ES2083074T3 - Dispositivo de liberacion controlada. - Google Patents
Dispositivo de liberacion controlada.Info
- Publication number
- ES2083074T3 ES2083074T3 ES92203447T ES92203447T ES2083074T3 ES 2083074 T3 ES2083074 T3 ES 2083074T3 ES 92203447 T ES92203447 T ES 92203447T ES 92203447 T ES92203447 T ES 92203447T ES 2083074 T3 ES2083074 T3 ES 2083074T3
- Authority
- ES
- Spain
- Prior art keywords
- active substance
- exposed
- dissolution
- fluid
- nucleus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000013270 controlled release Methods 0.000 title 1
- 239000013543 active substance Substances 0.000 abstract 5
- 238000004090 dissolution Methods 0.000 abstract 4
- 239000012530 fluid Substances 0.000 abstract 4
- 239000011159 matrix material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 abstract 1
- 229960000620 ranitidine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Molding Of Porous Articles (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Seal Device For Vehicle (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Container, Conveyance, Adherence, Positioning, Of Wafer (AREA)
Abstract
EL INVENTO MUESTRA UN DISPOSITIVO PARA LA LIBERACION DE AL MENOS UNA SUSTANCIA ACTIVA (POR EJEMPLO RANITIDINA) EN UN MEDIO DE FLUIDO POR DISOLUCION QUE COMPRENDE UNA COBERTURA, QUE ES IMPERMEABLE A LA SUSTANCIA ACTIVA Y EL FLUIDO, CON AL MENOS UNA ABERTURA EN SU INTERIOR Y QUE DEFINE UNA CAVIDAD LLENA DE UN NUCLEO QUE COMPRENDE LA SUSTANCIA ACTIVA Y EN DONDE: A) AL EXPONER EL DISPOSITIVO AL MEDIO DE FLUIDO, SE EXPONE UNA SUPERFICIE DEL NUCLEO Y LA DISOLUCION DE LA SUPERFICIE POR EL MEDIO DE FLUIDO PROVOCA UN CAMBIO AL MENOS EN UNA DIMENSION DEL AREA DE LA SUPERFICIE, MIENTRAS QUE EL AREA SUPERFICIAL DE LA SUPERFICIE EXPUESTA PERMANECE BASICAMENTE CONSTANTE EN AL MENOS UN 50% DEL TIEMPO DE DISOLUCION TOTAL EN EL NUCLEO; O B) LA SUSTANCIA ACTIVA SE EXPONE EN UNA MATRIZ DE EXCIPIENTE INSOLUBLE INERTE, ESTANDO EL DISPOSITIVO AXIALMENTE SIMETRICO, CON SU ABERTURA COLOCADA PERIFERICAMENTE DE MODO QUE LA SUPERFICIE DE LIBERACION DEL NUCLEO QUE ESTA EXPUESTO A TRAVES DE LA ABERTURA SEA BASICAMENTECILINDRICA O PARCIALMENTE CILINDRICA EN FORMA, POR LO QUE PERMITE BASICAMENTE LA LIBERACION CONSTANTE DE LA SUSTANCIA ACTIVA AL MENOS DURANTE PARTE DEL TIEMPO DE DISOLUCION; ASI COMO PROCESOS PARA SU PREPARACION.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919124106A GB9124106D0 (en) | 1991-11-13 | 1991-11-13 | Device |
GB919124108A GB9124108D0 (en) | 1991-11-13 | 1991-11-13 | Device |
GB929205463A GB9205463D0 (en) | 1992-03-12 | 1992-03-12 | Device |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2083074T3 true ES2083074T3 (es) | 1996-04-01 |
Family
ID=27265924
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92203447T Expired - Lifetime ES2083074T3 (es) | 1991-11-13 | 1992-11-10 | Dispositivo de liberacion controlada. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5342627A (es) |
EP (1) | EP0542364B1 (es) |
JP (2) | JP3768247B2 (es) |
AT (1) | ATE133331T1 (es) |
AU (1) | AU658942B2 (es) |
CA (1) | CA2082740C (es) |
CZ (1) | CZ337392A3 (es) |
DE (1) | DE69207863T2 (es) |
DK (1) | DK0542364T3 (es) |
ES (1) | ES2083074T3 (es) |
GR (1) | GR3019431T3 (es) |
IL (1) | IL103723A0 (es) |
NO (1) | NO924372L (es) |
NZ (1) | NZ245100A (es) |
TW (1) | TW262387B (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5398850A (en) | 1993-08-06 | 1995-03-21 | River Medical, Inc. | Gas delivery apparatus for infusion |
