ES2101483T3 - Derivados de benzo(d)isoxazoles condensados y su uso como agentes psicoactivos. - Google Patents

Derivados de benzo(d)isoxazoles condensados y su uso como agentes psicoactivos.

Info

Publication number
ES2101483T3
ES2101483T3 ES94900972T ES94900972T ES2101483T3 ES 2101483 T3 ES2101483 T3 ES 2101483T3 ES 94900972 T ES94900972 T ES 94900972T ES 94900972 T ES94900972 T ES 94900972T ES 2101483 T3 ES2101483 T3 ES 2101483T3
Authority
ES
Spain
Prior art keywords
pct
hydrogen
date jul
isoxazoles
benzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94900972T
Other languages
English (en)
Inventor
Edwardandrew Boyd
Brenda Costall
Mary Elizabeth Kelly
Philip James Northcour Parsons
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Application granted granted Critical
Publication of ES2101483T3 publication Critical patent/ES2101483T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

SE PRESENTAN COMPUESTOS DE LA FORMULA (I) EN LA CUAL X REPRESENTA UN GRUPO (A), (B), (C) O (D) EN DONDE R ES HIDROGENO, ALQUIL C1-C6, FENIL O FENILALQUIL C7-C12, R1 Y R2 REPRESENTAN CADA UNA HIDROGENO O JUNTAS REPRESENTAN UN GRUPO OXO Y R3, R4 Y R5 REPRESENTAN CADA UNA HIDROGENO O R1 REPRESENTA HIDROGENO Y DOS DE ENTRE R2, R3, R4 Y R5 JUNTAS REPRESENTAN EL SEGUNDO ENLACE DE LAS POSICIONES DE UNION DE ENLACE DOBLE 7 Y 8, 8 Y 9 O 9 Y 10 CON LAS RESTANTES DOS DE R2, R4, R4 Y R5 QUE REPRESENTAN HIDROGENO, EL COMPUESTO OPCIONALMENTE TIENE LA FORMA DE UNA SAL DEL MISMO FORMADA CON UN ACIDO ORGANICO O INORGANICO FISIOLOGICAMENTE ACEPTABLE, LOS COMPUESTOS SON VALIOSOS PARA EL TRATAMIENTO DE LA ANSIEDAD Y EN LA MEJORA DE LA CAPACIDAD DE CONOCIMIENTO Y/O LA INVERSION DE LA AMNESIA.
ES94900972T 1992-12-23 1993-12-07 Derivados de benzo(d)isoxazoles condensados y su uso como agentes psicoactivos. Expired - Lifetime ES2101483T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929226857A GB9226857D0 (en) 1992-12-23 1992-12-23 Pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ES2101483T3 true ES2101483T3 (es) 1997-07-01

Family

ID=10727141

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94900972T Expired - Lifetime ES2101483T3 (es) 1992-12-23 1993-12-07 Derivados de benzo(d)isoxazoles condensados y su uso como agentes psicoactivos.

Country Status (15)

Country Link
US (1) US5707988A (es)
EP (1) EP0675890B1 (es)
JP (1) JP3542803B2 (es)
KR (1) KR100320996B1 (es)
AT (1) ATE151427T1 (es)
AU (1) AU680645B2 (es)
CA (1) CA2152284C (es)
DE (1) DE69309714T2 (es)
DK (1) DK0675890T3 (es)
ES (1) ES2101483T3 (es)
GB (2) GB9226857D0 (es)
GR (1) GR3023744T3 (es)
IL (1) IL108135A (es)
WO (1) WO1994014816A1 (es)
ZA (1) ZA939665B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0313628D0 (en) * 2003-06-12 2003-07-16 Btg Int Ltd Psychoactive compounds
BRPI0411124A (pt) * 2003-06-12 2006-07-18 Btg Int Ltd hidroxilamina cìclica como compostos psicoativos
TW201020233A (en) * 2008-10-09 2010-06-01 Kyorin Seiyaku Kk Isoquinoline derivative, and pde inhibitor comprising same as active ingredient

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1540580A (en) * 1975-09-02 1979-02-14 Shell Int Research Fungicidal isoxazolidines
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US5049564A (en) * 1989-11-17 1991-09-17 Abbott Laboratories 5-HT selective agents
ATE104968T1 (de) * 1989-05-24 1994-05-15 Pharmacia Ab Substituierte isoxazolidine und isoxazoline.
US5114936A (en) * 1990-08-23 1992-05-19 Hoechst-Roussel Pharmaceuticals Incorporated 6,7-dihydro-3-phenyl-1,2-benzisoxazol-4(5h)-ones and -ols, compositions and pharmaceutical use
GB2264299B (en) * 1992-02-19 1995-07-26 British Tech Group Iso-oxazolidine derivatives

Also Published As

Publication number Publication date
EP0675890B1 (en) 1997-04-09
CA2152284C (en) 2006-01-17
DE69309714T2 (de) 1997-08-21
GB9226857D0 (en) 1993-02-17
GB2273706B (en) 1996-06-05
DK0675890T3 (da) 1997-05-05
AU680645B2 (en) 1997-08-07
GR3023744T3 (en) 1997-09-30
KR100320996B1 (ko) 2002-07-27
EP0675890A1 (en) 1995-10-11
GB9325044D0 (en) 1994-02-02
GB2273706A (en) 1994-06-29
AU5573394A (en) 1994-07-19
CA2152284A1 (en) 1994-07-07
WO1994014816A1 (en) 1994-07-07
KR960700249A (ko) 1996-01-19
DE69309714D1 (de) 1997-05-15
ATE151427T1 (de) 1997-04-15
IL108135A0 (en) 1994-08-26
US5707988A (en) 1998-01-13
IL108135A (en) 1998-04-05
JPH08504796A (ja) 1996-05-21
JP3542803B2 (ja) 2004-07-14
ZA939665B (en) 1995-06-23

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