HUT48263A - Continuous process for producing phosphono-phosphate
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Continuous process for producing phosphono-phosphate
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Publication number
HUT48263A
HUT48263AHU523887AHU523887AHUT48263AHU T48263 AHUT48263 AHU T48263AHU 523887 AHU523887 AHU 523887AHU 523887 AHU523887 AHU 523887AHU T48263 AHUT48263 AHU T48263A
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Application filed by Biogal GyogyszergyarfiledCriticalBiogal Gyogyszergyar
Priority to HU523887ApriorityCriticalpatent/HU198213B/en
Publication of HUT48263ApublicationCriticalpatent/HUT48263A/en
Publication of HU198213BpublicationCriticalpatent/HU198213B/en
Phosphonium-phosphate derivs. of formula (I) are prepd., opt. in a continuous process, as follows: R = 1-4C and X = halogenide. In case of more than one halogenide they may be same or dissimilar. Benzoyl-phosphonate (II) is prepd. by adding a tri:alkyl-phosphate (IV) to benzoyl-halogenide (V) in 1:1 molar proportion. Benzoyl-phosphonate (II) pred. above and di:alkyl-phosphonate (III) yields (I). This reaction proceeds in the presence of a base pref. di:n-butyl-amine and in an inert solvent pref. toluene. The reaction is carried out directly or following the removal by distn. of alkyl-halogenide.
HU523887A1987-11-241987-11-24Continuous process for producing phosphono-phosphate derivatives
HU198213B
(en)
Stereoselective process for preparing .beta.-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonate intermediates