ES2085350T3 - Analogos viia del factor de liberacion de la hormona de crecimiento. - Google Patents
Analogos viia del factor de liberacion de la hormona de crecimiento.Info
- Publication number
- ES2085350T3 ES2085350T3 ES90907830T ES90907830T ES2085350T3 ES 2085350 T3 ES2085350 T3 ES 2085350T3 ES 90907830 T ES90907830 T ES 90907830T ES 90907830 T ES90907830 T ES 90907830T ES 2085350 T3 ES2085350 T3 ES 2085350T3
- Authority
- ES
- Spain
- Prior art keywords
- arg
- ala
- leu
- phe
- ser
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Oscillators With Electromechanical Resonators (AREA)
- Amplifiers (AREA)
- Electrophonic Musical Instruments (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
LA INVENCION PROVEE PEPTIDAS SINTETICAS, LAS CUALES SON EXTREMADAMENTE POTENTES ESTIMULANDO LA LIBERACION DE GH PITUITARIA EN ANIMALES, INCLUYENDO AL HOMBRE, Y TAMBIEN RESISTENCIA A LA DEGRADACION ENZIMATICA EN EL CUERPO. LAS PEPTIDAS TIENEN LA SECUENCIA: (B)R1-R2-R3-ALA....... ....... EN DONDE R1 ES TYR,.. ...., HIS O D-HIS; B ES H,...., DIETILESTILBESTROLAMINO, AC O FOR; R2 ES ALA, D-ALA, NMA O D-NMA; R3 ES ASP O D-ASP; R5 ES ILE O LEU; R8 ES SER, ASN, LYS, ARG, ASP O GLU; R10 ES TYR, D-TYR O PHE; R12 ES ARG O LYS; R13 ES ILE, VAL, LEU O ALA; R15 ES GLY O ALA; R18 ES SER O TYR; R21 ES LYS, D-LYS, ARG O D-ARG; R22 ES LEU, ILE, ALA O VAL;R24 ES GLN O HIS; R25 ES ASP O GLU; R26 ES ILE O LEU; R27 ES MET, D-MET, ALA, NLE, ILE, LEU, NVA O VAL; R28 ES ASN O SER; R34 ES SER O ARG; R38 ES ARG O GLN; R39 ES GLY O ARG; R40 ES ALA O SER; R42 ES PHE, ALA O VAL; R43 ES ASN O ARG; R44 ES UN AMINO ACIDO NATURAL; Q1-Q9 SON O H O CAME, PROVISTO NO OBSTANTE QUE UNO DE LOS Q1, Q4, Q7, Q8 Y Q9 SEA CAME. ESTASPEPTIDAS TAMBIEN SE PUEDEN USAR PARA DIAGNOSTICO, Y EL TERMINO C SE PUEDE REDUCIR AL RESIDUO 29.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/342,751 US5098995A (en) | 1987-05-22 | 1989-04-25 | GRF Analogs VIIA |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2085350T3 true ES2085350T3 (es) | 1996-06-01 |
Family
ID=23343123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90907830T Expired - Lifetime ES2085350T3 (es) | 1989-04-25 | 1990-04-24 | Analogos viia del factor de liberacion de la hormona de crecimiento. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5098995A (es) |
EP (1) | EP0423322B1 (es) |
JP (1) | JP2974254B2 (es) |
KR (1) | KR0163033B1 (es) |
AT (1) | ATE133687T1 (es) |
AU (1) | AU628558B2 (es) |
CA (1) | CA2030810C (es) |
DE (1) | DE69025123T2 (es) |
DK (1) | DK0423322T3 (es) |
ES (1) | ES2085350T3 (es) |
FI (1) | FI94356C (es) |
IL (1) | IL94171A (es) |
NO (1) | NO178031C (es) |
WO (1) | WO1990012810A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5756458A (en) * | 1989-06-16 | 1998-05-26 | Pharmacia & Upjohn Company | Stabilized potent GRF analogs |
AU1879892A (en) * | 1991-04-24 | 1992-12-21 | Warner-Lambert Company | Cck analogs containing alpha-substituted amino acids |
CA2106764A1 (en) * | 1991-04-24 | 1992-10-25 | David C. Horwell | Ó-substituted polypeptides having therapeutic activity |
US5262519A (en) * | 1991-05-15 | 1993-11-16 | The Salk Institute For Biological Studies | GRF analogs XI |
