ES2099994T3 - Procedimiento para la preparacion de carboxamidas de heterociclos aromaticos con contenido en nitrogeno. - Google Patents

Procedimiento para la preparacion de carboxamidas de heterociclos aromaticos con contenido en nitrogeno.

Info

Publication number
ES2099994T3
ES2099994T3 ES94108389T ES94108389T ES2099994T3 ES 2099994 T3 ES2099994 T3 ES 2099994T3 ES 94108389 T ES94108389 T ES 94108389T ES 94108389 T ES94108389 T ES 94108389T ES 2099994 T3 ES2099994 T3 ES 2099994T3
Authority
ES
Spain
Prior art keywords
carboxamides
cycle
procedure
preparation
nitrogen content
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94108389T
Other languages
English (en)
Inventor
Jean-Paul Dr Roduit
Alain Wellig
Karin Amacker
Martin Dr Eyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Application granted granted Critical
Publication of ES2099994T3 publication Critical patent/ES2099994T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Quinoline Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA ELABORACION DE CARBOXAMIDAS DE HETEROCICLOS AROMATICOS QUE CONTIENEN NITROGENO A PARTIR DE LOS CORRESPONDIENTES N CION CON FORMAMIDA, EN PRESENCIA DE ACIDO PEROXO Y SULFURICO O UN DISULFATO PEROXO.
ES94108389T 1993-06-01 1994-05-31 Procedimiento para la preparacion de carboxamidas de heterociclos aromaticos con contenido en nitrogeno. Expired - Lifetime ES2099994T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH163093 1993-06-01

Publications (1)

Publication Number Publication Date
ES2099994T3 true ES2099994T3 (es) 1997-06-01

Family

ID=4214940

Family Applications (2)

Application Number Title Priority Date Filing Date
ES96107208T Expired - Lifetime ES2174995T3 (es) 1993-06-01 1994-05-31 Procedimiento para la preparacion de acidos carboxilicos de heterociclos aromaticos con contenido en nitrogeno.
ES94108389T Expired - Lifetime ES2099994T3 (es) 1993-06-01 1994-05-31 Procedimiento para la preparacion de carboxamidas de heterociclos aromaticos con contenido en nitrogeno.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES96107208T Expired - Lifetime ES2174995T3 (es) 1993-06-01 1994-05-31 Procedimiento para la preparacion de acidos carboxilicos de heterociclos aromaticos con contenido en nitrogeno.

Country Status (10)

Country Link
US (1) US5614636A (es)
EP (2) EP0728744B1 (es)
JP (2) JP3493727B2 (es)
AT (2) ATE215933T1 (es)
CA (2) CA2123731C (es)
DE (2) DE59402341D1 (es)
DK (2) DK0728744T3 (es)
ES (2) ES2174995T3 (es)
GR (1) GR3023095T3 (es)
PT (1) PT728744E (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59711086D1 (de) * 1996-03-21 2004-01-22 Lonza Ag Verfahren zur Herstellung von Arylamiden Heteroaromatischer Carbonsäuren
SK283920B6 (sk) 1996-03-28 2004-05-04 Lonza Ag Spôsob výroby arylamidov heteroaromatických karboxylových kyselín
ES2143816T3 (es) * 1996-05-09 2000-05-16 Lonza Ag Procedimiento para la preparacion de arilamidas de acidos carboxilicos heteroaromaticos.
US5900484A (en) * 1996-09-18 1999-05-04 Lonza Ag Process for the preparation of arylamides of heteroaromatic carboxylic acids
CA2209392C (en) * 1996-07-23 2007-02-20 Yves Bessard Process for preparing pyridinecarboxylic esters
CN110981795B (zh) * 2019-12-18 2021-02-12 武汉世纪久海检测技术有限公司 一种利用2-氰基异烟酸甲酯制备2-氨酰基异烟酸的方法
CN115477638A (zh) * 2022-10-09 2022-12-16 浙江神洲药业有限公司 一种托匹司他的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2780624A (en) * 1953-01-29 1957-02-05 American Cyanamid Co Process of producing pyrazinamide
BE759237A (fr) * 1969-11-21 1971-05-01 Montedison Spa Procede de preparation d'amides a partir de composes heterocycliques azotes
JPS5817462B2 (ja) * 1974-09-11 1983-04-07 昭和電工株式会社 ピリジンカルボンサンアミド ノ セイゾウホウ
US4496736A (en) * 1981-06-23 1985-01-29 Bayer Aktiengesellschaft Process for the preparation of carboxylic acids and N-tert.-alkylamines

Also Published As

Publication number Publication date
EP0627422A2 (de) 1994-12-07
JP3493727B2 (ja) 2004-02-03
EP0728744B1 (de) 2002-04-10
EP0627422A3 (de) 1995-03-22
ATE215933T1 (de) 2002-04-15
CA2123731C (en) 2006-07-11
ATE151417T1 (de) 1997-04-15
ES2174995T3 (es) 2002-11-16
DK0728744T3 (da) 2002-07-29
CA2123731A1 (en) 1994-12-02
EP0627422B1 (de) 1997-04-09
PT728744E (pt) 2002-09-30
US5614636A (en) 1997-03-25
CA2539969C (en) 2009-07-07
DE59410101D1 (de) 2002-05-16
CA2539969A1 (en) 1994-12-02
JPH06340632A (ja) 1994-12-13
EP0728744A2 (de) 1996-08-28
DK0627422T3 (es) 1997-05-05
EP0728744A3 (de) 1996-11-27
GR3023095T3 (en) 1997-07-30
DE59402341D1 (de) 1997-05-15
JP2004043491A (ja) 2004-02-12
JP3858876B2 (ja) 2006-12-20

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