ES2095878T3 - Un antagonista a la cck. - Google Patents

Un antagonista a la cck.

Info

Publication number
ES2095878T3
ES2095878T3 ES90912437T ES90912437T ES2095878T3 ES 2095878 T3 ES2095878 T3 ES 2095878T3 ES 90912437 T ES90912437 T ES 90912437T ES 90912437 T ES90912437 T ES 90912437T ES 2095878 T3 ES2095878 T3 ES 2095878T3
Authority
ES
Spain
Prior art keywords
inclusive
carbon atoms
group
alkyl group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90912437T
Other languages
English (en)
Inventor
Sun Hyuk Kim
Sylviane Moreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Bioscience Inc
Original Assignee
Ipsen Bioscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Bioscience Inc filed Critical Ipsen Bioscience Inc
Application granted granted Critical
Publication of ES2095878T3 publication Critical patent/ES2095878T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EN GENERAL, LA INVENCION DESCRIBE UNOS COMPUESTOS QUE TIENEN LA FORMULA (I) O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES, DONDE AR ES INDOLILO, QUINOLILO, NAFTILO; M ES UN ENTERO ENTRE 0 Y 2, INCLUSIVE; Y A ES BIEN (ALFA), DONDE N ES UN ENTERO ENTRE 1 Y 5, INCLUSIVE, Y R (AL CUADRADO) ES HIDROXI, UN GRUPO ALCOXI TENIENDO 105, INCLUSIVE, ATOMOS DE CARBONO, ARALCOXI, O ARALQUILO.
ES90912437T 1989-08-21 1990-08-20 Un antagonista a la cck. Expired - Lifetime ES2095878T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/396,567 US5010089A (en) 1988-08-12 1989-08-21 CCK antagonists and their use in treating gastrointestinal disorders

Publications (1)

Publication Number Publication Date
ES2095878T3 true ES2095878T3 (es) 1997-03-01

Family

ID=23567756

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90912437T Expired - Lifetime ES2095878T3 (es) 1989-08-21 1990-08-20 Un antagonista a la cck.

Country Status (13)

Country Link
US (1) US5010089A (es)
EP (1) EP0489767B1 (es)
JP (1) JPH05500049A (es)
AT (1) ATE145405T1 (es)
CA (1) CA2064897A1 (es)
DE (1) DE69029198T2 (es)
DK (1) DK0489767T3 (es)
ES (1) ES2095878T3 (es)
GR (1) GR1001001B (es)
IE (1) IE903009A1 (es)
NO (1) NO920677L (es)
PT (1) PT95059B (es)
WO (1) WO1991002719A2 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
JP3361100B2 (ja) * 1994-03-10 2003-01-07 ワーナー−ランバート・コンパニー Ｃｃｋ受容体アンタゴニストとしてのインドール誘導体
JP3314938B2 (ja) * 1995-06-06 2002-08-19 ファイザー・インコーポレーテッド グリコーゲンホスホリラーゼ抑制剤としての置換されたｎ−（インドール−２−カルボニル）−グリシンアミド類および誘導体
MY114711A (en) 1995-06-06 2002-12-31 Pfizer Substituted n-(indole-2-carbonyl)-b-alanmamides and derivatives as antidiabetic agents
AP9600817A0 (en) 1995-06-06 1996-07-31 Pfizer Novel cryatal form of anhydrous 7-( [1A,5A,6A]-6-amino3-3-azabicyclo [3.1.0.] hex-3-yl) -6-fluro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1, 8-naphthyridine-3-carboxylic acid, methanesulfonic acid salt.
US6277877B1 (en) 2000-08-15 2001-08-21 Pfizer, Inc. Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4482567A (en) * 1982-10-07 1984-11-13 Research Foundation For Mental Hygiene, Inc. N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics
US4757151A (en) * 1985-11-14 1988-07-12 Warner-Lambert Company 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl]
US4814463A (en) * 1985-12-31 1989-03-21 Biomeasure, Inc. CCK antagonists
US4803284A (en) * 1987-08-19 1989-02-07 Centro De Investigacion Y De Estudios Avanzados Del Instituto Politecnico Nacional Processes for the preparation of 3-amino-2-(5-methoxy-1H-indol-3-yl) propionic acid monohydrate

Also Published As

Publication number Publication date
NO920677D0 (no) 1992-02-20
PT95059B (pt) 1997-12-31
IE903009A1 (en) 1991-02-27
JPH05500049A (ja) 1993-01-14
ATE145405T1 (de) 1996-12-15
GR1001001B (el) 1993-03-31
WO1991002719A2 (en) 1991-03-07
EP0489767A1 (en) 1992-06-17
US5010089A (en) 1991-04-23
PT95059A (pt) 1991-05-22
NO920677L (no) 1992-04-07
GR900100625A (en) 1991-12-30
EP0489767B1 (en) 1996-11-20
EP0489767A4 (en) 1992-07-08
WO1991002719A3 (en) 1991-04-04
DE69029198T2 (de) 1997-04-24
CA2064897A1 (en) 1991-02-22
DE69029198D1 (de) 1997-01-02
DK0489767T3 (da) 1996-12-09

Similar Documents

Publication Publication Date Title
ATE219077T1 (de) Endothelin antagoniste
DK0622361T3 (da) Heterocykliske forbindelser som bradykininantagonister
CO4340622A1 (es) Nuevos macrociclos bis-indolil maleimida
IE820421L (en) Imidazodiazepines
ATE25682T1 (de) Indol-3-carboxamid-derivate.
ES2053439T3 (es) Un procedimiento para la preparacion de un compuesto que tiene propiedades farmacologicas utiles.
ATE154021T1 (de) N-cyclohexyl benzamide derivate, ihre herstellungen und therapeutischen anwendungen
ES2095878T3 (es) Un antagonista a la cck.
ATE110365T1 (de) 2-alkyl-4-arylmethylaminochinoline, ihre verwendung und daraus hergestellte arzneimittel.
ATE56006T1 (de) Succinimide derivate, herstellung und anwendung.
NO922380D0 (no) Substituerte 4-fenyl-4-piperidinkarboksamider med baade lokal anestetisk og analgetisk effekt samt fremgangsmaater for deres fremstilling
DK484787A (da) Bis-dioxopiperazin-derivater
ES2072897T3 (es) Un metodo para producir y sintetizar una composicion farmaceutica y su uso.
ES2039363T3 (es) Procedimiento para la obtencion de pirrolo (1,2-a)(4,1) benzoxazepinas.
PT855398E (pt) Derivados sasquiterpeno tendo actividade antiviral
ES2014307B3 (es) Derivados de acilaminometil-1[1,2-a]quinoleinas, su preparacion y su aplicacion en terapeutica.
SE8602434D0 (sv) Kemiska foreningar
ES2077985T3 (es) Inhibidores de la acil-coa: colesterol-acil transferasa, a base de 5-bis-aminometilen-1,3-dioxano-4,6-diona n,n',n'-trisubstituida.
LV5820A4 (lv) ÚAlfa-(terc-butilaminometil)-3,4-dihlorbenzil¾-tioacetamids ta iegusanas panemiens un ta izmantosana
ECSP910725A (es) Procedimiento para preparar nuevos derivados de 4( 1h) quinolona

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 489767

Country of ref document: ES