CA2158782C (en) * | 1994-09-23 | 2010-01-12 | Pierrette Gaudreau | Marker for growth hormone-releasing factor receptors |
EP1499888B1 (en) * | 2002-04-29 | 2010-07-07 | Euro-Celtique S.A. | Conformationally constrained peptides that bind the orl-1 receptor |
US9079974B2 (en) * | 2011-12-21 | 2015-07-14 | The University Of Miami | GH-RH analogs with potent agonistic effects |
WO2014100816A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for islet cell transplantation and function and the treatment of diabetes |
WO2014100809A2 (en) | 2012-12-21 | 2014-06-26 | University Of Miami | Ghrh agonists for the treatment of ischemic disorders |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4728726A (en) * | 1982-10-04 | 1988-03-01 | The Salk Institute For Biological Studies | GRF analogs IIIb |
US4594329A (en) * | 1984-05-14 | 1986-06-10 | The Salk Institute For Biological Studies | CRF analogs |
US4689318A (en) * | 1985-08-29 | 1987-08-25 | The Salk Institute For Biological Studies | GRF analogs |
US5002931A (en) * | 1987-05-22 | 1991-03-26 | The Salk Institute For Biological Studies | GRF analogs VII |
-
1989
- 1989-04-25 US US07/342,751 patent/US5098995A/en not_active Expired - Lifetime
-
1990
- 1990-04-23 IL IL9417190A patent/IL94171A/en not_active IP Right Cessation
- 1990-04-24 CA CA002030810A patent/CA2030810C/en not_active Expired - Fee Related
- 1990-04-24 AT AT90907830T patent/ATE133687T1/de not_active IP Right Cessation
- 1990-04-24 DK DK90907830.5T patent/DK0423322T3/da active
- 1990-04-24 JP JP2507102A patent/JP2974254B2/ja not_active Expired - Fee Related
- 1990-04-24 WO PCT/US1990/002224 patent/WO1990012810A1/en active IP Right Grant
- 1990-04-24 KR KR1019900702671A patent/KR0163033B1/ko not_active IP Right Cessation
- 1990-04-24 ES ES90907830T patent/ES2085350T3/es not_active Expired - Lifetime
- 1990-04-24 AU AU55569/90A patent/AU628558B2/en not_active Ceased
- 1990-04-24 EP EP90907830A patent/EP0423322B1/en not_active Expired - Lifetime
- 1990-04-24 DE DE69025123T patent/DE69025123T2/de not_active Expired - Fee Related
- 1990-12-18 FI FI906240A patent/FI94356C/fi not_active IP Right Cessation
- 1990-12-20 NO NO905505A patent/NO178031C/no unknown
Also Published As
Publication number | Publication date |
---|---|
DK0423322T3 (da) | 1996-06-24 |
AU5556990A (en) | 1990-11-16 |
NO178031C (no) | 1996-01-10 |
FI94356B (fi) | 1995-05-15 |
WO1990012810A1 (en) | 1990-11-01 |
DE69025123T2 (de) | 1996-09-19 |
EP0423322B1 (en) | 1996-01-31 |
AU628558B2 (en) | 1992-09-17 |
NO178031B (no) | 1995-10-02 |
CA2030810A1 (en) | 1990-10-26 |
FI906240A0 (fi) | 1990-12-18 |
CA2030810C (en) | 1999-12-14 |
NO905505D0 (no) | 1990-12-20 |
US5098995A (en) | 1992-03-24 |
EP0423322A1 (en) | 1991-04-24 |
FI94356C (fi) | 1995-08-25 |
JPH04500526A (ja) | 1992-01-30 |
NO905505L (no) | 1991-02-20 |
ATE133687T1 (de) | 1996-02-15 |
JP2974254B2 (ja) | 1999-11-10 |
KR920700225A (ko) | 1992-02-19 |
KR0163033B1 (ko) | 1998-11-16 |
IL94171A0 (en) | 1991-01-31 |
DE69025123D1 (de) | 1996-03-14 |
IL94171A (en) | 1994-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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