ES2084622T3 - Derivados de pirrolo(2,1-b)tiazol. - Google Patents
Derivados de pirrolo(2,1-b)tiazol.Info
- Publication number
- ES2084622T3 ES2084622T3 ES90113378T ES90113378T ES2084622T3 ES 2084622 T3 ES2084622 T3 ES 2084622T3 ES 90113378 T ES90113378 T ES 90113378T ES 90113378 T ES90113378 T ES 90113378T ES 2084622 T3 ES2084622 T3 ES 2084622T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- substitutes
- molecula
- aril
- rental
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title 1
- -1 HYDROXYL GROUP Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical group [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 150000003973 alkyl amines Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Detergent Compositions (AREA)
- Pyrrole Compounds (AREA)
Abstract
SE PRESENTA UN NUEVO COMPUESTO REPRESENTADO POR LA FORMULA (I) EN LA QUE R1 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL O UN GRUPO ALQUIL CICLICO; R2 REPRESENTA UN GRUPO HIDROXIL, UN GRUPO ALCOXIDO QUE PUEDE TENER DE 1 A 3 SUBSTITUYENTES EN LA MOLECULA DEL GRUPO ALQUIL, UN GRUPO ARILTIO QUE PUEDE TENER 1 O MAS SUBSTITUYENTES EN LA MOLECULA DEL GRUPO ARIL, UN GRUPO ARILOXIDO QUE PUEDE TENER UNO O MAS SUBSTITUYENTES EN LA MOLECULA DEL GRUPO ARIL, UN GRUMO AMINO, UN GRUPO ALQUILAMINO, O UN GRUPO AMINO CICLICO QUE PUEDE CONTENER OTROS ATOMOS ETEROS COMO ATOMOS DEL ANILLO SELECCIONADOS ENTRE UN ATOMO DE NITROGENO, UN ATOMO DE OXIGENO Y UN ATOMO DE AZUFRE; R3 REPRESENTA UN ATOMO DE HIDROGENO, UN GRUPO ALQUIL, UN GRUPO ARIL QUE PUEDE TENER UNO O MAS SUBSTITUYENTES O UN GRUPO ARIL ETERO QUE PUEDE TENER UNO O MAS SUBSTITUYENTES; REPRESNTAN UN ENLACE SIMPLE O UN DOBLE ENLACE. TAMBIEN SE PRESENTAN LAS SALES DE DICHO COMPUESTO Y LAS PREPARACIONES FARMACEUTICAS PARA EVITAR Y TRATAR ENFERMEDADES HEPATICAS CONTENIENDO EL COMPUESTO DE LA FORMULA (I) O LAS SALES DEL MISMO COMO INGREDIENTES ACTIVOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15114189 | 1989-06-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2084622T3 true ES2084622T3 (es) | 1996-05-16 |
Family
ID=15512262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90113378T Expired - Lifetime ES2084622T3 (es) | 1989-06-13 | 1990-07-12 | Derivados de pirrolo(2,1-b)tiazol. |
Country Status (23)
Country | Link |
---|---|
US (1) | US5098919A (es) |
EP (1) | EP0410224B1 (es) |
JP (1) | JP2875605B2 (es) |
KR (1) | KR910002874A (es) |
CN (1) | CN1025337C (es) |
AT (1) | ATE132870T1 (es) |
AU (1) | AU624724B2 (es) |
CA (1) | CA2021135A1 (es) |
DD (1) | DD296492A5 (es) |
DE (1) | DE69024713T2 (es) |
DK (1) | DK0410224T3 (es) |
ES (1) | ES2084622T3 (es) |
FI (1) | FI903511A0 (es) |
GR (1) | GR3018798T3 (es) |
HU (1) | HU207331B (es) |
IE (1) | IE902545A1 (es) |
IL (1) | IL95021A (es) |
NO (1) | NO903084L (es) |
NZ (1) | NZ234450A (es) |
PT (1) | PT94688A (es) |
RU (2) | RU1836374C (es) |
YU (1) | YU136490A (es) |
ZA (1) | ZA905407B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050244892A1 (en) * | 2004-02-27 | 2005-11-03 | Lazar Mitchell A | Resistin as a marker and therapeutic target for cardiovascular disease |