DE4341442C2 (de) * | 1993-12-04 | 1998-11-05 | Lohmann Therapie Syst Lts | Vorrichtung zur kontrollierten Freisetzung von Wirkstoffen sowie ihre Verwendung |
DE4431653C2 (de) | 1994-09-06 | 2000-01-20 | Lohmann Therapie Syst Lts | Manteltablette zur kontrollierten Freisetzung von Wirkstoffen, ein Verfahren zu ihrer Herstellung und ihre Verwendung |
US5700245A (en) | 1995-07-13 | 1997-12-23 | Winfield Medical | Apparatus for the generation of gas pressure for controlled fluid delivery |
US5773031A (en) * | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
US6110500A (en) * | 1998-03-25 | 2000-08-29 | Temple University | Coated tablet with long term parabolic and zero-order release kinetics |
EP1095650A1 (en) * | 1999-10-29 | 2001-05-02 | Universiteit Leiden | Double phase time-controlled release system |
US6569152B2 (en) | 2000-03-21 | 2003-05-27 | Farrington Pharmaceuticals, Llc | Sustained release delivery systems for solutes |
CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
WO2002047693A2 (en) * | 2000-12-14 | 2002-06-20 | Ortho-Mcneil Pharmaceutical, Inc. | Steroid hormone products comprising a stabilizing agent in non-crystalline form |
US6960357B2 (en) | 2001-05-25 | 2005-11-01 | Mistral Pharma Inc. | Chemical delivery device |
US20070196415A1 (en) * | 2002-11-14 | 2007-08-23 | Guohua Chen | Depot compositions with multiple drug release rate controls and uses thereof |
EP1446100B1 (en) * | 2001-11-14 | 2011-05-04 | Durect Corporation | Injectable depot compositions and uses thereof |
NZ533436A (en) | 2001-11-14 | 2007-10-26 | Alza Corp | Catheter injectable depot compositons and uses thereof |
GB0203296D0 (en) * | 2002-02-12 | 2002-03-27 | Glaxo Group Ltd | Novel composition |
US7125563B2 (en) * | 2002-04-12 | 2006-10-24 | Dava Pharmaceuticals, Inc. | Sustained release pharmaceutical preparations and methods for producing the same |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
US8637512B2 (en) * | 2002-07-29 | 2014-01-28 | Glaxo Group Limited | Formulations and method of treatment |
JP4744142B2 (ja) * | 2002-07-29 | 2011-08-10 | グラクソ グループ リミテッド | ラモトリギンを含む徐放性処方 |
KR20050038008A (ko) * | 2002-07-31 | 2005-04-25 | 알자 코포레이션 | 주사용 저장형 조성물 및 이의 용도 |
DK1539101T3 (da) * | 2002-07-31 | 2009-04-27 | Alza Corp | Injicerbare, multi-modale polymere depotsammens tninger og anvendelser deraf |
US20040068000A1 (en) * | 2002-10-02 | 2004-04-08 | Mintong Guo | Compression coated tablets |
GB0400452D0 (en) * | 2004-01-09 | 2004-02-11 | Norton Healthcare Ltd | A pharmaceutical composition |
US20050163847A1 (en) * | 2004-01-21 | 2005-07-28 | Andrx Pharmaceuticals, Llc | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and an antiulcerative drug |
GB0403628D0 (en) * | 2004-02-18 | 2004-03-24 | Arrow Group Ltd | Compression-coated tablets and the manufacture thereof |
CA2575988C (en) | 2004-08-04 | 2014-02-18 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
GB0423964D0 (en) * | 2004-10-28 | 2004-12-01 | Jagotec Ag | Dosage form |
US20060142234A1 (en) * | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
WO2007073702A2 (es) | 2005-12-29 | 2007-07-05 | Osmotica Corp. | Comprimido multicapa con combinación de triple liberación |
US8691272B2 (en) * | 2005-12-30 | 2014-04-08 | Intelgenx Corp. | Multilayer tablet |
DE102007026037A1 (de) | 2007-06-04 | 2008-12-11 | Lts Lohmann Therapie-Systeme Ag | Gastroretentives System mit Alginat-Körper |
