ES2081618T3 - Metodo para diagnosticar anomalias de la coagulacion de la sangre. - Google Patents
Metodo para diagnosticar anomalias de la coagulacion de la sangre.Info
- Publication number
- ES2081618T3 ES2081618T3 ES92913443T ES92913443T ES2081618T3 ES 2081618 T3 ES2081618 T3 ES 2081618T3 ES 92913443 T ES92913443 T ES 92913443T ES 92913443 T ES92913443 T ES 92913443T ES 2081618 T3 ES2081618 T3 ES 2081618T3
- Authority
- ES
- Spain
- Prior art keywords
- conversion
- sample
- rate
- blood coagulation
- diagnosing blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96461—Protein C (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
LA INVENCION SE REFIERE A UN METODO IN VITRO QUE ES PARTICULARMENTE UTIL PARA EL DIAGNOSTICO DE ENFERMEDADES TROMBOEMBOLICAS, TAL COMO LA TROMBOFILIA HEREDITARIA O NO HEREDITARIA, Y PARA DETERMINAR EL RIESGO POR TROMBOSIS A PROPOSITO DE EMBARAZO, TOMA DE PILDORAS ANTICONCEPTIVAS, CIRUGIA, ETC. EL METODO SE CARACTERIZA EN QUE EL SISTEMA DE COAGULACION EN UNA MUESTRA SE ACTIVA TOTAL O PARCIALMENTE DE UN MODO CONOCIDO DE POR SI E INCUBADO CON PROTEINA C ACTIVADA, DESPUES DE LO CUAL SE DETERMINA EL PROCENTAJE DE REACCION DE CONVERSION DE SUSTRATO COMO COAGULACION O CONVERSION DE UN SUSTRATO CROMOGENICO. EL PORCENTAJE DE CONVERSION OBTENIDO SE COMPARA CON LOS VALORES OBTENIDOS PARA MUESTRAS DE PLASMA NORMAL. SI EL PORCENTAJE SE AUMENTA, ESO INDICA QUE EL INDIVIDUO DEL CUAL SE DERIVA LA MUESTRA PUEDE SUFRIR UNA ENFERMEDAD TROMBOEMBOLICA.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9103332 | 1991-11-13 | ||
SE9103332A SE470274B (sv) | 1991-11-13 | 1991-11-13 | Användning av en in vitro-metod för diagnos av blodkoagulationssjukdomar |
US81130391A | 1991-12-20 | 1991-12-20 | |
US811303 | 1991-12-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2081618T3 true ES2081618T3 (es) | 1996-03-16 |
ES2081618T5 ES2081618T5 (es) | 2005-09-01 |
Family
ID=26661244
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92913443T Expired - Lifetime ES2081618T5 (es) | 1991-11-13 | 1992-05-13 | Metodo para diagnosticar anomalias de la coagulacion de la sangre. |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0608235B2 (es) |
JP (1) | JP2562000B2 (es) |
AT (1) | ATE132909T1 (es) |
CA (1) | CA2119761C (es) |
DE (2) | DE69207607T3 (es) |
DK (1) | DK0608235T4 (es) |
ES (1) | ES2081618T5 (es) |
GR (1) | GR3018646T3 (es) |
HK (1) | HK31697A (es) |
WO (1) | WO1993010261A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4229933A1 (de) * | 1992-09-08 | 1994-03-10 | Max Planck Gesellschaft | Verfahren zur Bestimmung von Thrombose verursachenden Lupus-anticoagulant-Antikörpern |
JPH08506181A (ja) * | 1993-01-29 | 1996-07-02 | ダールベック,ビョルン | 新規抗凝固性補助因子活性 |
US5472852A (en) * | 1993-09-15 | 1995-12-05 | Oklahoma Medical Research Foundation | Assay for detection of selective Protein C inhibition by patients |
EP0656424B1 (de) * | 1993-12-03 | 2002-02-06 | Baxter Aktiengesellschaft | Test zur Bestimmung der Empfindlichkeit gegenüber aktiviertem Protein C |
CA2159907C (en) * | 1994-02-14 | 2006-12-12 | Rogier Maria Bertina | A method for screening for the presence of a genetic defect associated with thrombosis and/or poor anticoagulant response to activated protein c |
DE4418635C2 (de) * | 1994-05-27 | 1997-07-24 | Immuno Ag | Pharmazeutische Zusammensetzung zur Vorbeugung und Behandlung von Blutgerinnungsstörungen |
AUPM731394A0 (en) * | 1994-08-05 | 1994-09-01 | Life Therapeutics Limited | Improved activated protein c resistance test |
EP0711838B2 (de) † | 1994-11-10 | 2007-06-20 | Dade Behring Marburg GmbH | Verfahren zum spezifischen Nachweis eines aktivierten Gerinnungsfaktors V mit einer erhöhten Stabilität gegenüber aktiviertem Protein C |
