ES2087962T3 - Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen. - Google Patents

Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen.

Info

Publication number
ES2087962T3
ES2087962T3 ES91202259T ES91202259T ES2087962T3 ES 2087962 T3 ES2087962 T3 ES 2087962T3 ES 91202259 T ES91202259 T ES 91202259T ES 91202259 T ES91202259 T ES 91202259T ES 2087962 T3 ES2087962 T3 ES 2087962T3
Authority
ES
Spain
Prior art keywords
pharmaceutical compositions
contain
preparation
methods
substituted nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91202259T
Other languages
English (en)
Inventor
Jan Maria Rene Balzarini
Clercq Erik Desire Alice De
Maria-Jose Camarasa-Rius
Maria-Jesus Perez-Perez
Ana San-Felix-Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Stichting Rega VZW
Consejo Superior de Investigaciones Cientificas CSIC
Original Assignee
Stichting Rega VZW
Consejo Superior de Investigaciones Cientificas CSIC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Rega VZW, Consejo Superior de Investigaciones Cientificas CSIC filed Critical Stichting Rega VZW
Application granted granted Critical
Publication of ES2087962T3 publication Critical patent/ES2087962T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTE INVENTO SE REFIERE A DERIVADOS NUCLEOSIDOS SUSTITUIDOS, SU SINTESIS QUIMICA Y COMPOSICIONES FARMACEUTICAS ACTIVAS ANTIVIRICAMENTE QUE CONTIENEN DICHOS DERIVADOS. SE HA DESCUBIERTO QUE ESTA NUEVA CLASE DE DERIVADOS SUSTITUIDOS MUESTRA UN EFECTO INHIBITORIO SELECTIVO SOBRE EL VIRUS DE INMUNODEFICIENCIA HUMANA (VIH-1). LOS COMPUESTOS PREFERIDOS SON {1 IS LO] O 3 '''' - OXATHIOLE - 2'''', 2 - DIOXIDO).
ES91202259T 1991-09-04 1991-09-04 Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen. Expired - Lifetime ES2087962T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91202259A EP0530407B1 (en) 1991-09-04 1991-09-04 Substituted, nucleoside derivatives, methods for their preparation and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ES2087962T3 true ES2087962T3 (es) 1996-08-01

Family

ID=8207858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91202259T Expired - Lifetime ES2087962T3 (es) 1991-09-04 1991-09-04 Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen.

Country Status (9)

Country Link
US (1) US5527900A (es)
EP (1) EP0530407B1 (es)
JP (1) JPH0692986A (es)
AT (1) ATE138928T1 (es)
CA (1) CA2077466A1 (es)
DE (1) DE69120069T2 (es)
DK (1) DK0530407T3 (es)
ES (1) ES2087962T3 (es)
GR (1) GR3020783T3 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968910A (en) * 1994-11-30 1999-10-19 Jan M. R. Balzarini Compositions containing two or three inhibitors of different HIV reverse transcriptases
US5900381A (en) * 1997-08-26 1999-05-04 General Electric Company Opaque silica composition
US7462605B2 (en) * 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
ES2172303T3 (es) 1998-01-23 2002-09-16 Newbiotics Inc Agentes terapeuticos obtenidos por catalisis enzimatica.
US6683061B1 (en) 1999-07-22 2004-01-27 Newbiotics, Inc. Enzyme catalyzed therapeutic activation
WO2001007088A2 (en) 1999-07-22 2001-02-01 Newbiotics, Inc. Methods for treating therapy-resistant tumors
WO2013123138A2 (en) 2012-02-14 2013-08-22 University Of Georgia Research Foundation, Inc. Spiro [2.4]heptanes for treatment of flaviviridae infections

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047407A (en) * 1989-02-08 1991-09-10 Iaf Biochem International, Inc. 2-substituted-5-substituted-1,3-oxathiolanes with antiviral properties

Also Published As

Publication number Publication date
ATE138928T1 (de) 1996-06-15
CA2077466A1 (en) 1993-03-05
US5527900A (en) 1996-06-18
EP0530407A1 (en) 1993-03-10
JPH0692986A (ja) 1994-04-05
DE69120069D1 (de) 1996-07-11
GR3020783T3 (en) 1996-11-30
DK0530407T3 (da) 1996-07-29
EP0530407B1 (en) 1996-06-05
DE69120069T2 (de) 1996-10-02

Similar Documents

Publication Publication Date Title
ES2062943B1 (es) Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas.
NO914356L (no) Mono n-substituerte 1,4,7,10-tetraazacyklododekanderivater, fremgangsmaater for fremstilling av dem og farmasoeytiskemidler som inneholder dem
DK0528734T3 (da) Thiaxolidin-2,4-dionderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
ES2137628T3 (es) Derivados de estilbeno y composiciones farmaceuticas que los contienen.
DK0618209T3 (da) Pyridothiadiaziner, fremgangsmåder til fremstilling heraf og farmaceutiske sammensætninger indeholdende dem
ES8304147A1 (es) Procedimiento para la preparacion de mono-esteres amonio-al-cohilicos de acidos alcanol-fosforicos
BR9812564A (pt) Amidas de ácido acilsulfamoilbenzóico, agentes protetores de plantas úteis contendo as mesmas e processos para a sua preparação
BR9909565A (pt) Derivados bicìclicos do ácido hidroxâmico
ES2142798T3 (es) Derivados de 3-amido pirazol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
ES2136037B1 (es) Inhibidores de sulfamida-metaloproteasa
DK0513543T3 (da) Amidinophenylalaninderivater, fremgangsmåde til deres fremstilling, deres anvendelse og antikoagulationsmidler med indehold deraf
NO930693L (no) Mometasonfuroatmonohydrat, fremgangsmaate for fremstillingav dette og farmasoeytiske preprater
ES2077399T3 (es) Derivados de poli-4-aminopirrol-2-carboxiamida, procedimientos para su preparacion y composiciones farmaceuticas que los contienen.
MX9306311A (es) Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ES2118711T3 (es) Sulfonilaminocarboniltriazolinonas con substituyentes enlazados.
ES2087962T3 (es) Derivados nucleosidos sustituidos, metodos para su preparacion y composiciones farmaceuticas que los contienen.
FR2686339B1 (fr) Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
ATE67756T1 (de) N-substituierte 3-piperidin- oder 3pyridincarbons|uren und deren derivate.
ES2150461T3 (es) Derivados de amidinofenilalanina, proceso para su preparacion, su empleo y agentes que los contienen como anticoagulantes.
MX9305510A (es) Compuestos para el tratamiento o profilaxis de desordenes gastrointestinales, cardiovasculares y del sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
HUP9902119A2 (hu) Difenil-stilbén származékok, mint Cox-2 inhibitorok és ezeket tartalmazó gyógyszerkészítmények
ES2148458T3 (es) Derivados de fenil-4-tiazoles sustituidos, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
DK0521393T3 (da) Dichlofenac-cholinsalt, fremgangsmåde til fremstilling deraf og farmaceutiske præparater der indeholder det
ES2094638T3 (es) N-acilpirrolidinas y medicamentos para el tratamiento o la prevencion de los desordenes relacionados con la colecistoquinina y la gastrina.
ATE158570T1 (de) Acylharnstoffe

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 530407

Country of ref document: ES