WO2009085952A1 (en) | 2007-12-20 | 2009-07-09 | Brookwood Pharmaceuticals, Inc. | Process for preparing microparticles having a low residual solvent volume |
US20110142905A1 (en) * | 2008-08-14 | 2011-06-16 | Bioneer A/S | Coated tablets with remaining degradation surface over the time |
WO2010096820A1 (en) * | 2009-02-23 | 2010-08-26 | Eurand, Inc. | Controlled release compositions comprising anti-cholinergic drugs |
US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
EP2544667B1 (en) * | 2010-03-09 | 2018-11-14 | Alkermes Pharma Ireland Limited | Alcohol resistant enteric pharmaceutical compositions |
AU2011342893A1 (en) * | 2010-12-13 | 2013-05-02 | Purdue Pharma L.P. | Controlled release dosage forms |
US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
US9988669B2 (en) | 2014-04-14 | 2018-06-05 | Abbott Molecular Inc. | Medium used for blood sample collection and transport |
CA2936746C (en) | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
CA3167217A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US480076A (en) * | 1892-08-02 | Thomas p | ||
US3113076A (en) * | 1956-07-03 | 1963-12-03 | Henry R Jacobs | Medicinal tablets |
GB1022171A (en) * | 1961-06-15 | 1966-03-09 | Wellcome Found | Prolonged release oral pharmaceutical tablets and their manufacture |
US3851648A (en) * | 1973-10-11 | 1974-12-03 | Mead Johnson & Co | Zero-order release device |
US4816262A (en) * | 1986-08-28 | 1989-03-28 | Universite De Montreal | Controlled release tablet |
US4803076A (en) * | 1986-09-04 | 1989-02-07 | Pfizer Inc. | Controlled release device for an active substance |
-
1992
- 1992-11-10 AT AT92203447T patent/ATE133331T1/de not_active IP Right Cessation
- 1992-11-10 ES ES92203447T patent/ES2083074T3/es not_active Expired - Lifetime
- 1992-11-10 DK DK92203447.5T patent/DK0542364T3/da active
- 1992-11-10 EP EP92203447A patent/EP0542364B1/en not_active Expired - Lifetime
- 1992-11-10 DE DE69207863T patent/DE69207863T2/de not_active Expired - Lifetime
- 1992-11-11 AU AU28272/92A patent/AU658942B2/en not_active Ceased
- 1992-11-12 NO NO92924372A patent/NO924372L/no unknown
- 1992-11-12 NZ NZ245100A patent/NZ245100A/en unknown
- 1992-11-12 CZ CS923373A patent/CZ337392A3/cs unknown
- 1992-11-12 US US07/975,079 patent/US5342627A/en not_active Expired - Lifetime
- 1992-11-12 IL IL103723A patent/IL103723A0/xx unknown
- 1992-11-12 CA CA002082740A patent/CA2082740C/en not_active Expired - Lifetime
- 1992-11-13 JP JP32843092A patent/JP3768247B2/ja not_active Expired - Lifetime
- 1992-11-23 TW TW081109348A patent/TW262387B/zh active
-
1996
- 1996-03-27 GR GR960400817T patent/GR3019431T3/el unknown
-
2004
- 2004-03-12 JP JP2004071512A patent/JP4166716B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU658942B2 (en) | 1995-05-04 |
JP4166716B2 (ja) | 2008-10-15 |
EP0542364B1 (en) | 1996-01-24 |
EP0542364A1 (en) | 1993-05-19 |
DE69207863D1 (de) | 1996-03-07 |
DE69207863T2 (de) | 1996-06-05 |
GR3019431T3 (en) | 1996-06-30 |
JP2004189754A (ja) | 2004-07-08 |
ATE133331T1 (de) | 1996-02-15 |
US5342627A (en) | 1994-08-30 |
CA2082740C (en) | 2003-10-14 |
TW262387B (es) | 1995-11-11 |
JPH05262640A (ja) | 1993-10-12 |
DK0542364T3 (da) | 1996-03-11 |
IL103723A0 (en) | 1993-04-04 |
JP3768247B2 (ja) | 2006-04-19 |
CA2082740A1 (en) | 1993-05-14 |
NZ245100A (en) | 1995-06-27 |
CZ337392A3 (en) | 1993-10-13 |
NO924372D0 (no) | 1992-11-12 |
NO924372L (no) | 1993-05-14 |
AU2827292A (en) | 1993-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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