ES2077985T3 - Inhibidores de la acil-coa: colesterol-acil transferasa, a base de 5-bis-aminometilen-1,3-dioxano-4,6-diona n,n',n'-trisubstituida. - Google Patents
Inhibidores de la acil-coa: colesterol-acil transferasa, a base de 5-bis-aminometilen-1,3-dioxano-4,6-diona n,n',n'-trisubstituida.Info
- Publication number
- ES2077985T3 ES2077985T3 ES92307981T ES92307981T ES2077985T3 ES 2077985 T3 ES2077985 T3 ES 2077985T3 ES 92307981 T ES92307981 T ES 92307981T ES 92307981 T ES92307981 T ES 92307981T ES 2077985 T3 ES2077985 T3 ES 2077985T3
- Authority
- ES
- Spain
- Prior art keywords
- acil
- trisubstituida
- aminometilen
- diona
- transferase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
UN COMPUESTO DE LA FORMULA: EN DONDE X, Y Y Z SON ,INDEPENDIENTEMENTE, HIDROGENO, HALOGENO, HIDROXI, NITRO, CIANO, CARBOXILO, TRIFLUORMETILO, FENILO, AMINO, ALQUILAMINO, DIALQUILAMINO, ALQUILO O ALCOXI; R1 ES ALQUILO, ALQUENILO, CICLOALQUILO, FENILO, BENZILO O BENZILO O FENILO SUSTITUIDO, R2 ES O UNA SAL FARMACEUTICAMENTE ACEPTABLE CONSIGUIENTE, SON INHIBIDORES ACAT.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/755,918 US5136039A (en) | 1991-09-06 | 1991-09-06 | N,N',N'-trisubstituted-5-bis-aminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase |
US07/847,127 US5177219A (en) | 1992-03-06 | 1992-03-06 | N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione compounds |
US07/879,494 US5164505A (en) | 1992-05-07 | 1992-05-07 | N-phenyl-N'-alkyl-N'-pyridylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-diones |
US07/914,886 US5187284A (en) | 1992-07-22 | 1992-07-22 | N-phenyl-N'-benzothienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2077985T3 true ES2077985T3 (es) | 1995-12-01 |
Family
ID=27505672
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92307981T Expired - Lifetime ES2077985T3 (es) | 1991-09-06 | 1992-09-03 | Inhibidores de la acil-coa: colesterol-acil transferasa, a base de 5-bis-aminometilen-1,3-dioxano-4,6-diona n,n',n'-trisubstituida. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0531119B1 (es) |
JP (1) | JPH05194502A (es) |
KR (1) | KR930006000A (es) |
AT (1) | ATE128978T1 (es) |
AU (1) | AU652852B2 (es) |
DE (1) | DE69205383T2 (es) |
DK (1) | DK0531119T3 (es) |
ES (1) | ES2077985T3 (es) |
GR (1) | GR3018392T3 (es) |
HU (1) | HUT65376A (es) |
MX (1) | MX9204939A (es) |
NZ (1) | NZ244210A (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017190714A1 (es) | 2016-05-04 | 2017-11-09 | Universidad De La Habana | Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0344425B1 (en) * | 1988-03-30 | 1993-12-08 | Warner-Lambert Company | N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents |
US5179216A (en) * | 1990-08-16 | 1993-01-12 | American Home Products Corporation | N,n', n'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-coa:cholesterol-acyl transferase |
-
1992
- 1992-08-27 MX MX9204939A patent/MX9204939A/es unknown
- 1992-09-03 DE DE69205383T patent/DE69205383T2/de not_active Expired - Fee Related
- 1992-09-03 ES ES92307981T patent/ES2077985T3/es not_active Expired - Lifetime
- 1992-09-03 JP JP4235808A patent/JPH05194502A/ja active Pending
- 1992-09-03 AT AT92307981T patent/ATE128978T1/de active
- 1992-09-03 DK DK92307981.8T patent/DK0531119T3/da active
- 1992-09-03 KR KR1019920015983A patent/KR930006000A/ko active IP Right Grant
- 1992-09-03 EP EP92307981A patent/EP0531119B1/en not_active Expired - Lifetime
- 1992-09-04 NZ NZ244210A patent/NZ244210A/en unknown
- 1992-09-04 HU HU9202849A patent/HUT65376A/hu unknown
- 1992-09-04 AU AU22126/92A patent/AU652852B2/en not_active Ceased
-
1995
- 1995-12-13 GR GR950403529T patent/GR3018392T3/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017190714A1 (es) | 2016-05-04 | 2017-11-09 | Universidad De La Habana | Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular |
Also Published As
Publication number | Publication date |
---|---|
MX9204939A (es) | 1993-03-01 |
NZ244210A (en) | 1994-08-26 |
EP0531119A1 (en) | 1993-03-10 |
DK0531119T3 (da) | 1995-11-27 |
GR3018392T3 (en) | 1996-03-31 |
ATE128978T1 (de) | 1995-10-15 |
JPH05194502A (ja) | 1993-08-03 |
HU9202849D0 (en) | 1992-11-30 |
AU2212692A (en) | 1993-03-11 |
EP0531119B1 (en) | 1995-10-11 |
AU652852B2 (en) | 1994-09-08 |
HUT65376A (en) | 1994-05-02 |
DE69205383T2 (de) | 1996-03-21 |
DE69205383D1 (de) | 1995-11-16 |
KR930006000A (ko) | 1993-04-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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