ES2097808T3 - Anticuerpos de marco conservado mutado y su preparacion. - Google Patents
Anticuerpos de marco conservado mutado y su preparacion.Info
- Publication number
- ES2097808T3 ES2097808T3 ES91907669T ES91907669T ES2097808T3 ES 2097808 T3 ES2097808 T3 ES 2097808T3 ES 91907669 T ES91907669 T ES 91907669T ES 91907669 T ES91907669 T ES 91907669T ES 2097808 T3 ES2097808 T3 ES 2097808T3
- Authority
- ES
- Spain
- Prior art keywords
- preserved
- antibodies
- preparation
- derived
- framework
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE PRODUCE UNA CADENA DE ANTICUERPOS ALTERADA EN QUE LOS CDRS DEL DOMINIO VARIABLE DE LA CADENA SE DERIVAN DE UNA PRIMERA ESPECIE DE MAMIFEROS. LAS REGIONES QUE CODIFICAN EL SOPORTE DE ADN QUE CODIFICA EL DOMINIO VARIABLE DE LA PRIMERA ESPECIE SE MUTAN DE TAL COMO DE LAS REGIONES QUE CODIFICAN EL SOPORTE MUTADAS CODIFICAN UN SOPORTE DERIVADO DE UNA SEGUNDA ESPECIE DE MAMIFEROS. EL DOMINIO O CADA UNO DE LOS DOMINIOS CONSTANTES DE LA CADENA DEL ANTICUERPO, SI SE ENCONTRARA PRESENTE, SE DERIVAN TAMBIEN DE LA SEGUNDA ESPECIE DE MAMIFEROS. TAMBIEN SE PRESENTA UN ANTICUERPO CAPAZ DE ENLAZARSE A UN ANTIGENO CD4 HUMANO JUNTO CON UNA COMPOSICION FARMACEUTICA QUE CONTIENE EL ANTICUERPO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909020282A GB9020282D0 (en) | 1990-09-17 | 1990-09-17 | Altered antibodies and their preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2097808T3 true ES2097808T3 (es) | 1997-04-16 |
Family
ID=10682322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91907669T Expired - Lifetime ES2097808T3 (es) | 1990-09-17 | 1991-09-16 | Anticuerpos de marco conservado mutado y su preparacion. |
Country Status (20)
Country | Link |
---|---|
US (5) | USRE46877E1 (es) |
EP (1) | EP0549581B2 (es) |
JP (1) | JPH06502762A (es) |
KR (1) | KR100217212B1 (es) |
AT (1) | ATE148172T1 (es) |
AU (1) | AU660151B2 (es) |
CA (1) | CA2091769C (es) |
DE (1) | DE69124387T3 (es) |
DK (1) | DK0549581T3 (es) |
ES (1) | ES2097808T3 (es) |
GB (1) | GB9020282D0 (es) |
GR (1) | GR3023252T3 (es) |
ID (1) | ID1044B (es) |
IE (1) | IE913257A1 (es) |
IL (1) | IL99499A (es) |
MX (1) | MX9101117A (es) |
MY (1) | MY111682A (es) |
NZ (1) | NZ239826A (es) |
WO (1) | WO1992005274A1 (es) |
ZA (1) | ZA917407B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9020282D0 (en) * | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
GB9206422D0 (en) * | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
CA2221350A1 (en) * | 1995-05-18 | 1996-11-21 | Ortho Pharmaceutical Corporation | Induction of immunological tolerance by the use of non-depleting anti-cd4 antibodies |
US6228360B1 (en) * | 1998-08-19 | 2001-05-08 | Ajinomoto Co., Inc. | Antithrombotic agent and humanized anti-von Willebrand factor monoclonal antibody |
US6972324B2 (en) | 2001-05-18 | 2005-12-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Antibodies specific for CD44v6 |
YU91403A (sh) * | 2001-05-18 | 2006-05-25 | Boehringer Ingelheim International Gmbh. | Antitela specifična za cd44v6 |
GB2376466A (en) * | 2001-06-14 | 2002-12-18 | Mark Frewin | TRX1 antibody |