WO2009124978A1 (en) * | 2008-04-09 | 2009-10-15 | Brahms Aktiengesellschaft | Pro-endothelin-1 for the prediction of impaired peak oxygen consumption |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4193926A (en) * | 1974-03-20 | 1980-03-18 | Schering Aktiengesellschaft | 4-(Polyalkoxy phenyl)-2-pyrrolidones |
US4347186A (en) * | 1980-10-20 | 1982-08-31 | Syntex (U.S.A.) Inc. | Process for preparing 5-aroyl 1,2-dihydro-3-H pyrrolo[1,2-a]pyrrole-1-carboxylic acids and novel intermediates therein |
-
1990
- 1990-07-10 IL IL9502190A patent/IL95021A/en not_active IP Right Cessation
- 1990-07-10 ZA ZA905407A patent/ZA905407B/xx unknown
- 1990-07-10 DD DD90342652A patent/DD296492A5/de not_active IP Right Cessation
- 1990-07-11 NO NO90903084A patent/NO903084L/no unknown
- 1990-07-11 AU AU58904/90A patent/AU624724B2/en not_active Ceased
- 1990-07-11 FI FI903511A patent/FI903511A0/fi not_active Application Discontinuation
- 1990-07-11 KR KR1019900010442A patent/KR910002874A/ko not_active Application Discontinuation
- 1990-07-11 NZ NZ234450A patent/NZ234450A/xx unknown
- 1990-07-12 EP EP90113378A patent/EP0410224B1/en not_active Expired - Lifetime
- 1990-07-12 YU YU136490A patent/YU136490A/sh unknown
- 1990-07-12 RU SU904830592A patent/RU1836374C/ru active
- 1990-07-12 DK DK90113378.5T patent/DK0410224T3/da active
- 1990-07-12 DE DE69024713T patent/DE69024713T2/de not_active Expired - Fee Related
- 1990-07-12 ES ES90113378T patent/ES2084622T3/es not_active Expired - Lifetime
- 1990-07-12 AT AT90113378T patent/ATE132870T1/de not_active IP Right Cessation
- 1990-07-12 PT PT94688A patent/PT94688A/pt not_active Application Discontinuation
- 1990-07-12 IE IE254590A patent/IE902545A1/en unknown
- 1990-07-13 US US07/552,031 patent/US5098919A/en not_active Expired - Fee Related
- 1990-07-13 CA CA002021135A patent/CA2021135A1/en not_active Abandoned
- 1990-07-13 JP JP2186896A patent/JP2875605B2/ja not_active Expired - Fee Related
- 1990-07-13 CN CN90107066A patent/CN1025337C/zh not_active Expired - Fee Related
- 1990-07-13 HU HU904214A patent/HU207331B/hu not_active IP Right Cessation
-
1991
- 1991-08-22 RU SU915001347A patent/RU2026288C1/ru active
-
1996
- 1996-01-25 GR GR960400186T patent/GR3018798T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0410224T3 (da) | 1996-02-05 |
RU2026288C1 (ru) | 1995-01-09 |
RU1836374C (ru) | 1993-08-23 |
AU624724B2 (en) | 1992-06-18 |
HU904214D0 (en) | 1990-12-28 |
EP0410224A1 (en) | 1991-01-30 |
NO903084D0 (no) | 1990-07-11 |
DE69024713D1 (de) | 1996-02-22 |
IL95021A (en) | 1994-06-24 |
CN1049350A (zh) | 1991-02-20 |
HUT57221A (en) | 1991-11-28 |
NO903084L (no) | 1991-01-14 |
NZ234450A (en) | 1991-10-25 |
ATE132870T1 (de) | 1996-01-15 |
CN1025337C (zh) | 1994-07-06 |
IE902545A1 (en) | 1991-02-27 |
DE69024713T2 (de) | 1996-06-13 |
EP0410224B1 (en) | 1996-01-10 |
US5098919A (en) | 1992-03-24 |
JPH03128385A (ja) | 1991-05-31 |
FI903511A0 (fi) | 1990-07-11 |
PT94688A (pt) | 1991-03-20 |
GR3018798T3 (en) | 1996-04-30 |
IL95021A0 (en) | 1991-06-10 |
JP2875605B2 (ja) | 1999-03-31 |
CA2021135A1 (en) | 1991-01-14 |
ZA905407B (en) | 1991-04-24 |
KR910002874A (ko) | 1991-02-26 |
HU207331B (en) | 1993-03-29 |
AU5890490A (en) | 1991-01-17 |
DD296492A5 (de) | 1991-12-05 |
YU136490A (sh) | 1992-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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