ES2039363T3 - Procedimiento para la obtencion de pirrolo (1,2-a)(4,1) benzoxazepinas. - Google Patents
Procedimiento para la obtencion de pirrolo (1,2-a)(4,1) benzoxazepinas.Info
- Publication number
- ES2039363T3 ES2039363T3 ES87100598T ES87100598T ES2039363T3 ES 2039363 T3 ES2039363 T3 ES 2039363T3 ES 87100598 T ES87100598 T ES 87100598T ES 87100598 T ES87100598 T ES 87100598T ES 2039363 T3 ES2039363 T3 ES 2039363T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- image
- represents hydrogen
- halogen
- benzoxazepinas
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
LA INVENCION SE REFIERE A NUEVOS COMPUESTOS DE ACCION ANTIDIARREICA Y EFECTO ELIMINADOR DE SECRECION GASTROINTESTINAL DE LA FORMULA GENERAL (I) DONDE N ES UN NUMERO ENTERO 1,2,3 O 4, R1 SIGNIFICA HIDROGENO, ALQUILO INFERIOR, HALOGENO, TRIFLUOROMETILO, HIDROXI O ALCOXI INFERIOR; R2 ES HIDROGENO O ALQUILO INFERIOR; R3 ES HIDROGENO ALQUILO INFERIOR O HALOGENO; R4 ES AMINO, ALQUILAMINO INFERIOR, DIALQUILAMINO INFERIOR, MORFOLINO, N-ALQUILO INFERIOR O N-ARILPIPERAZINO, PIRROLIDINO, PIPERIDINO O PIPERIDINO SUSTITUIDO SELECCIONADO DE (II) Y (III) DONDE R5 ES HIDROGENO, HALOGENO O ALQUILO INFERIOR; Y SALES EN ESPECIAL SALES FARMACEUTICAS DE TODOS LOS COMPUESTOS. PUEDEN P.E. OBTENERSE POR CONDENSACION DE UNA AMINA DE LA FORMULA (III) DONDE R4 TIENE EL SIGNIFICADO INDICADO ARRIBA Y H ESTA UNIDO AL ATOMO DE NITROGENO DEL GRUPO R4, CON UN COMPUESTO DE LA FORMULA IV.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/821,110 US4758559A (en) | 1986-01-21 | 1986-01-21 | Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2039363T3 true ES2039363T3 (es) | 1995-04-01 |
Family
ID=25232538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87100598T Expired - Lifetime ES2039363T3 (es) | 1986-01-21 | 1987-01-19 | Procedimiento para la obtencion de pirrolo (1,2-a)(4,1) benzoxazepinas. |
Country Status (25)
Country | Link |
---|---|
US (1) | US4758559A (es) |
EP (1) | EP0233483B1 (es) |
JP (2) | JPH0780888B2 (es) |
KR (1) | KR900004148B1 (es) |
AT (1) | ATE62244T1 (es) |
AU (1) | AU598510B2 (es) |
CA (1) | CA1273335A (es) |
CY (1) | CY1749A (es) |
DD (1) | DD257430A5 (es) |
DE (1) | DE3768978D1 (es) |
DK (1) | DK169239B1 (es) |
ES (1) | ES2039363T3 (es) |
FI (1) | FI86636C (es) |
GR (1) | GR3001737T3 (es) |
HK (1) | HK24194A (es) |
HU (1) | HU198061B (es) |
IE (1) | IE59653B1 (es) |
IL (1) | IL81302A (es) |
MA (1) | MA20857A1 (es) |
MY (1) | MY100914A (es) |
PH (1) | PH25148A (es) |
PT (1) | PT84136B (es) |
TN (1) | TNSN87003A1 (es) |
ZA (1) | ZA87389B (es) |
ZW (1) | ZW787A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE235474T1 (de) * | 1992-04-20 | 2003-04-15 | Takeda Chemical Industries Ltd | 4,1-benzoxazepinderivate als squalen-synthetase inhibitoren und ihre verwendung zur behandlung von hypercholesterämie und als fungizide |
US5452434A (en) * | 1992-07-14 | 1995-09-19 | Advanced Micro Devices, Inc. | Clock control for power savings in high performance central processing units |
USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
