ES2092481T3 - Uso de derivados de poliamina para la potencializacion de la inmunidad celular. - Google Patents

Uso de derivados de poliamina para la potencializacion de la inmunidad celular.

Info

Publication number
ES2092481T3
ES2092481T3 ES90109847T ES90109847T ES2092481T3 ES 2092481 T3 ES2092481 T3 ES 2092481T3 ES 90109847 T ES90109847 T ES 90109847T ES 90109847 T ES90109847 T ES 90109847T ES 2092481 T3 ES2092481 T3 ES 2092481T3
Authority
ES
Spain
Prior art keywords
potentialization
cellular immunity
polyamine derivatives
saturated
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90109847T
Other languages
English (en)
Inventor
Terry L Bowlin
Nellikunja Prakash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2092481T3 publication Critical patent/ES2092481T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

EL INVENTO SE REFIRE AL USO DE UN COMPUESTO DE LA FORMULA: RHN-Z-NH- (CH2)M-NH-Z-NHR O LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO EN DONDE M ES UN ENTERO ENTRE 3 Y 12, Z ES UNA MOLECULA DE ALQUILENO C2-C6 SATURADA, DE CONFIGURACION DE CADENA RECTA O RAMIFICADA, CADA GRUPO R ES INDEPENDIENTEMENTE H, UN HIDROCARBIL C1-C6 SATURADO O INSATURADO, O BIEN -(CH2)X-(AR)-X EN DONDE X ES H, ALCOXIDO C1-C6, HALOGENO, ALQUIL C1-C4, O -S(0)XR1, X ES UN ENTERO ENTRE 0,1 O 2, Y R1 ES ALQUIL C1-C6. EL COMPUESTO ES UTIL PARA LA POTENCIACION DE LA INMUNIDAD CELULAR.
ES90109847T 1989-05-23 1990-05-23 Uso de derivados de poliamina para la potencializacion de la inmunidad celular. Expired - Lifetime ES2092481T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35573689A 1989-05-23 1989-05-23

Publications (1)

Publication Number Publication Date
ES2092481T3 true ES2092481T3 (es) 1996-12-01

Family

ID=23398633

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90109847T Expired - Lifetime ES2092481T3 (es) 1989-05-23 1990-05-23 Uso de derivados de poliamina para la potencializacion de la inmunidad celular.

Country Status (11)

