DE69205383T2 - N,N',N'-trisubstituierte 5-Bisaminomethylen-1,3-Dioxan-4,6-Dione als Acyl-CoA: Cholesterol-Acyltransferasehemmer. - Google Patents

N,N',N'-trisubstituierte 5-Bisaminomethylen-1,3-Dioxan-4,6-Dione als Acyl-CoA: Cholesterol-Acyltransferasehemmer.

Info

Publication number
DE69205383T2
DE69205383T2 DE69205383T DE69205383T DE69205383T2 DE 69205383 T2 DE69205383 T2 DE 69205383T2 DE 69205383 T DE69205383 T DE 69205383T DE 69205383 T DE69205383 T DE 69205383T DE 69205383 T2 DE69205383 T2 DE 69205383T2
Authority
DE
Germany
Prior art keywords
acyl
bisaminomethylene
diones
trisubstituted
coa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69205383T
Other languages
English (en)
Other versions
DE69205383D1 (de
Inventor
William Floyd Fobare
Donald Peter Strike
Patrick Michael Andrae
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/755,918 external-priority patent/US5136039A/en
Priority claimed from US07/847,127 external-priority patent/US5177219A/en
Priority claimed from US07/879,494 external-priority patent/US5164505A/en
Priority claimed from US07/914,886 external-priority patent/US5187284A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of DE69205383D1 publication Critical patent/DE69205383D1/de
Publication of DE69205383T2 publication Critical patent/DE69205383T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DE69205383T 1991-09-06 1992-09-03 N,N',N'-trisubstituierte 5-Bisaminomethylen-1,3-Dioxan-4,6-Dione als Acyl-CoA: Cholesterol-Acyltransferasehemmer. Expired - Fee Related DE69205383T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/755,918 US5136039A (en) 1991-09-06 1991-09-06 N,N',N'-trisubstituted-5-bis-aminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA:cholesterol-acyl transferase
US07/847,127 US5177219A (en) 1992-03-06 1992-03-06 N-phenyl-N'-thienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione compounds
US07/879,494 US5164505A (en) 1992-05-07 1992-05-07 N-phenyl-N'-alkyl-N'-pyridylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-diones
US07/914,886 US5187284A (en) 1992-07-22 1992-07-22 N-phenyl-N'-benzothienylmethyl-bis-diamino-5-methylene-1,3-dioxane-4,6-dione derivatives

Publications (2)

Publication Number Publication Date
DE69205383D1 DE69205383D1 (de) 1995-11-16
DE69205383T2 true DE69205383T2 (de) 1996-03-21

Family

ID=27505672

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69205383T Expired - Fee Related DE69205383T2 (de) 1991-09-06 1992-09-03 N,N',N'-trisubstituierte 5-Bisaminomethylen-1,3-Dioxan-4,6-Dione als Acyl-CoA: Cholesterol-Acyltransferasehemmer.

Country Status (12)

Country Link
EP (1) EP0531119B1 (de)
JP (1) JPH05194502A (de)
KR (1) KR930006000A (de)
AT (1) ATE128978T1 (de)
AU (1) AU652852B2 (de)
DE (1) DE69205383T2 (de)
DK (1) DK0531119T3 (de)
ES (1) ES2077985T3 (de)
GR (1) GR3018392T3 (de)
HU (1) HUT65376A (de)
MX (1) MX9204939A (de)
NZ (1) NZ244210A (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CU24576B1 (es) 2016-05-04 2022-02-04 Centro De Investig Y Desarrollo De Medicamentos Cidem Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0678298B2 (ja) * 1988-03-30 1994-10-05 ワーナー‐ランバート・コンパニー Ｎ‐〔〔（２，６‐ジ置換）フエニル〕‐ｎ′‐アリールアルキル〕尿素
US5179216A (en) * 1990-08-16 1993-01-12 American Home Products Corporation N,n', n'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-coa:cholesterol-acyl transferase

Also Published As

Publication number Publication date
EP0531119A1 (de) 1993-03-10
HU9202849D0 (en) 1992-11-30
HUT65376A (en) 1994-05-02
AU652852B2 (en) 1994-09-08
DE69205383D1 (de) 1995-11-16
ATE128978T1 (de) 1995-10-15
NZ244210A (en) 1994-08-26
KR930006000A (ko) 1993-04-20
DK0531119T3 (da) 1995-11-27
MX9204939A (es) 1993-03-01
ES2077985T3 (es) 1995-12-01
AU2212692A (en) 1993-03-11
EP0531119B1 (de) 1995-10-11
JPH05194502A (ja) 1993-08-03
GR3018392T3 (en) 1996-03-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee