ES2087962T3 - Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2087962T3
ES2087962T3 ES91202259T ES91202259T ES2087962T3 ES 2087962 T3 ES2087962 T3 ES 2087962T3 ES 91202259 T ES91202259 T ES 91202259T ES 91202259 T ES91202259 T ES 91202259T ES 2087962 T3 ES2087962 T3 ES 2087962T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
contain
preparation
methods
substituted nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91202259T
Other languages
English (en)
Inventor
Jan Maria Rene Balzarini
Clercq Erik Desire Alice De
Maria-Jose Camarasa-Rius
Maria-Jesus Perez-Perez
Ana San-Felix-Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stichting Rega VZW
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Stichting Rega VZW
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega VZW, Consejo Superior de Investigaciones Cientificas CSIC filed Critical Stichting Rega VZW
Application granted granted Critical
Publication of ES2087962T3 publication Critical patent/ES2087962T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTE INVENTO SE REFIERE A DERIVADOS NUCLEOSIDOS SUSTITUIDOS, SU SINTESIS QUIMICA Y COMPOSICIONES FARMACEUTICAS ACTIVAS ANTIVIRICAMENTE QUE CONTIENEN DICHOS DERIVADOS. SE HA DESCUBIERTO QUE ESTA NUEVA CLASE DE DERIVADOS SUSTITUIDOS MUESTRA UN EFECTO INHIBITORIO SELECTIVO SOBRE EL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH-1). LOS COMPUESTOS PREFERIDOS SON {1 IS LO] O 3 '''' - OXATHIOLE - 2'''', 2 - DIOXIDO).
ES91202259T 1991-09-04 1991-09-04 Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2087962T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91202259A EP0530407B1 (en) 1991-09-04 1991-09-04 Substituted, nucleoside derivatives, methods for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES2087962T3 true ES2087962T3 (es) 1996-08-01

Family

ID=8207858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91202259T Expired - Lifetime ES2087962T3 (es) 1991-09-04 1991-09-04 Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (9)

Country Link
US (1) US5527900A (es)
EP (1) EP0530407B1 (es)
JP (1) JPH0692986A (es)
AT (1) ATE138928T1 (es)
CA (1) CA2077466A1 (es)
DE (1) DE69120069T2 (es)
DK (1) DK0530407T3 (es)
ES (1) ES2087962T3 (es)
GR (1) GR3020783T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968910A (en) * 1994-11-30 1999-10-19 Jan M. R. Balzarini Compositions containing two or three inhibitors of different HIV reverse transcriptases
US5900381A (en) * 1997-08-26 1999-05-04 General Electric Company Opaque silica composition
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
AU753155B2 (en) 1998-01-23 2002-10-10 Kiadis Pharma Intellectual Property B.V. Enzyme catalyzed therapeutic agents
US6683061B1 (en) * 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
KR20020059341A (ko) 1999-07-22 2002-07-12 뉴바이오틱스 인코퍼레이티드 치료법-내성 종양의 치료 방법
BR112014019897A8 (pt) 2012-02-14 2017-07-11 Univ Georgia Espiro[2.4]heptanos para tratamento de infecções por flaviviridae

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties

Also Published As

Publication number Publication date
DE69120069T2 (de) 1996-10-02
DE69120069D1 (de) 1996-07-11
JPH0692986A (ja) 1994-04-05
DK0530407T3 (da) 1996-07-29
ATE138928T1 (de) 1996-06-15
US5527900A (en) 1996-06-18
CA2077466A1 (en) 1993-03-05
GR3020783T3 (en) 1996-11-30
EP0530407B1 (en) 1996-06-05
EP0530407A1 (en) 1993-03-10

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