Country Link
EP (1) EP0399519B1 (es)
JP (1) JP2835773B2 (es)
KR (1) KR900017577A (es)
AT (1) ATE141048T1 (es)
AU (1) AU628174B2 (es)
DE (1) DE69028006T2 (es)
DK (1) DK0399519T3 (es)
ES (1) ES2092481T3 (es)
GR (1) GR3021500T3 (es)
IE (1) IE81081B1 (es)
ZA (1) ZA903804B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561136A (en) * 1990-12-13 1996-10-01 Merrell Pharmaceuticals Inc. Method of treating cancer by conjunctive therapy with N,N'-bis[ethylamino)propyl]-1,7-heptanediamine and a cytotoxic agent
ZA919695B (en) * 1990-12-13 1992-09-30 Merrell Dow Pharma Method of treating cancer by conjunctive therapy with n,n'-bis(3-(ethylamino)propyl)-1,7-heptanediamine and a cytotoxic agent
GB9220921D0 (en) * 1992-10-05 1992-11-18 Merrell Dow Pharma Polyamine derivatives as anticytomegaloviral agents
JPH09505058A (ja) * 1993-11-15 1997-05-20 ベイカー・メディカル・リサーチ・インスティテュート 心機能不全の治療方法およびそのために有用な医薬組成物
FR2724379B1 (fr) * 1994-09-13 1996-11-29 Fournier Sca Lab Procede de fabrication de polyamines qui sont des homologues structuraux de la spermidine.
US5516807A (en) * 1994-10-25 1996-05-14 Warner-Lambert Company Method for treating vascular proliferative disorders following balloon angioplasty
US7087648B1 (en) 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US8198334B2 (en) 1997-10-27 2012-06-12 Pathologica Llc Methods for modulating macrophage proliferation in ocular disease using polyamine analogs
AU2003231670B2 (en) * 1997-10-27 2006-06-08 Slil Biomedical Corporation Methods for modulating macrophage proliferation using polyamine analogs
AU2001251735B2 (en) * 2000-03-24 2005-09-01 Mediquest Therapeutics, Inc. Polyamine analogues as cytotoxic agents
US6919483B2 (en) * 2003-05-23 2005-07-19 Mediquest Therapeutics, Inc. Immunomodulation with novel pharmaceutical compositions
CA3089388A1 (en) * 2018-01-30 2019-08-08 Sun Biopharma, Inc. Methods for producing (6s,15s)-3,8,13,18-tetraazaicosane-6,15-diol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5998015A (ja) * 1982-11-27 1984-06-06 Microbial Chem Res Found 免疫賦活剤
NZ212053A (en) * 1984-05-17 1988-02-29 Merrell Dow Pharma Polyamine containing pharmaceutical compositions for treating neoplasms
JPS62263127A (ja) * 1986-05-06 1987-11-16 メレルダウフア−マス−テイカルズ　インコ−ポレ−テツド 自己由来のｌａｋ細胞、インタ−ロイキン−２、及びオルニチンデカルボキシラ−ゼ阻害剤による腫瘍の処置
NZ223340A (en) * 1987-02-03 1991-03-26 Merrell Dow Pharma Polyamine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
DK0399519T3 (da) 1996-09-02
EP0399519A3 (en) 1991-12-04
GR3021500T3 (en) 1997-01-31
JP2835773B2 (ja) 1998-12-14
EP0399519A2 (en) 1990-11-28
DE69028006T2 (de) 1997-03-20
DE69028006D1 (de) 1996-09-12
AU5517190A (en) 1990-11-29
JPH035420A (ja) 1991-01-11
ATE141048T1 (de) 1996-08-15
AU628174B2 (en) 1992-09-10
KR900017577A (ko) 1990-12-19
EP0399519B1 (en) 1996-08-07
IE901845L (en) 1990-11-23
IE81081B1 (en) 2000-02-23
ZA903804B (en) 1991-03-27

Similar Documents

Publication Publication Date Title
ES2092481T3 (es) Uso de derivados de poliamina para la potencializacion de la inmunidad celular.
GR3001889T3 (en) Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same
ES2095976T3 (es) Compuestos de pirazolopiridina y procedimiento para su preparacion.
ES2063186T3 (es) Derivados ftalinida, composicion farmaceutica y uso.
BR9503536A (pt) Composto processo para sua preparação seu uso e composição farmacêutica
NZ229347A (en) Substituted cephalosporin derivatives; pharmaceutical compositions, preparatory processes and intermediates
ES2037095T3 (es) Un procedimiento para preparar una composicion farmaceutica.
IL85822A (en) 7-alkanesulphonoamido-1,2,4,5-tetrahydro-3h-3-benzazepine derivatives,their preparation and pharmaceutical compositions containing them
ES2045067T3 (es) Procedimiento para preparar nuevos compuestos de tiazol.
KR900001715A (ko) Bu-3608 유도체
ES556552A0 (es) Un procedimiento para preparar un derivado de 1,5-benzotiazepina
LV10923A (lv) Penciklovira atvasinajumi hepatita-B infekciju arstesanai
IL95762A0 (en) Benzanilides,their preparation and pharmaceutical compositions containing the same
ES533282A0 (es) Un procedimiento para la preparacion de nuevos derivados de 1,5-benzotiazepina.
IT1227049B (it) Impiego di derivati adenosinici per la preparazione di composizioni farmaceutiche aventi attivita' immunostimolante.
DK168284D0 (da) Troponderivater
GB2190587B (en) Prophylactic and curing composition for arteriosclerosis
DK0682023T3 (da) Imidazopyridinderivater og fremgangsmåde til fremstilling deraf

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 399519

Country of ref document: ES