ES2096646T3 - Liposomas y geles por interdigitalizacion-fusion. - Google Patents
Liposomas y geles por interdigitalizacion-fusion.Info
- Publication number
- ES2096646T3 ES2096646T3 ES91903087T ES91903087T ES2096646T3 ES 2096646 T3 ES2096646 T3 ES 2096646T3 ES 91903087 T ES91903087 T ES 91903087T ES 91903087 T ES91903087 T ES 91903087T ES 2096646 T3 ES2096646 T3 ES 2096646T3
- Authority
- ES
- Spain
- Prior art keywords
- liposomes
- gels
- present
- fusion
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
ESTA INVENCION ESTA RELACIONADA CON LIPOSOMAS Y GELES DE INTERDIGITACION-FUSION (IF). ESTOS LIPOSOMAS Y GELES CAPTURAN SOLUTO ALTO RESPECTO A PROPORCIONES DE LIPIDOS, QUE INCLUYE AGENTE BIOACTIVO. ESTA INVENCION TAMBIEN ESTA RELACIONADA CON EL DESCUBRIMIENTO DE QUE LA FUSION DE LIPOSOMAS PARA PRODUCIR GEL Y LIPOSOMAS DE IF SEGUN LA PRESENTE INVENCION ES TAMAÑO DEPENDIENTE. LA PRESENTE INVENCION TAMBIEN ESTA RELACIONADA CON UN METODO PARA PRODUCIR LIPOSOMAS Y GELES DE IF. EN EL METODO DE LA PRESENTE INVENCION, LOS LIPOSOMAS DIMENSIONADOS FORMADOS POR SONICACION, EXTRUSION O PROCESOS ALTERNATIVOS SE FUNDEN EN PRESENCIA DE ETANOL U OTRO INDUCTOR ADECUADO. ESTE PROCESO TIENE COMO RESULTADO UNA COMPOSICION DE LA PRESENTE INVENCION EN FORMA DE GEL. PARA PRODUCIR LIPOSOMAS, SE EXPONEN LOS GELES A UNA TEMPERATURA NORMALMENTE, PERO NO NECESARIAMENTE, SUPERIOR A LA TEMPERATURA DE TRANSICION (TM) DEL LIPIDO UTILIZADO. LA TEMPERATURA NECESARIA POR LOS METODOS DE LA INVENCION ES AQUELLA TEMPERATURA QUEINDUCE UN CAMBIO EN LAS PROPIEDADES DEL MATERIAL DE LA MEZCLA. TAMBIEN SE PUEDE RETIRAR EL INDUCTOR. EL RESULTADO ES UNA COMPOSICION QUE COMPRENDE LIPOSOMAS QUE CONTIENEN SOLUTO ALTO RESPECTO A LAS PROPORCIONES DE LIPIDOS. LOS LIPOSOMAS Y GELES DE IF DE LA PRESENTE INVENCION SE PUEDEN UTILIZAR EN COMBINACION CON NUMEROSOS SOLUTOS, INCLUYENDO ESPECIALMENTE LOS AGENTES BIOACTIVOS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46452890A | 1990-01-12 | 1990-01-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2096646T3 true ES2096646T3 (es) | 1997-03-16 |
Family
ID=23844291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91903087T Expired - Lifetime ES2096646T3 (es) | 1990-01-12 | 1991-01-11 | Liposomas y geles por interdigitalizacion-fusion. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0510086B1 (es) |
| JP (1) | JP3131923B2 (es) |
| KR (1) | KR920703015A (es) |
| AT (1) | ATE146074T1 (es) |
| AU (1) | AU652552B2 (es) |
| CA (1) | CA2073431C (es) |
| DE (1) | DE69123568T2 (es) |
| DK (1) | DK0510086T3 (es) |
| ES (1) | ES2096646T3 (es) |
| GR (1) | GR3022701T3 (es) |
| HK (1) | HK1007499A1 (es) |
| IE (1) | IE910086A1 (es) |
| NO (1) | NO305535B1 (es) |
| PT (1) | PT96465B (es) |
| WO (1) | WO1991010422A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5882678A (en) * | 1990-01-12 | 1999-03-16 | The Liposome Co, Inc. | Interdigitation-fusion liposomes containing arachidonic acid metabolites |
| US5820848A (en) * | 1990-01-12 | 1998-10-13 | The Liposome Company, Inc. | Methods of preparing interdigitation-fusion liposomes and gels which encapsulate a bioactive agent |
| US6623671B2 (en) | 1990-10-05 | 2003-09-23 | Royden M. Coe | Liposome extrusion process |
| WO1992005772A1 (en) * | 1990-10-05 | 1992-04-16 | The Liposome Company, Inc. | Liposome extrusion process |
| IT1255476B (it) * | 1992-07-30 | 1995-11-02 | Glicerofosfoderivati farmacologicamente attivi | |
| MX9306373A (es) * | 1992-10-14 | 1994-06-30 | Liposome Co Inc | Liposomas y geles de fusion por interdigitacion. |
| WO1995013797A1 (en) * | 1993-11-16 | 1995-05-26 | The Liposome Company, Inc. | Interdigitation-fusion liposomes containing arachidonic acid metabolites |