US8165535B2 (en) * | 2006-06-04 | 2012-04-24 | Samsung Electro-Mechanics | Systems, methods and apparatuses for complementary metal oxide semiconductor (CMOS) antenna switches using switched resonators |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
WO2004065417A2 (en) * | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
ES2324538T3 (es) | 2003-12-05 | 2009-08-10 | Multimmune Gmbh | Anticuerpos anti-hsp terapeuticos y de diagnostico. |
EP2336177A1 (en) * | 2004-08-04 | 2011-06-22 | Amgen, Inc | Antibodies to DKK-1 |
AP2007004250A0 (en) * | 2005-05-24 | 2007-12-31 | Avestha Gengraine Tech Pvt Ltd | Recombinant method for the production of a monoclonal antibody to cd52 for the treatment of chronic lymphocytic leukemia |
SG177954A1 (en) | 2007-01-05 | 2012-02-28 | Univ Zuerich | Method of providing disease-specific binding molecules and targets |
PT2457928T (pt) | 2007-03-13 | 2017-08-17 | Univ Zuerich | Anticorpo monoclonal humano específico de tumores |
EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
WO2009033743A1 (en) | 2007-09-13 | 2009-03-19 | University Of Zurich Prorektorat Forschung | Monoclonal amyloid beta (abeta)-specific antibody and uses thereof |
EP2352764B1 (en) | 2008-10-14 | 2018-03-28 | Ablynx N.V. | AMINO ACID SEQUENCES TARGETING HUMAN CD4 and CXCR4, CCR5, TLR4, ALPHAV INTEGRIN, BETA3-INTEGRIN,BETA1-INTEGRIN, HUMAN ALPHA2-INTEGRIN, CD81, SR-BI, CLAUDIN-1, CLAUDIN-6 AND/OR CLAUDIN-9, RESPECTIVELY, AND NEUTRALIZING VIRAL ENTRY |
US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
EP2509409B1 (en) | 2009-12-10 | 2016-07-27 | Regeneron Pharmaceuticals, Inc. | Mice that make heavy chain antibodies |
DE202011103324U1 (de) | 2011-07-12 | 2012-01-02 | Nekonal S.A.R.L. | Therapeutische anti-TIRC7 Antikörper für die Verwendung in Immun und anderen Krankheiten |
CN109265543B (zh) | 2011-09-19 | 2022-04-26 | 阿克松神经系统科学公司 | 阿尔茨海默病中的tau蛋白介导病变的基于蛋白质的疗法和诊断 |
EP2771694A4 (en) | 2011-10-26 | 2015-08-05 | Novartis Tiergesundheit Ag | MONOCLONAL ANTIBODIES AND METHOD FOR THEIR USE |
US20150030602A1 (en) | 2011-12-23 | 2015-01-29 | Phenoquest Ag | Antibodies for the treatment and diagnosis of affective and anxiety disorders |
CA2861793C (en) | 2011-12-28 | 2023-08-01 | Immunoqure Ag | Method of providing monoclonal auto-antibodies with desired specificity |
US10112995B2 (en) | 2013-07-03 | 2018-10-30 | Immunoqure Ag | Human anti-IFN-α antibodies |
US8883157B1 (en) | 2013-12-17 | 2014-11-11 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
US9914769B2 (en) | 2014-07-15 | 2018-03-13 | Kymab Limited | Precision medicine for cholesterol treatment |
US9139648B1 (en) | 2014-07-15 | 2015-09-22 | Kymab Limited | Precision medicine by targeting human NAV1.9 variants for treatment of pain |
WO2022153212A1 (en) | 2021-01-13 | 2022-07-21 | Axon Neuroscience Se | Antibodies neutralizing sars-cov-2 |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652447A (en) | 1979-04-26 | 1987-03-24 | Ortho Pharmaceutical Corporation | Methods and compositions using monoclonal antibody to human helper T cells |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US4695459A (en) | 1984-12-26 | 1987-09-22 | The Board Of Trustees Of Leland Stanford Junior University | Method of treating autoimmune diseases that are mediated by Leu3/CD4 phenotype T cells |
