ES2092067T3 - Procedimiento de purificacion de una proteina altamente glicosilada. - Google Patents

Procedimiento de purificacion de una proteina altamente glicosilada.

Info

Publication number
ES2092067T3
ES2092067T3 ES92400381T ES92400381T ES2092067T3 ES 2092067 T3 ES2092067 T3 ES 2092067T3 ES 92400381 T ES92400381 T ES 92400381T ES 92400381 T ES92400381 T ES 92400381T ES 2092067 T3 ES2092067 T3 ES 2092067T3
Authority
ES
Spain
Prior art keywords
protein
purification procedure
highly
highly glycosilated
glycosilated protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92400381T
Other languages
English (en)
Inventor
Hanno Kolbe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Application granted granted Critical
Publication of ES2092067T3 publication Critical patent/ES2092067T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/30Extraction; Separation; Purification by precipitation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification
    • Y10S435/816Enzyme separation or purification by solubility

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

LA INVENCION PROPONE UN PROCESO PARA PURIFICAR UNA PROTEINA FUERTEMENTE GLICOSILADA A PARTIR DE UNA PREPARACION BRUTA QUE COMPRENDE EL HECHO (I) DE AÑADIR A DICHA PREPARACION UN ION METALICA BIVALENTE EN CANTIDAD SUFICIENTE DE MANERA A FORMAR UNA MEZCLA QUE PRECIPITA Y (II), TRAS LA PRECIPITACION, DE RECOGER DICHA PROTEINA EN EL SUPERNADANTE DE LA MEZCLA.
ES92400381T 1991-02-15 1992-02-13 Procedimiento de purificacion de una proteina altamente glicosilada. Expired - Lifetime ES2092067T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9101830A FR2672895B1 (fr) 1991-02-15 1991-02-15 Procede de purification d'une proteine fortement glycosylee.

Publications (1)

Publication Number Publication Date
ES2092067T3 true ES2092067T3 (es) 1996-11-16

Family

ID=9409766

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92400381T Expired - Lifetime ES2092067T3 (es) 1991-02-15 1992-02-13 Procedimiento de purificacion de una proteina altamente glicosilada.

Country Status (9)

Country Link
US (1) US5276141A (es)
EP (1) EP0499541B1 (es)
JP (1) JP3376430B2 (es)
AT (1) ATE141283T1 (es)
CA (1) CA2061167C (es)
DE (1) DE69212660T2 (es)
DK (1) DK0499541T3 (es)
ES (1) ES2092067T3 (es)
FR (1) FR2672895B1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284874B1 (en) * 1994-06-17 2001-09-04 Alpha Therapeutic Corporation Process for separating α1-proteinase inhibitor from cohn fraction IV1 and IV4 paste
US5760189A (en) * 1995-06-02 1998-06-02 Genetics Institute, Inc. Protein recovery & purification methods
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
DK1189935T3 (da) * 1999-06-25 2009-02-09 Wyeth Corp Ekstraktion af integrale membranproteiner
WO2001027275A1 (en) * 1999-10-13 2001-04-19 Lexicon Genetics Incorporated Novel human membrane proteins
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
CA2548378A1 (en) * 2003-12-30 2005-07-14 Bharat Biotech International Limited A process for the preparation and purification of recombinant proteins
EP2154149B1 (en) * 2007-05-29 2019-07-10 Xiamen University A truncated l1 protein of human papillomavirus 6
US20160130324A1 (en) 2014-10-31 2016-05-12 Shire Human Genetic Therapies, Inc. C1 Inhibitor Fusion Proteins and Uses Thereof
EP3377093B1 (en) 2015-11-19 2022-07-13 Takeda Pharmaceutical Company Limited Recombinant human c1 esterase inhibitor and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947324A (en) * 1975-04-21 1976-03-30 G. D. Searle And Co. Method for isolating high purity peroxidase
JPS6098988A (ja) * 1983-11-01 1985-06-01 Chemo Sero Therapeut Res Inst Lpf−haの精製法
EP0213099A3 (de) * 1985-08-23 1989-07-19 Cederroth Nordic Aktiebolag Mittel mit antiphlogistischer, immunstimulierender und zytoprotektiver Wirkung, ihre Herstellung und pharmazeutische Verwendungen
US4798886A (en) * 1986-03-24 1989-01-17 Takeda Chemical Industries, Ltd. Mutual separation of proteins
FR2597344B1 (fr) * 1986-04-16 1989-06-23 Merieux Inst Perfectionnement au procede de purification d'antigenes proteiques de bacteries appartenant au genre bordetella, en vue de l'obtention d'un vaccin acellulaire.
PL270368A1 (en) * 1987-01-30 1988-10-13 Int Minerals & Chem Corp Method for recovery of somatotropins from diluted water solutions
ATE95188T1 (de) * 1987-12-23 1993-10-15 Immuno Ag Zellulaere amphipatische proteine in aggregierten formen und verfahren zur herstellung und reinigung diese proteine.
US4992372A (en) * 1989-02-02 1991-02-12 Pokora Alexander R Method for removing impurities from peroxidase solutions
US5101014A (en) * 1989-02-10 1992-03-31 United States Of America Process for the purification of a 69,000 da outer membrane protein of Bordetella pertussis

