ES2094130T3 - Procedimiento para la produccion de una 4,6-bis(difluorometoxi)-2-alquiltiopirimidina. - Google Patents

Procedimiento para la produccion de una 4,6-bis(difluorometoxi)-2-alquiltiopirimidina.

Info

Publication number
ES2094130T3
ES2094130T3 ES90114191T ES90114191T ES2094130T3 ES 2094130 T3 ES2094130 T3 ES 2094130T3 ES 90114191 T ES90114191 T ES 90114191T ES 90114191 T ES90114191 T ES 90114191T ES 2094130 T3 ES2094130 T3 ES 2094130T3
Authority
ES
Spain
Prior art keywords
bis
base
monochlorodifluoromethane
alkyltiopyrimidine
difluorometoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90114191T
Other languages
English (en)
Inventor
Sumio Yoshino
Kazuyuki Watanabe
Mikio Akazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Kawaguchi Chemical Industry Co Ltd
AGC Inc
Original Assignee
Ciba Geigy AG
Asahi Glass Co Ltd
Kawaguchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy AG, Asahi Glass Co Ltd, Kawaguchi Chemical Industry Co Ltd filed Critical Ciba Geigy AG
Application granted granted Critical
Publication of ES2094130T3 publication Critical patent/ES2094130T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UN PROCESO PARA PRODUCIR UNA 4,6-BIS-(DIFLUOROMETOXI)-2-ALQUILTIOPIRIMIDINA , QUE INCLUYE LA REACCION DE UN ACIDO 2-ALQUILTIOBARBITURICO Y MONOCLORODIFLUOROMETANO EN PRESENCIA DE UNA BASE EN UN SOLVENTE INERTE, EN DONDE, PARA UNA PRIMERA REACCION, DESPUES DE CARGAR UNA PARTE DE LA BASE, EL RESTO DE LA BASE Y EL MONOCLORODIFLUOROMETANO SE INTRODUCE SIMULTANEAMENTE PARA OBTENER UNA MEZCLA DE UNA 4-DIFLUOROMETOXI-6-HIDROXI -2-ALQUILTIOPIRIMIDINA Y UNA 4,6-BIS(DIFLUOROMETOXI)-2-ALQUILTIOPIRIMIDINA , Y LUEGO, DURANTE UNA SEGUNDA REACCION, PARA ESTA MEZCLA, LA BASE Y EL MONOCLORODIFLUOROMETANO SE INTRODUCEN DE NUEVO SIMULTANEAMENTE, O SE CARGA PRIMERO LA BASE, Y DESPUES SE INTRODUCE EL MONOCLORODIFLUOROMETANO.
ES90114191T 1989-01-24 1990-07-24 Procedimiento para la produccion de una 4,6-bis(difluorometoxi)-2-alquiltiopirimidina. Expired - Lifetime ES2094130T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1013307A JPH0662588B2 (ja) 1989-01-24 1989-01-24 ４，６―ビス（ジフルオロメトキシ）―２―メチルチオピリミジンの製造法
EP90114191A EP0468069B1 (en) 1989-01-24 1990-07-24 Process for producing a 4,6-bis(difluoromethoxy)-2-alkylthiopyrimidine

Publications (1)

Publication Number Publication Date
ES2094130T3 true ES2094130T3 (es) 1997-01-16

Family

ID=40139217

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90114191T Expired - Lifetime ES2094130T3 (es) 1989-01-24 1990-07-24 Procedimiento para la produccion de una 4,6-bis(difluorometoxi)-2-alquiltiopirimidina.

Country Status (6)

Country Link
US (1) US5071982A (es)
EP (1) EP0468069B1 (es)
JP (1) JPH0662588B2 (es)
AT (1) ATE143660T1 (es)
DE (1) DE69028774T2 (es)
ES (1) ES2094130T3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2208734C (en) * 1996-07-24 2006-05-30 Lonza Ag Process for preparing 4,6-bis(difluoro-methoxy)pyrimidine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4542216A (en) * 1984-03-27 1985-09-17 Ciba Geigy Corporation Process for producing fluoroalkoxyaminopyrimidines
US4692524A (en) * 1986-05-02 1987-09-08 Ciba-Geigy Corporation Process for the preparation of pyrimidine derivatives
US4900827A (en) * 1988-12-22 1990-02-13 Ciba-Geigy Corporation Process for the preparation of pyrimidine derivatives

Also Published As

Publication number Publication date
JPH0662588B2 (ja) 1994-08-17
US5071982A (en) 1991-12-10
ATE143660T1 (de) 1996-10-15
EP0468069A1 (en) 1992-01-29
JPH02196773A (ja) 1990-08-03
DE69028774T2 (de) 1997-02-13
EP0468069B1 (en) 1996-10-02
DE69028774D1 (de) 1996-11-07

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