US5439524A (en) * | 1993-04-05 | 1995-08-08 | Vlsi Technology, Inc. | Plasma processing apparatus |
US5698518A (en) * | 1994-03-30 | 1997-12-16 | Oklahoma Medical Research Foundation | Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists |
US5624902A (en) * | 1995-06-07 | 1997-04-29 | Torrey Pines Institute For Molecular Studies | Peptide inhibitors of calmodulin |
US6423329B1 (en) | 1999-02-12 | 2002-07-23 | The Procter & Gamble Company | Skin sanitizing compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4029672A (en) * | 1976-02-26 | 1977-06-14 | American Hoechst Corporation | Aminoalkylpyrrolobenzoxazalkanes |
US4045448A (en) * | 1976-02-26 | 1977-08-30 | American Hoechst Corporation | Pyrrolo[2,1-c][1,4]benzoxazepine and benzoxazocine derivatives |
US4053599A (en) * | 1976-02-26 | 1977-10-11 | American Hoechst Corporation | Piperazionalkylpyrrolobenzoxazalkanes |
US4169095A (en) * | 1977-01-19 | 1979-09-25 | American Hoechst Corporation | Process for preparing aminoalkylpyrrolobenzoxazalkanes |
US4608374A (en) * | 1983-11-07 | 1986-08-26 | Hoechst-Roussel Pharmaceuticals Inc. | 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents |
-
1986
- 1986-01-21 US US06/821,110 patent/US4758559A/en not_active Expired - Lifetime
-
1987
- 1987-01-05 MY MYPI87000013A patent/MY100914A/en unknown
- 1987-01-14 PH PH34722A patent/PH25148A/en unknown
- 1987-01-19 EP EP87100598A patent/EP0233483B1/de not_active Expired - Lifetime
- 1987-01-19 DE DE8787100598T patent/DE3768978D1/de not_active Expired - Lifetime
- 1987-01-19 DD DD87299332A patent/DD257430A5/de unknown
- 1987-01-19 PT PT84136A patent/PT84136B/pt unknown
- 1987-01-19 AT AT87100598T patent/ATE62244T1/de not_active IP Right Cessation
- 1987-01-19 ES ES87100598T patent/ES2039363T3/es not_active Expired - Lifetime
- 1987-01-19 IL IL81302A patent/IL81302A/xx not_active IP Right Cessation
- 1987-01-19 FI FI870207A patent/FI86636C/fi not_active IP Right Cessation
- 1987-01-19 CA CA000527583A patent/CA1273335A/en not_active Expired - Lifetime
- 1987-01-20 TN TNTNSN87003A patent/TNSN87003A1/fr unknown
- 1987-01-20 AU AU67813/87A patent/AU598510B2/en not_active Ceased
- 1987-01-20 ZA ZA87389A patent/ZA87389B/xx unknown
- 1987-01-20 IE IE13987A patent/IE59653B1/en not_active IP Right Cessation
- 1987-01-20 DK DK029587A patent/DK169239B1/da not_active IP Right Cessation
- 1987-01-20 JP JP62009181A patent/JPH0780888B2/ja not_active Expired - Fee Related
- 1987-01-20 ZW ZW7/87A patent/ZW787A1/xx unknown
- 1987-01-20 MA MA21090A patent/MA20857A1/fr unknown
- 1987-01-20 HU HU87152A patent/HU198061B/hu not_active IP Right Cessation
- 1987-01-21 KR KR1019870000454A patent/KR900004148B1/ko not_active IP Right Cessation
-
1991
- 1991-04-04 GR GR91400317T patent/GR3001737T3/el unknown
-
1993
- 1993-12-22 JP JP5324407A patent/JPH0826028B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-17 HK HK241/94A patent/HK24194A/xx not_active IP Right Cessation
- 1994-06-03 CY CY174994A patent/CY1749A/xx unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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