US4681760A (en) | 1985-04-17 | 1987-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of conferring immunotolerance to a specific antigen |
US6548640B1 (en) * | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
EP0623679B1 (en) | 1987-05-21 | 2003-06-25 | Micromet AG | Targeted multifunctional proteins |
AU625613B2 (en) | 1988-01-05 | 1992-07-16 | Novartis Ag | Novel chimeric antibodies |
JP2646007B2 (ja) | 1988-01-30 | 1997-08-25 | 財団法人 化学及血清療法研究所 | 抗hiv抗体可変領域をコードする遺伝子断片およびこれらを用いて発現された抗hivキメラ抗体ならびにその製法 |
DE68909441T2 (de) | 1988-02-12 | 1994-02-10 | British Tech Group | Modifizierte Antikörper. |
AU631545B2 (en) | 1988-04-15 | 1992-12-03 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
EP0365209A3 (en) | 1988-10-17 | 1990-07-25 | Becton, Dickinson and Company | Anti-leu 3a amino acid sequence |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE69020914T2 (de) | 1989-01-23 | 1996-03-07 | Abbott Lab | Monoklonale Antikörper von Ratten gegen menschliche Antigene und Verfahren zu deren Herstellung. |
CA2018248A1 (en) | 1989-06-07 | 1990-12-07 | Clyde W. Shearman | Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use |
JPH0353894A (ja) | 1989-07-21 | 1991-03-07 | Calpis Food Ind Co Ltd:The | 抗ヒトcd4ペプチドに対するモノクローナル抗体 |
GB8925590D0 (en) | 1989-11-13 | 1990-01-04 | Central Blood Lab Authority | Monoclonal antibodies |
GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GB9020282D0 (en) * | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
CA2103059C (en) * | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
GB9125979D0 (en) * | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
-
1990
- 1990-09-17 GB GB909020282A patent/GB9020282D0/en active Pending
-
1991
- 1991-09-16 AT AT91907669T patent/ATE148172T1/de not_active IP Right Cessation
- 1991-09-16 IL IL99499A patent/IL99499A/en not_active IP Right Cessation
- 1991-09-16 US US13/683,113 patent/USRE46877E1/en not_active Expired - Lifetime
- 1991-09-16 US US08/030,175 patent/US6767996B1/en not_active Ceased
- 1991-09-16 CA CA002091769A patent/CA2091769C/en not_active Expired - Lifetime
- 1991-09-16 IE IE325791A patent/IE913257A1/en unknown
- 1991-09-16 ES ES91907669T patent/ES2097808T3/es not_active Expired - Lifetime
- 1991-09-16 EP EP91907669A patent/EP0549581B2/en not_active Expired - Lifetime
- 1991-09-16 DE DE69124387T patent/DE69124387T3/de not_active Expired - Lifetime
- 1991-09-16 WO PCT/GB1991/001578 patent/WO1992005274A1/en active IP Right Grant
- 1991-09-16 US US11/493,016 patent/USRE43898E1/en not_active Expired - Lifetime
- 1991-09-16 JP JP3516449A patent/JPH06502762A/ja active Pending
- 1991-09-16 AU AU85088/91A patent/AU660151B2/en not_active Expired
- 1991-09-16 DK DK91907669.5T patent/DK0549581T3/da active
- 1991-09-16 KR KR1019930700786A patent/KR100217212B1/ko not_active IP Right Cessation
- 1991-09-17 MX MX9101117A patent/MX9101117A/es unknown
- 1991-09-17 ZA ZA917407A patent/ZA917407B/xx unknown
- 1991-09-17 MY MYPI91001686A patent/MY111682A/en unknown
- 1991-09-17 NZ NZ239826A patent/NZ239826A/xx not_active IP Right Cessation
- 1991-10-17 ID IDP61891A patent/ID1044B/id unknown
-
1995
