ES2085832A1 - Profarmacos de la 5,5-difenilhidantoina. - Google Patents

Profarmacos de la 5,5-difenilhidantoina.

Info

Publication number
ES2085832A1
ES2085832A1 ES09401625A ES9401625A ES2085832A1 ES 2085832 A1 ES2085832 A1 ES 2085832A1 ES 09401625 A ES09401625 A ES 09401625A ES 9401625 A ES9401625 A ES 9401625A ES 2085832 A1 ES2085832 A1 ES 2085832A1
Authority
ES
Spain
Prior art keywords
phenytoin
propharmacs
hydantoine
diphenyl
product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09401625A
Other languages
English (en)
Other versions
ES2085832B1 (es
Inventor
Estrem Tomas Roca
Cartes Joan Bosch
Berrozpe Josep Domenech
Vidal Rossend Obach
Zurita Pelayo Rubio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Rubio SA
Original Assignee
Laboratorios Rubio SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Rubio SA filed Critical Laboratorios Rubio SA
Priority to ES09401625A priority Critical patent/ES2085832B1/es
Priority to EP95500085A priority patent/EP0693481A1/en
Priority to IL114236A priority patent/IL114236A/en
Priority to JP7185350A priority patent/JPH08183777A/ja
Publication of ES2085832A1 publication Critical patent/ES2085832A1/es
Application granted granted Critical
Publication of ES2085832B1 publication Critical patent/ES2085832B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROFARMACOS DE LA 5,5-DIFENILHIDANTOINA. LA PRESENTE INVENCION TRATA DE UN PRODUCTO DE FORMULA (I), QUE ES UN NUEVO PROFARMACO DE LA FENITOINA, ASI COMO DE SUS SOLVATOS Y DE SUS SALES DE ADICION TERAPEUTICAMENTE ACEPTABLES. ESTE PRODUCTO PRESENTA UNA SOLUBILIDAD SIGNIFICATIVAMENTE MAYOR QUE LA PROPIA FENITOINA. ADEMAS, SORPRENDENTEMENTE, SU VELOCIDAD DE HIDROLISIS ES MUCHO MAYOR QUE LA DE OTROS PROFARMACOS CONOCIDOS DE LA FENITOINA, LO QUE LO CONVIERTE EN POTENCIALMENTE UTIL COMO AGENTE ANTIEPILEPTICO Y ANTIARRITMICO.
ES09401625A 1994-07-22 1994-07-22 Profarmacos de la 5,5-difenilhidantoina. Expired - Fee Related ES2085832B1 (es)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ES09401625A ES2085832B1 (es) 1994-07-22 1994-07-22 Profarmacos de la 5,5-difenilhidantoina.
EP95500085A EP0693481A1 (en) 1994-07-22 1995-06-14 Prodrugs of 5,5-diphenylhydantoin as antiepileptic and antiarrhythmic agents
IL114236A IL114236A (en) 1994-07-22 1995-06-20 5, 5-diphenylhydantoin derivatives, pharmaceutical compositions containing the same and a process for the preparation thereof
JP7185350A JPH08183777A (ja) 1994-07-22 1995-07-21 ５、５−ジフェニルヒダントインのプロドラッグ

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09401625A ES2085832B1 (es) 1994-07-22 1994-07-22 Profarmacos de la 5,5-difenilhidantoina.

Publications (2)

Publication Number Publication Date
ES2085832A1 true ES2085832A1 (es) 1996-06-01
ES2085832B1 ES2085832B1 (es) 1997-01-16

Family

ID=8287022

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09401625A Expired - Fee Related ES2085832B1 (es) 1994-07-22 1994-07-22 Profarmacos de la 5,5-difenilhidantoina.

Country Status (4)

Country Link
EP (1) EP0693481A1 (es)
JP (1) JPH08183777A (es)
ES (1) ES2085832B1 (es)
IL (1) IL114236A (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3120986A1 (en) * 2018-11-27 2020-06-04 Eagle Research Labs Limited Use of dantrolene and dantrolene prodrugs to treat radiation exposure

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163058A (en) * 1977-04-22 1979-07-31 Interx Research Corporation Derivatives of 5,5-diphenylhydantoin exhibiting enhanced solubility and the therapeutic use thereof
EP0327766A2 (en) * 1987-12-30 1989-08-16 University Of Florida Redox systems for brain-targeted drug delivery

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4260769A (en) 1977-04-22 1981-04-07 Interx Research Corporation 5,5-Diphenylhydantoins
DK24089D0 (da) 1989-01-20 1989-01-20 Hans Bundgaard Novel prodrug derivatives of biologically active agents containing hydroxyl groups or nh-acidic groups

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163058A (en) * 1977-04-22 1979-07-31 Interx Research Corporation Derivatives of 5,5-diphenylhydantoin exhibiting enhanced solubility and the therapeutic use thereof
EP0327766A2 (en) * 1987-12-30 1989-08-16 University Of Florida Redox systems for brain-targeted drug delivery

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHEK, E. y col. Improved Anticonvulsant Activity of Phenytoin by a Redox Brain Delivery System III: Brain Uptake and Pharmacological Effects. Journal of Pharmaceutical Sciences, Octubre 1989, Vol. 78, N‘ 10, páginas 837-843 * Fórmulas 6a,6b * *

Also Published As

Publication number Publication date
JPH08183777A (ja) 1996-07-16
ES2085832B1 (es) 1997-01-16
EP0693481A1 (en) 1996-01-24
IL114236A0 (en) 1995-10-31
IL114236A (en) 1998-06-15

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