656T
Other languages
English (en)
Inventor
Paolo Chiesi
Paolo Ventura
Canale Maurizio Del
Maurizio Redenti
Daniela Acerbi
Massimo Pasini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Application granted granted Critical
Publication of ES2148512T3 publication Critical patent/ES2148512T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Public Health (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

SE MUESTRAN COMPLEJOS DE INCLUSION MULTICOMPONENTES CARACTERIZADOS POR LA PRESENCIA DE UN MEDICAMENTO ACIDICO, UNA BASE Y UNA CICLODEXTRINA. ESTOS COMPLEJOS TIENE UNA SOLUBILIDAD ESPECIFICA EN EL AGUA.
ES95916656T 1994-04-22 1995-04-13 Complejos de inclusion multicomponentes de alta solubilidad que constan de una sustancia farmaceutica acidica, una ciclodextrina y una base. Expired - Lifetime ES2148512T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI940790A IT1269578B (it) 1994-04-22 1994-04-22 Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo acido, una ciclodestrina e una base.

Publications (1)

Publication Number Publication Date
ES2148512T3 true ES2148512T3 (es) 2000-10-16

Family

ID=11368715

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95916656T Expired - Lifetime ES2148512T3 (es) 1994-04-22 1995-04-13 Complejos de inclusion multicomponentes de alta solubilidad que constan de una sustancia farmaceutica acidica, una ciclodextrina y una base.

Country Status (13)

Country Link
US (1) US5773029A (es)
EP (1) EP0756493B1 (es)
AT (1) ATE194777T1 (es)
AU (1) AU2307695A (es)
CA (1) CA2188388A1 (es)
DE (1) DE69518070T2 (es)
ES (1) ES2148512T3 (es)
HK (1) HK1013627A1 (es)
IL (1) IL113450A (es)
IT (1) IT1269578B (es)
PT (1) PT756493E (es)
WO (1) WO1995028965A1 (es)
ZA (1) ZA953206B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018245A1 (en) * 1995-11-14 1997-05-22 Farmarc Nederland B.V. Complex of naproxen and beta-cyclodextrin
UA57734C2 (uk) 1996-05-07 2003-07-15 Пфайзер Інк. Комплекси включення арилгетероциклічних солей
DK0811386T3 (da) * 1996-05-07 2005-01-03 Pfizer Fremgangsmåde til udvælgelse af et salt til fremstilling af et inklusionskompleks
US6383471B1 (en) 1999-04-06 2002-05-07 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
US6939863B2 (en) 2002-01-04 2005-09-06 Wei-Jan Chen Prevention of atherosclerosis and restenosis
MXPA04009968A (es) 2002-04-09 2004-12-13 Flamel Tech Sa Formulacion farmaceutica oral bajo forma de suspension acuosa de microcapsulas que permiten la liberacion modificada de principio (s) activo (s).
ES2286177T3 (es) * 2002-06-17 2007-12-01 Chiesi Farmaceutici S.P.A. Procedimiento para la preparacion de piroxicam: compuestos de inclusion de betaciclodextrina.
WO2004017897A2 (en) * 2002-08-20 2004-03-04 Bristol-Myers Squibb Company Aripiprazole complex formulation and method
US7993654B2 (en) 2002-12-23 2011-08-09 Beiersdorf Ag Self-adhesive polymer matrix containing sea algae extract
DE10260872B4 (de) 2002-12-23 2013-09-26 Beiersdorf Ag Verwendung von gelbildendem Polymer, Wasser, Alkohol und Meeresalgenextrakt zur Einstellung von Elastizität und Haftvermögen selbstklebender kosmetischer Polymermatrices
DE10260873A1 (de) 2002-12-23 2004-07-15 Beiersdorf Ag Selbstklebende Polymermatrix mit einem Gehalt an Meeresalgenextrakt und Glycerin
US20070020578A1 (en) * 2005-07-19 2007-01-25 Scott Robert R Dental curing light having a short wavelength LED and a fluorescing lens for converting wavelength light to curing wavelengths and related method
WO2006034147A2 (en) * 2004-09-16 2006-03-30 Abraxis Bioscience, Inc. Compositions and methods for the preparation and administration of poorly water soluble drugs
EP1954256A2 (en) * 2005-11-09 2008-08-13 Torrent Pharmaceuticals Ltd Pharmaceutical composition comprising a compound having a catechol moiety and an alkalising agent
FR2914187B1 (fr) * 2007-03-28 2011-01-21 Pf Medicament Complexes d'ibuprofene, de cyclodextrines et d'agents ternaires, et leurs utilisations en pharmaceutique.
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
CA2763365C (en) 2009-05-29 2016-09-13 Cydex Pharmaceuticals, Inc. Injectable melphalan compositions comprising a cyclodextrin derivative and methods of making and using the same
CN108210501B (zh) 2016-12-14 2019-03-08 中国人民解放军军事医学科学院毒物药物研究所 一种磺酰脲类药物的注射用药物组合物及其制备方法
CN117320727A (zh) * 2021-03-04 2023-12-29 生物切萨皮克有限责任公司 低吸附格列本脲制剂及方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1196033B (it) * 1984-02-22 1988-11-10 Chiesi Farma Spa Composto ad attivita' antiinfiammatoria ottenuto per complessazione con beta-ciclodestrina e relative formulazioni farmaceutiche
GR880100854A (el) * 1987-12-22 1994-03-31 Glaxo Group Ltd Υδατικές διαμορφώσεις που περιέχουν ενα παράγωγο πιπεριδινυλκυκλοπεντυλεπτενοικού οξέος.
IT1263831B (it) * 1993-01-29 1996-09-04 Paolo Chiesi Complessi di inclusione multicomponente ad elevata solubilita' costituiti da un farmaco di tipo basico, un acido ed una ciclodestrina

Also Published As

Publication number Publication date
DE69518070D1 (de) 2000-08-24
WO1995028965A1 (en) 1995-11-02
PT756493E (pt) 2000-10-31
AU2307695A (en) 1995-11-16
US5773029A (en) 1998-06-30
DE69518070T2 (de) 2001-01-11
ITMI940790A1 (it) 1995-10-22
IL113450A (en) 1999-05-09
ZA953206B (en) 1996-01-03
CA2188388A1 (en) 1995-11-02
EP0756493B1 (en) 2000-07-19
EP0756493A1 (en) 1997-02-05
IL113450A0 (en) 1995-07-31
ATE194777T1 (de) 2000-08-15
ITMI940790A0 (it) 1994-04-22
HK1013627A1 (en) 1999-09-03
IT1269578B (it) 1997-04-08

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