- 1995-06-02 US US08/459,655 patent/US7098006B1/en not_active Expired - Lifetime
-
1997
- 1997-04-22 GR GR970400917T patent/GR3023252T3/el unknown
-
2005
- 2005-04-26 US US11/114,233 patent/US20070212753A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU660151B2 (en) | 1995-06-15 |
GB9020282D0 (en) | 1990-10-31 |
IL99499A (en) | 2006-08-20 |
ID1044B (id) | 1996-10-28 |
DE69124387D1 (de) | 1997-03-06 |
KR100217212B1 (ko) | 1999-10-01 |
JPH06502762A (ja) | 1994-03-31 |
US20070212753A1 (en) | 2007-09-13 |
CA2091769C (en) | 2002-07-23 |
AU8508891A (en) | 1992-04-15 |
CA2091769A1 (en) | 1992-03-18 |
US7098006B1 (en) | 2006-08-29 |
EP0549581B2 (en) | 2010-04-28 |
MX9101117A (es) | 1992-05-04 |
KR930702535A (ko) | 1993-09-09 |
IL99499A0 (en) | 1992-08-18 |
USRE43898E1 (en) | 2013-01-01 |
EP0549581A1 (en) | 1993-07-07 |
DK0549581T3 (da) | 1997-05-26 |
NZ239826A (en) | 1992-12-23 |
EP0549581B1 (en) | 1997-01-22 |
ATE148172T1 (de) | 1997-02-15 |
WO1992005274A1 (en) | 1992-04-02 |
US6767996B1 (en) | 2004-07-27 |
ZA917407B (en) | 1992-06-24 |
USRE46877E1 (en) | 2018-05-29 |
MY111682A (en) | 2000-11-30 |
DE69124387T3 (de) | 2011-02-17 |
GR3023252T3 (en) | 1997-07-30 |
DE69124387T2 (de) | 1997-05-15 |
IE913257A1 (en) | 1992-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2097808T3 (es) | Anticuerpos de marco conservado mutado y su preparacion. | |
ATE95068T1 (de) | Modifizierte antikoerper. | |
AU5055593A (en) | Antibodies specific for HIV | |
DK0414475T3 (da) | Fremgangsmåder til dyrkning af HCV i B- eller T-lymfocyt-cellelinier | |
ATE161582T1 (de) | Monoklonale antikörper der maus | |
ES2116789T3 (es) | Anticuerpos monoclonales (mak) contra antigenos asociados a tumores, su preparacion y empleo. | |
ATE160575T1 (de) | Für toxin b von clostridium difficile spezifische monoklonale antikörper | |
GR3029483T3 (en) | Antibodies against t-cells as therapeutics | |
DE3585049D1 (de) | Monoklonale antikoerper. | |
JPS6461499A (en) | Monoclonal antibody to human papilloma viruses 16 type e7 protein, and production and use thereof | |
CA2095735A1 (en) | Monoclonal antibodies to hepatitis c virus and method for using same | |
ATE58397T1 (de) | Monoklonaler antikoerper geeignet zur spezifischen unterscheidung von humanen hepatokarzinomzellen. | |
DE69111429D1 (de) | Monoklonale antikörper, die einen unterschied zwischen nativproteinen und proteinen mit einer modifizierten sequenz machen. | |
DE69124317D1 (de) | Monoklonale Antikörper gegen Leptosphaeria | |
ATE133266T1 (de) | Nachweis von viralen oder bakteriellen antigenen mittels durchflusscytometrie | |
DE69124294D1 (de) | Monoklonale Antikörper gegen Mycosphaerella-Arten | |
IT8821547A0 (it) | Metodo immunologico per la determinazione di anticorpi anti antigeni di microorganismi, mediante anticorpi antiidiotipo e mezzi adatti allo scopo. | |
BG48881A1 (en) | Hybridomic cell line mus musculus h 5/9, secretizing monoclonal antibodies against rickettsia conorii | |
ATE92102T1 (de) | Genfragmente, die die variable region eines anti- hiv-antikoerpers codieren, von diesen exprimierte chimaere anti-hiv-antikoerper und verfahren zu deren herstellung. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 549581 Country of ref document: ES |