ES2102191T3 - Utilizacion de benzotriazinas como agentes inhibidores de la pla2 y nuevas benzotriazinas. - Google Patents
Utilizacion de benzotriazinas como agentes inhibidores de la pla2 y nuevas benzotriazinas.Info
- Publication number
- ES2102191T3 ES2102191T3 ES94902771T ES94902771T ES2102191T3 ES 2102191 T3 ES2102191 T3 ES 2102191T3 ES 94902771 T ES94902771 T ES 94902771T ES 94902771 T ES94902771 T ES 94902771T ES 2102191 T3 ES2102191 T3 ES 2102191T3
- Authority
- ES
- Spain
- Prior art keywords
- alkoxy
- benzotriazines
- alkyl
- pct
- new
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
LA INVENCION SE REFIERE A LA UTILIZACION DE COMPUESTOS DE LA FORMULA (I) EN DONDE R{SUB.1} ES UN GRUPO AMINO, UN GRUPO C{SUB.1} - C{SUB.6} - ALQUILAMINO, GRUPO DI - C{SUB.1} -C{SUB.6} - ALQUILAMINO O GRUPO HIDROXI, R{SUB.2} Y R{SUB.3}, QUE SON IGUALES O DIFERENTES, SIGNIFICAN RESPECTIVAMENTE HIDROGENO, HALOGENO, C{SUB.1} - C{SUB.6} - ALQUIL, C{SUB.1} - C{SUB.6} ALCOXI, CIANO, CARBOXI, HALOGENO - C{SUB.1} - C{SUB.6} - ALQUIL, CIANO - C{SUB.1} - C{SUB.6} - ALQUIL, CARBOXI - C{SUB.1} C{SUB.6} - ALQUIL, HIDROXI, CARBOXI - C{SUB.1} - C{SUB.6} ALCOXI, C{SUB.1} - C{SUB.6} - ALCOXICARBONIL - C{SUB.1} C{SUB.6} - ALCOXI O AMINOCARBONIL - C{SUB.1} - C{SUB.6} -ALCOXI, C{SUB.1} - C{SUB.6} - ALQUILAMINOCARBONIL - C{SUB.1} - C{SUB.6} ALCOXI O DI C{SUB.1} - C{SUB.6} - ALQUILAMINOCARBONIL C{SUB.1} - C{SUB.6} - ALCOXI Y N SIGNIFICA LA CIFRA 0 O 1, SUS TAUTOMEROS ASI COMO LAS SALES CON ACIDOS NO TOXICOS O BASES, PARA LA ELABORACION DE MEDICAMENTOS CON EFECTO INHIBIDOR PLA2, NUEVOS COMPUESTOS Y PROCESO PARA SUELABORACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4244009A DE4244009A1 (de) | 1992-12-24 | 1992-12-24 | Verwendung von Benzotriazinen als PLA¶2¶-Inhibitoren, neue Benzotriazine, Verfahren zu ihrer Herstellung und Arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2102191T3 true ES2102191T3 (es) | 1997-07-16 |
Family
ID=6476492
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94902771T Expired - Lifetime ES2102191T3 (es) | 1992-12-24 | 1993-12-15 | Utilizacion de benzotriazinas como agentes inhibidores de la pla2 y nuevas benzotriazinas. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5856325A (es) |
EP (1) | EP0675881B1 (es) |
JP (1) | JPH08504783A (es) |
AT (1) | ATE150457T1 (es) |
AU (1) | AU5699894A (es) |
CA (1) | CA2152614A1 (es) |
DE (2) | DE4244009A1 (es) |
ES (1) | ES2102191T3 (es) |
WO (1) | WO1994014781A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20040001144A (ko) * | 2002-06-27 | 2004-01-07 | 김대경 | 신규한 적혈구 세포질형 포스포리파아제 에이 투 효소,그에 대한 항체, 이들의 용도 및 제조 방법 |
CN104105692B (zh) * | 2011-12-07 | 2016-06-29 | 思研(Sri)国际顾问与咨询公司 | 作为结核分枝杆菌靶向药物的苯并三嗪氧化物 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2489351A (en) * | 1946-04-10 | 1949-11-29 | Merck & Co Inc | Preparation of benzotriazine compounds |
US2489352A (en) * | 1946-04-10 | 1949-11-29 | Merck & Co Inc | Halogen compounds of 3 aminobenzotriazine 1, 2, 4 oxide-1 |
US2489359A (en) * | 1947-01-10 | 1949-11-29 | Merck & Co Inc | Benzotriazines |
US2489353A (en) * | 1947-01-10 | 1949-11-29 | Merck & Co Inc | Benzotriazines |
US2489357A (en) * | 1947-01-10 | 1949-11-29 | Merck & Co Inc | Benzotriazines |
US2911406A (en) * | 1958-06-30 | 1959-11-03 | Searle & Co | 3-hydrazino-1, 2, 4-benzotriazines and 1-oxides thereof |
US2966487A (en) * | 1958-07-01 | 1960-12-27 | Searle & Co | 3-aminoalkylaminobenzotriazine-1-oxides |
US3079390A (en) * | 1958-12-12 | 1963-02-26 | Searle & Co | N-substituted 3-amino-1, 2, 4-benzotriazine-1-oxides |
CH514610A (de) * | 1967-09-27 | 1971-10-31 | Siegfried Ag | Verfahren zur Herstellung von fluorsubstituierten 1,2,4-Benztriazin-Derivaten |
US3681334A (en) * | 1970-02-18 | 1972-08-01 | Bayer Ag | Phosphoric (-phosphonic) and thiono-phosphoric (-phosphonic) acid esters |
DE2538179C2 (de) * | 1975-08-27 | 1986-05-28 | Bayer Ag, 5090 Leverkusen | 3-Alkoxy-benzo-1,2,4-triazine, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Fungizide |
US5175287A (en) * | 1986-09-25 | 1992-12-29 | S R I International | Process for preparing 1,2,4-benzotriazine oxides |
-
1992
- 1992-12-24 DE DE4244009A patent/DE4244009A1/de not_active Withdrawn
-
1993
- 1993-12-15 AU AU56998/94A patent/AU5699894A/en not_active Abandoned
- 1993-12-15 DE DE59305911T patent/DE59305911D1/de not_active Expired - Fee Related
- 1993-12-15 EP EP94902771A patent/EP0675881B1/de not_active Expired - Lifetime
- 1993-12-15 JP JP6514765A patent/JPH08504783A/ja active Pending
- 1993-12-15 US US08/464,631 patent/US5856325A/en not_active Expired - Fee Related
- 1993-12-15 AT AT94902771T patent/ATE150457T1/de not_active IP Right Cessation
- 1993-12-15 CA CA002152614A patent/CA2152614A1/en not_active Abandoned
- 1993-12-15 WO PCT/EP1993/003542 patent/WO1994014781A1/de active IP Right Grant
- 1993-12-15 ES ES94902771T patent/ES2102191T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0675881B1 (de) | 1997-03-19 |
WO1994014781A1 (de) | 1994-07-07 |
JPH08504783A (ja) | 1996-05-21 |
US5856325A (en) | 1999-01-05 |
AU5699894A (en) | 1994-07-19 |
DE4244009A1 (de) | 1994-06-30 |
DE59305911D1 (de) | 1997-04-24 |
CA2152614A1 (en) | 1994-07-07 |
EP0675881A1 (de) | 1995-10-11 |
ATE150457T1 (de) | 1997-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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