Also Published As

Publication number Publication date
DK0499541T3 (da) 1996-12-02
FR2672895B1 (fr) 1995-05-12
DE69212660D1 (de) 1996-09-19
DE69212660T2 (de) 1997-03-13
ATE141283T1 (de) 1996-08-15
US5276141A (en) 1994-01-04
JP3376430B2 (ja) 2003-02-10
JPH04312600A (ja) 1992-11-04
FR2672895A1 (fr) 1992-08-21
CA2061167C (fr) 2002-06-11
EP0499541B1 (fr) 1996-08-14
EP0499541A1 (fr) 1992-08-19
CA2061167A1 (fr) 1992-08-16

Similar Documents

Publication Publication Date Title
ATE148130T1 (de) Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
UA39099C2 (uk) Циклічні азотовмісні похідні, суміш їх ізомерів або окремі ізомери, або їх солі
MX9304638A (es) Composicion para tratar e inhibir las ulceras gastricas y duodenales.
DK332684A (da) Modificerede protease-inhibitorer samt deres fremstilling og anvendelse
BR9502707A (pt) Composto composição farmacêutica e método para o tratamento de uma afecção
ATE214942T1 (de) Fibrinogen-bildungsprotein
WO1996013512A3 (en) L-ribofuranosyl nucleosides
BG99261A (en) Steroid glycosides for the treatment of hyperchlesterolemia
DE69830751D1 (de) Polyaromatische Verbindungen zur Behandlung von Herpes-Infektionen
FR2666996B1 (fr) Methode de purification d'un aminoacide utilisant une resine echangeuse d'ions.
DK0636173T3 (da) Behandling af HIV associeret immunthrombocytopenisk purpura
ES2092067T3 (es) Procedimiento de purificacion de una proteina altamente glicosilada.
AP9200410A0 (en) Retroviral protease inhibitors.
EP0511306A4 (en) Tumor killing effects of enterotoxins and related compounds
HK1048819B (zh) 新的配糖體、糖胺、酸、其中間體及其用途
DE69717843T2 (de) Cis-3,4-chromanderivate zur vorbeugung oder behandlungvon oestrogenbezogenen krankheiten oder syndromen
FI922551A0 (fi) Foerfarande foer skoetsel av septisk chock.
UA83989C2 (ru) Выделенный пептид, который стимулирует противоопухолевый иммунный ответ, фармацевтическая композиция на его основе и ее применение
DE69717844D1 (de) Neue cis-3,4-chromanderivate zur vorbeugung oder behandlung von oestrogenbezogenen krankheiten oder syndromen
BR9708648A (pt) Muteina de il-6
DK0858465T3 (da) Protein med antitumorvirkning.
ATE369847T1 (de) Aminoguanidine zur behandlung von diabetes typ ii
ATE95062T1 (de) Zusammensetzung zur behandlung von krebs, gekennzeichnet durch ueberexpression des c-fmsproto-onkogens.
RO86650B1 (ro) Preparat farmaceutic pentru tratarea dermatozelor
DE3884621D1 (de) Zusammensetzung zur behandlung von krebs, gekennzeichnet durch ueberexpression des c-fms-proto-onkogens.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 499541

Country of ref document: ES