ES2101863T3 - Procedimiento para la produccion de capsulas biocompatibles que contienen celulas. - Google Patents

Procedimiento para la produccion de capsulas biocompatibles que contienen celulas.

Info

Publication number
ES2101863T3
ES2101863T3 ES92917748T ES92917748T ES2101863T3 ES 2101863 T3 ES2101863 T3 ES 2101863T3 ES 92917748 T ES92917748 T ES 92917748T ES 92917748 T ES92917748 T ES 92917748T ES 2101863 T3 ES2101863 T3 ES 2101863T3
Authority
ES
Spain
Prior art keywords
cells
capsules containing
procedure
production
containing cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92917748T
Other languages
English (en)
Inventor
Heather Anne Clayton
Roger Frank Lever James
Nicholas John Milton London
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Leicester
Original Assignee
University of Leicester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919117980A external-priority patent/GB9117980D0/en
Priority claimed from GB929207143A external-priority patent/GB9207143D0/en
Application filed by University of Leicester filed Critical University of Leicester
Application granted granted Critical
Publication of ES2101863T3 publication Critical patent/ES2101863T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

AQUI SE EXPONE UN METODO DE HACER CAPSULAS BIOCOMPATIBLES QUE CONTIENEN CELULAS COMPRENDIENDO LOS PASOS DE SUSPENDER CELULAS EN UN MEDIO ACUOSO QUE CONTIENE GOMA SOLUBLE EN AGUA PRE-DIALIZADA LA CUAL TIENE MITADES ANIONICAS PLURALES PERO ESTA SUSTANCIALMENTE EXENTA DE PROTEINA, FORMAR LA SUSPENSION EN GOTITAS QUE CONTIENEN LAS CELULAS, SOMETER LAS GOTITAS A UNA SOLUCION DE CATIONES COMPATIBLES FISIOLOGICAMENTE MULTIVALENTES PARA GELIFICAR LAS GOTITAS, ENCAPSULAR DICHAS CELULAS, SOMETER LAS CITADAS GOTITAS GELIFICADAS A UN POLIMERO QUE CONTIENE GRUPOS CATIONICOS LOS CUALES SE DEGRADAN CON DICHOS GRUPOS ANIONICOS PARA FORMAR UNA MEMBRANA SEMI-PERMEABLE Y CUBRIR DICHA MEMBRANA SEMI-PERMEABLE CON UNA CAPA DE DICHA GOMA SOLUBLE EN AGUA PRE-DIALIZADA.
ES92917748T 1991-08-20 1992-08-14 Procedimiento para la produccion de capsulas biocompatibles que contienen celulas. Expired - Lifetime ES2101863T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919117980A GB9117980D0 (en) 1991-08-20 1991-08-20 A method of making biocompatible capsules containing cells
GB929207143A GB9207143D0 (en) 1992-04-01 1992-04-01 A method of making biocompatible capsules containing cells

Publications (1)

Publication Number Publication Date
ES2101863T3 true ES2101863T3 (es) 1997-07-16

Family

ID=26299426

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92917748T Expired - Lifetime ES2101863T3 (es) 1991-08-20 1992-08-14 Procedimiento para la produccion de capsulas biocompatibles que contienen celulas.

Country Status (13)

Country Link
US (1) US5529913A (es)
EP (1) EP0599942B1 (es)
JP (1) JPH06510035A (es)
AT (1) ATE152616T1 (es)
AU (1) AU2443392A (es)
CA (1) CA2115664A1 (es)
DE (1) DE69219606T2 (es)
DK (1) DK0599942T3 (es)
ES (1) ES2101863T3 (es)
GR (1) GR3024007T3 (es)
IL (1) IL102785A (es)
MX (1) MX9204831A (es)
WO (1) WO1993003710A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9414304D0 (en) * 1994-07-15 1994-09-07 C V Lab Ltd Fibres, manufacture and use
WO2000031267A1 (en) * 1998-11-20 2000-06-02 The Autonomous University Of Barcelona Insulin production by engineered muscle cells
US6921412B1 (en) 1999-05-18 2005-07-26 Cryolife, Inc. Self-supporting, shaped, three-dimensional biopolymeric materials and methods
EP1250165B1 (en) * 2000-01-25 2009-05-13 Edwards Lifesciences Corporation Bioactive coatings to prevent tissue overgrowth on artificial heart valves
CA2421036A1 (en) 2000-09-20 2002-03-28 Islet Sheet Medical Llc Fabrication of thin sheet bio-artificial organs
EP1416946B1 (en) * 2000-11-07 2017-12-20 CryoLife, Inc. Expandable foam-like biomaterials and methods
US20060246111A1 (en) * 2005-04-19 2006-11-02 Smith Larry L Polysaccharides as ultrasound transmission media
MX2013011040A (es) * 2011-03-29 2014-08-22 Beta Cell Nv Metodo para productos terapeuticos encapsulados y usos de los mismos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.
EP0301777A1 (en) * 1987-07-28 1989-02-01 Queen's University At Kingston Multiple membrane microencapsulation
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules

Also Published As

Publication number Publication date
DE69219606D1 (de) 1997-06-12
IL102785A (en) 1998-06-15
DE69219606T2 (de) 1997-09-04
AU2443392A (en) 1993-03-16
EP0599942A1 (en) 1994-06-08
GR3024007T3 (en) 1997-10-31
JPH06510035A (ja) 1994-11-10
DK0599942T3 (da) 1997-11-03
WO1993003710A1 (en) 1993-03-04
CA2115664A1 (en) 1993-03-04
MX9204831A (es) 1993-07-01
ATE152616T1 (de) 1997-05-15
IL102785A0 (en) 1993-01-31
EP0599942B1 (en) 1997-05-07
US5529913A (en) 1996-06-25

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