TNSN87003A1 - Pyrrolo (1,2-a)(4,1) benzoxazepines, procedes pour leur preparation - Google Patents
Pyrrolo (1,2-a)(4,1) benzoxazepines, procedes pour leur preparationInfo
- Publication number
- TNSN87003A1 TNSN87003A1 TNTNSN87003A TNSN87003A TNSN87003A1 TN SN87003 A1 TNSN87003 A1 TN SN87003A1 TN TNSN87003 A TNTNSN87003 A TN TNSN87003A TN SN87003 A TNSN87003 A TN SN87003A TN SN87003 A1 TNSN87003 A1 TN SN87003A1
- Authority
- TN
- Tunisia
- Prior art keywords
- lower alkyl
- image
- represents hydrogen
- halogen
- benzoxazepines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
L INVENTION CONCERNE DE NOUVEAUX COMPOSES POSSEDANT DES ACTIVITES D'INHIBITION DES SECRETIONS GASTRO-INTESTINALES ET ANTI- DIARRHEIQUES, QUI REPONDENT A LA FORMULE GENERALE I, DANS LAQUELLE N EST EGAL A 1, 2, 3 OU 4 ; R1 REPRESENTE H, UN GROUPE ALKYLE INFERIEUR, UN HALOGENE, UN GROUPE TRIFLUOROMETHYLE, HYDROXY OU ALCOXY INFERIEUR ; R2 REPRESENTE H OU UN GROUPE ALKYLE INFERIEUR ; R3 REPRESENTE H, UN GROUPE ALKYLE INFERIEUR OU UN HALOGENE ; R4 REPRESENTE UN GROUPE AMINO, ALKYLAMINO INFERIEUR, DI-(ALKYLE INFERIEUR)-AMINO, MORPHOLINO, N-ALKYLE INFERIEUR OU N-ARYLPIPERAZINO, PYRROLIDINO, PIPERIDINO, PIPERIDINO SUBSTITUE CHOISI PARMI , ET DANS LESQUELS R5 = H, UN HALOGENE OU UN GROUPE ALKYLE INFERIEUR ; ET LEURS SELS, EN PARTICULIER LEURS SELS ACCEPTABLES POUR L'USAGE PHARMACEUTIQUE. ON PEUT LES PREPARER PAR EXEMPLE EN CONDENSANT UNE AMINE DE FORMULE III R4-H, DANS LAQUELLE R4 A LES SIGNIFICATIONS INDIQUEES CI-DESSUS ET H EST FIXE SUR L'ATOME D'AZOTE DU GROUPE R4, AVEC UN COMPOSE DE FORMULE IV, DANS LAQUELLE N, R1, R2 ET R3 ONT LES SIGNIFICATIONS INDIQUEES EN REFERENCE A LA FORMULE I, ET X REPRESENTE UN GROUPE HYDROXY ESTERIFIE REACTIF
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/821,110 US4758559A (en) | 1986-01-21 | 1986-01-21 | Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN87003A1 true TNSN87003A1 (fr) | 1990-01-01 |
Family
ID=25232538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN87003A TNSN87003A1 (fr) | 1986-01-21 | 1987-01-20 | Pyrrolo (1,2-a)(4,1) benzoxazepines, procedes pour leur preparation |
Country Status (25)
Country | Link |
---|---|
US (1) | US4758559A (fr) |
EP (1) | EP0233483B1 (fr) |
JP (2) | JPH0780888B2 (fr) |
KR (1) | KR900004148B1 (fr) |
AT (1) | ATE62244T1 (fr) |
AU (1) | AU598510B2 (fr) |
CA (1) | CA1273335A (fr) |
CY (1) | CY1749A (fr) |
DD (1) | DD257430A5 (fr) |
DE (1) | DE3768978D1 (fr) |
DK (1) | DK169239B1 (fr) |
ES (1) | ES2039363T3 (fr) |
FI (1) | FI86636C (fr) |
GR (1) | GR3001737T3 (fr) |
HK (1) | HK24194A (fr) |
HU (1) | HU198061B (fr) |
IE (1) | IE59653B1 (fr) |
IL (1) | IL81302A (fr) |
MA (1) | MA20857A1 (fr) |
MY (1) | MY100914A (fr) |
PH (1) | PH25148A (fr) |
PT (1) | PT84136B (fr) |
TN (1) | TNSN87003A1 (fr) |
ZA (1) | ZA87389B (fr) |
ZW (1) | ZW787A1 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG82630A1 (en) * | 1992-04-20 | 2001-08-21 | Takeda Chemical Industries Ltd | 4,1-benzoxazepin derivatives and their use |
US5452434A (en) * | 1992-07-14 | 1995-09-19 | Advanced Micro Devices, Inc. | Clock control for power savings in high performance central processing units |
US5321012A (en) * | 1993-01-28 | 1994-06-14 | Virginia Commonwealth University Medical College | Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance |
USRE39300E1 (en) | 1993-01-28 | 2006-09-19 | Virginia Commonwealth University Medical College Of Virginia | Inhibiting the development of tolerance to and/or dependence on an addictive substance |
US5439524A (en) * | 1993-04-05 | 1995-08-08 | Vlsi Technology, Inc. | Plasma processing apparatus |
US5698518A (en) * | 1994-03-30 | 1997-12-16 | Oklahoma Medical Research Foundation | Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists |
US5624902A (en) * | 1995-06-07 | 1997-04-29 | Torrey Pines Institute For Molecular Studies | Peptide inhibitors of calmodulin |
US6423329B1 (en) | 1999-02-12 | 2002-07-23 | The Procter & Gamble Company | Skin sanitizing compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4053599A (en) * | 1976-02-26 | 1977-10-11 | American Hoechst Corporation | Piperazionalkylpyrrolobenzoxazalkanes |
US4045448A (en) * | 1976-02-26 | 1977-08-30 | American Hoechst Corporation | Pyrrolo[2,1-c][1,4]benzoxazepine and benzoxazocine derivatives |
US4029672A (en) * | 1976-02-26 | 1977-06-14 | American Hoechst Corporation | Aminoalkylpyrrolobenzoxazalkanes |
US4169095A (en) * | 1977-01-19 | 1979-09-25 | American Hoechst Corporation | Process for preparing aminoalkylpyrrolobenzoxazalkanes |
US4608374A (en) * | 1983-11-07 | 1986-08-26 | Hoechst-Roussel Pharmaceuticals Inc. | 11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents |
-
1986
- 1986-01-21 US US06/821,110 patent/US4758559A/en not_active Expired - Lifetime
-
1987
- 1987-01-05 MY MYPI87000013A patent/MY100914A/en unknown
- 1987-01-14 PH PH34722A patent/PH25148A/en unknown
- 1987-01-19 AT AT87100598T patent/ATE62244T1/de not_active IP Right Cessation
- 1987-01-19 PT PT84136A patent/PT84136B/pt unknown
- 1987-01-19 ES ES87100598T patent/ES2039363T3/es not_active Expired - Lifetime
- 1987-01-19 DD DD87299332A patent/DD257430A5/de unknown
- 1987-01-19 IL IL81302A patent/IL81302A/xx not_active IP Right Cessation
- 1987-01-19 EP EP87100598A patent/EP0233483B1/fr not_active Expired - Lifetime
- 1987-01-19 CA CA000527583A patent/CA1273335A/fr not_active Expired - Lifetime
- 1987-01-19 DE DE8787100598T patent/DE3768978D1/de not_active Expired - Lifetime
- 1987-01-19 FI FI870207A patent/FI86636C/fi not_active IP Right Cessation
- 1987-01-20 MA MA21090A patent/MA20857A1/fr unknown
- 1987-01-20 TN TNTNSN87003A patent/TNSN87003A1/fr unknown
- 1987-01-20 ZW ZW7/87A patent/ZW787A1/xx unknown
- 1987-01-20 IE IE13987A patent/IE59653B1/en not_active IP Right Cessation
- 1987-01-20 DK DK029587A patent/DK169239B1/da not_active IP Right Cessation
- 1987-01-20 HU HU87152A patent/HU198061B/hu not_active IP Right Cessation
- 1987-01-20 ZA ZA87389A patent/ZA87389B/xx unknown
- 1987-01-20 AU AU67813/87A patent/AU598510B2/en not_active Ceased
- 1987-01-20 JP JP62009181A patent/JPH0780888B2/ja not_active Expired - Fee Related
- 1987-01-21 KR KR1019870000454A patent/KR900004148B1/ko not_active IP Right Cessation
-
1991
- 1991-04-04 GR GR91400317T patent/GR3001737T3/el unknown
-
1993
- 1993-12-22 JP JP5324407A patent/JPH0826028B2/ja not_active Expired - Lifetime
-
1994
- 1994-03-17 HK HK241/94A patent/HK24194A/xx not_active IP Right Cessation
- 1994-06-03 CY CY174994A patent/CY1749A/xx unknown
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