| US5716526A (en) * | 1994-01-14 | 1998-02-10 | The Liposome Company, Inc. | Method of separating materials from liposomes or lipid complexes |
| CN1148812A (zh) * | 1994-03-28 | 1997-04-30 | 尼科梅德成像有限公司 | “脂质体” |
| WO1996016980A1 (en) * | 1994-11-29 | 1996-06-06 | Novartis Ag | Morpholinoethylamide derivatives |
| US6613352B2 (en) | 1999-04-13 | 2003-09-02 | Universite De Montreal | Low-rigidity liposomal formulation |
| GR20180100082A (el) * | 2018-02-28 | 2019-09-25 | ΝΙΚΟΛΑΟΣ Α. ΦΙΚΙΩΡΗΣ ΚΑΙ ΣΙΑ ΕΤΑΙΡΕΙΑ ΠΕΡΙΟΡΙΣΜΕΝΗΣ ΕΥΘΗΝΗΣ με δ.τ. IN TOUCH HEALTH Ε.Π.Ε | Μεθοδος για την παραγωγη οχηματων μεταφορας λιπιδιων |
| CN111387339B (zh) * | 2020-02-20 | 2022-11-25 | 浙江工商大学 | 一种具有仿母乳脂肪球结构的大尺寸脂质体及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4515736A (en) * | 1983-05-12 | 1985-05-07 | The Regents Of The University Of California | Method for encapsulating materials into liposomes |
| JPS59218956A (ja) * | 1983-05-27 | 1984-12-10 | Fujirebio Inc | 膜融合測定方法 |
| US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4789633A (en) * | 1984-04-19 | 1988-12-06 | University Of Tennessee Research Corporation | Fused liposome and acid induced method for liposome fusion |
| US4921706A (en) * | 1984-11-20 | 1990-05-01 | Massachusetts Institute Of Technology | Unilamellar lipid vesicles and method for their formation |
| JPH0751496B2 (ja) * | 1986-04-02 | 1995-06-05 | 武田薬品工業株式会社 | リポソ−ムの製造法 |
| US4962022A (en) * | 1986-09-22 | 1990-10-09 | Becton Dickinson And Company | Storage and use of liposomes |
| US4944948A (en) * | 1989-02-24 | 1990-07-31 | Liposome Technology, Inc. | EGF/Liposome gel composition and method |
-
1991
- 1991-01-11 ES ES91903087T patent/ES2096646T3/es not_active Expired - Lifetime
- 1991-01-11 WO PCT/US1991/000259 patent/WO1991010422A1/en active IP Right Grant
- 1991-01-11 DE DE69123568T patent/DE69123568T2/de not_active Expired - Fee Related
- 1991-01-11 CA CA002073431A patent/CA2073431C/en not_active Expired - Fee Related
- 1991-01-11 KR KR1019920701613A patent/KR920703015A/ko not_active Application Discontinuation
- 1991-01-11 AU AU71817/91A patent/AU652552B2/en not_active Ceased
- 1991-01-11 DK DK91903087.4T patent/DK0510086T3/da active
- 1991-01-11 EP EP91903087A patent/EP0510086B1/en not_active Expired - Lifetime
- 1991-01-11 IE IE008691A patent/IE910086A1/en not_active IP Right Cessation
- 1991-01-11 PT PT96465A patent/PT96465B/pt not_active IP Right Cessation
- 1991-01-11 AT AT91903087T patent/ATE146074T1/de not_active IP Right Cessation
- 1991-01-11 JP JP03503398A patent/JP3131923B2/ja not_active Expired - Fee Related
-
1992
- 1992-07-10 NO NO922735A patent/NO305535B1/no unknown
-
1997
- 1997-02-27 GR GR970400387T patent/GR3022701T3/el unknown
-
1998
- 1998-06-25 HK HK98106750A patent/HK1007499A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| GR3022701T3 (en) | 1997-05-31 |
| DK0510086T3 (da) | 1997-06-09 |
| WO1991010422A1 (en) | 1991-07-25 |
| CA2073431C (en) | 1999-05-25 |
| AU652552B2 (en) | 1994-09-01 |
| EP0510086A4 (en) | 1993-03-17 |
| DE69123568T2 (de) | 1997-05-28 |
| ATE146074T1 (de) | 1996-12-15 |
| EP0510086B1 (en) | 1996-12-11 |
| NO305535B1 (no) | 1999-06-21 |
| PT96465A (pt) | 1991-10-15 |
| CA2073431A1 (en) | 1991-07-13 |
| JPH05503521A (ja) | 1993-06-10 |
| KR920703015A (ko) | 1992-12-17 |
| DE69123568D1 (de) | 1997-01-23 |
| PT96465B (pt) | 1998-06-30 |
| EP0510086A1 (en) | 1992-10-28 |
| HK1007499A1 (en) | 1999-04-16 |
| AU7181791A (en) | 1991-08-05 |
| NO922735D0 (no) | 1992-07-10 |
| JP3131923B2 (ja) | 2001-02-05 |
| IE910086A1 (en) | 1991-07-17 |
| NO922735L (no) | 1992-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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