ES2087163T3 - Preparacion antitumoral que comprende intreleucina-2 e histamina, analogo al de las mismas o agonistas de receptor h2. - Google Patents

Preparacion antitumoral que comprende intreleucina-2 e histamina, analogo al de las mismas o agonistas de receptor h2.

Info

Publication number
ES2087163T3
ES2087163T3 ES90914257T ES90914257T ES2087163T3 ES 2087163 T3 ES2087163 T3 ES 2087163T3 ES 90914257 T ES90914257 T ES 90914257T ES 90914257 T ES90914257 T ES 90914257T ES 2087163 T3 ES2087163 T3 ES 2087163T3
Authority
ES
Spain
Prior art keywords
histamine
subject
agent
receptor agonists
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90914257T
Other languages
English (en)
Inventor
Jan Kristoffer Hellstrand
Svante Hermodsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxim Pharmaceuticals Inc
Original Assignee
Syntello Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntello Inc filed Critical Syntello Inc
Application granted granted Critical
Publication of ES2087163T3 publication Critical patent/ES2087163T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

UNA PREPARACION O SISTEMA PARA INHIBIR EL DESARROLLO DE TUMORES MALIGNOS Y LA FORMACION DE METASTASIS DE CELULAS DE TUMORES MALIGNOS, QUE COMPRENDE UNA PRIMERA COMPOSICION COMPRENDIENDO UN AGENTE SELECCIONADO DEL GRUPO QUE CONSISTE EN HISTAMINA, SUS ANALOGOS TENIENDO ACTIVIDAD RECEPTORA -H SUB 2, PREPARACIONES DE LIBERACION DE HISTAMINA ENDOGENAS Y AGONISTAS RECEPTORES -H SUB 2, Y UNA SEGUNDA COMPOSICION COMPRENDIENDO IL-2, MEZCLANDOSE DICHAS PRIMERA Y SEGUNDA COMPOSICIONES BIEN EN UNA PREPARACION O PROPORCIONADAS EN DOSIS SEPARADAS EN CANTIDAD SUFICIENTE PARA EL TRATAMIENTO DE TUMORES Y METASTASIS DE CELULAS TUMOROSAS MALIGNAS .
ES90914257T 1989-09-19 1990-09-19 Preparacion antitumoral que comprende intreleucina-2 e histamina, analogo al de las mismas o agonistas de receptor h2. Expired - Lifetime ES2087163T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40935789A 1989-09-19 1989-09-19

Publications (1)

Publication Number Publication Date
ES2087163T3 true ES2087163T3 (es) 1996-07-16

Family

ID=23620128

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90914257T Expired - Lifetime ES2087163T3 (es) 1989-09-19 1990-09-19 Preparacion antitumoral que comprende intreleucina-2 e histamina, analogo al de las mismas o agonistas de receptor h2.

Country Status (12)

Country Link
US (1) US5348739A (es)
EP (1) EP0493468B1 (es)
JP (1) JP2845622B2 (es)
KR (1) KR100195392B1 (es)
AT (1) ATE136786T1 (es)
AU (1) AU640954B2 (es)
CA (1) CA2066728C (es)
DE (1) DE69026620T2 (es)
DK (1) DK0493468T3 (es)
ES (1) ES2087163T3 (es)
NO (1) NO921050L (es)
WO (1) WO1991004037A1 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107771A0 (en) * 1992-11-27 1994-02-27 Wellcome Found Pharmaceutical compositions containing isothiourea derivatives certain such novel compounds and their preparation
EP0775197A1 (en) * 1994-08-08 1997-05-28 Maxim Pharmaceuticals, Inc. Enhanced activation of natural killer cells using an nk cell activator and a hydrogen peroxide scavenger or inhibitor
US7361332B2 (en) 1995-03-17 2008-04-22 The Regents Of The University Of California Treating tumors using implants comprising combinations of allogeneic cells
US6071942A (en) * 1996-05-14 2000-06-06 Maxim Pharmaceuticals, Inc. Elevation of circulating blood histamine levels
US5961969A (en) * 1996-05-14 1999-10-05 Maxim Pharmaceuticals, Inc. Stable circulating histamine levels
AU778012B2 (en) * 1996-05-14 2004-11-11 Maxim Pharmaceuticals, Inc. Administration of histamine for therapeutic purposes
AU9794698A (en) 1997-10-10 1999-05-03 Regents Of The University Of California, The Enhanced immunogenic cell populations prepared using h2 receptor antagonists
JP2002523378A (ja) * 1998-08-24 2002-07-30 マキシム ファーマシューティカルズ インコーポレイテッド Ｈ２−レセプターアゴニストおよび他のｔ−細胞活性化薬剤を用いたｔ−細胞（ｃｄ４＋およびｃｄ８＋）の活性化および保護
US6498181B1 (en) * 1999-01-06 2002-12-24 Maxim Pharmaceuticals Synergistic tumorcidal response induced by histamine
US6153113A (en) * 1999-02-22 2000-11-28 Cobe Laboratories, Inc. Method for using ligands in particle separation
JP2003505348A (ja) * 1999-07-16 2003-02-12 マキシム ファーマシューティカルス，インコーポレイテッド 反応性酸素代謝産物阻害剤を用いた細胞傷害性リンパ球の活性化および防御
US6354986B1 (en) 2000-02-16 2002-03-12 Gambro, Inc. Reverse-flow chamber purging during centrifugal separation
EP1536819A4 (en) * 2002-03-29 2007-10-17 Maxim Pharm Inc USING THE PRODUCTION OF REACTIVE OXYGEN METABOLITES (ROM) AND RELEASE INHIBITORS TO TREAT AND PREVENT INTRAOCULAR DAMAGE
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
WO2006039545A2 (en) * 2004-09-30 2006-04-13 Maxim Pharmaceuticals, Inc. Use of parp-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis
US7381722B2 (en) 2005-02-25 2008-06-03 Inotek Pharmaceuticals Corporation Tetracyclic amino and carboxamido compounds and methods of use thereof
KR20080039508A (ko) 2005-08-24 2008-05-07 이노텍 파마슈티컬스 코포레이션 인데노이소퀴놀리논 유사체 및 이의 사용 방법
CA2677046A1 (en) 2007-02-28 2008-09-04 Inotek Pharmaceuticals Corporation Indenoisoquinolinone analogs and methods of use thereof
WO2010120649A2 (en) * 2009-04-16 2010-10-21 Epicept Corporation Composition and use of n-alpha-methylhistamine dihydrochloride for the reduction of oxygen radical formation
WO2012150707A1 (ja) * 2011-05-02 2012-11-08 国立大学法人熊本大学 幹細胞からインスリン産生細胞への分化誘導を促進する低分子化合物および該化合物を用いた幹細胞からインスリン産生細胞への分化誘導方法
JP2020526576A (ja) * 2017-06-29 2020-08-31 イミューン・ファーマシューティカルズ・インコーポレイテッド 急性骨髄性白血病の再発を遅延及び予防する方法
WO2019023344A1 (en) * 2017-07-27 2019-01-31 Immune Pharmaceuticals, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF METASTATIC TUMORS

Also Published As

Publication number Publication date
AU6419190A (en) 1991-04-18
NO921050D0 (no) 1992-03-18
KR920703078A (ko) 1992-12-17
DE69026620T2 (de) 1996-10-02
AU640954B2 (en) 1993-09-09
EP0493468A1 (en) 1992-07-08
NO921050L (no) 1992-03-18
JP2845622B2 (ja) 1999-01-13
WO1991004037A1 (en) 1991-04-04
CA2066728C (en) 2001-12-25
DK0493468T3 (da) 1996-08-26
DE69026620D1 (de) 1996-05-23
JPH05504548A (ja) 1993-07-15
EP0493468B1 (en) 1996-04-17
KR100195392B1 (ko) 1999-06-15
CA2066728A1 (en) 1991-03-20
ATE136786T1 (de) 1996-05-15
US5348739A (en) 1994-09-20

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