US5705395A (en) * | 1994-11-14 | 1998-01-06 | The Scripps Research Institute | Method for diagnosis of thrombotic disorders |
US6867045B1 (en) | 1994-11-14 | 2005-03-15 | The Scripps Research Institute | Method for diagnosis of thrombotic disorders |
EP0718628B2 (en) † | 1994-12-23 | 2005-02-23 | Diagnostic Reagents Limited | Method for diagnosis of blood coagulation disorders |
US5874256A (en) * | 1995-06-06 | 1999-02-23 | Rijks Universiteit Leiden | Method for diagnosing an increased risk for thrombosis or a genetic defect causing thrombosis and kit for use with the same |
US5780255A (en) * | 1995-06-09 | 1998-07-14 | Instrumentation Laboratory, S.P.A. | Protein C pathway screening test |
AT403289B (de) * | 1996-01-30 | 1997-12-29 | Immuno Ag | Verfahren zur herstellung eines standardisierten plasmapools für diagnostische zwecke |
US6379975B1 (en) | 1996-11-27 | 2002-04-30 | T.A.C. Thrombosis And Coagulation Aktiebolag | Methods and reagents for determining protein S |
FR2764389B1 (fr) * | 1997-06-06 | 1999-08-06 | Stago Diagnostica | Utilisation de venin de crotalus viridis helleri, procede et necessaire pour la determination de la reactivite de la proteine c activee |
DE19724239A1 (de) * | 1997-06-09 | 1998-12-10 | Max Planck Gesellschaft | Dysprothrombinämie |
US6743596B1 (en) | 2000-10-27 | 2004-06-01 | Biomerieux, Inc. | Method of determining global coagulability hemostatic potential |
US6855509B2 (en) | 2000-12-19 | 2005-02-15 | Instrumentation Laboratory Company | Protein S functional assay and kit therefor |
US7696309B2 (en) * | 2006-10-23 | 2010-04-13 | The Brigham And Women's Hospital, Inc. | Protease resistant mutants of stromal cell derived factor-1 in the repair of tissue damage |
US10662234B2 (en) | 2011-06-07 | 2020-05-26 | Mesoblast International Sàrl | Methods for repairing tissue damage using protease-resistant mutants of stromal cell derived factor-1 |
RU2518247C2 (ru) * | 2011-07-26 | 2014-06-10 | Общество с ограниченной ответственностью "ГемаКор Лабс" (ООО "ГемаКор Лабс") | Способ определения пространственно-временного распределения активности протеолитического фермента в гетерогенной системе, устройство для реализации указанного способа и способ диагностики нарушений системы гемостаза по изменению пространственно-временного распределения активности протеолитического фермента в гетерогенной системе |
WO2016123163A2 (en) | 2015-01-27 | 2016-08-04 | Kardiatonos, Inc. | Biomarkers of vascular disease |
RU2752776C1 (ru) * | 2020-12-16 | 2021-08-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Алтайский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Способ определения длительности тромбопрофилактики низкомолекулярным гепарином после абдоминального родоразрешения у носителей мутации Лейден, генотип F5 G1691A |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991001383A1 (en) * | 1989-07-14 | 1991-02-07 | Michigan State University | Method for diagnosing blood clotting disorders |
US5051357A (en) * | 1989-07-14 | 1991-09-24 | Board Of Trustees Operating Michigan State University | Method and assay using inactivation of factors Va and VIIIa by activated Protein C to diagnose thrombic disease or assay for Protein C and kit therefor |
SE464135B (sv) * | 1989-07-14 | 1991-03-11 | Kabivitrum Ab | Foerfarande foer bestaemning av funktionell aktivitet av fritt protein s eller protein c i ett plasmaprov |
US5169786A (en) * | 1989-12-19 | 1992-12-08 | Ortho Diagnostic Systems, Inc. | Method of determining levels of extrinsic and intrinsic clotting factors and protein c |
EP0711838B2 (de) † | 1994-11-10 | 2007-06-20 | Dade Behring Marburg GmbH | Verfahren zum spezifischen Nachweis eines aktivierten Gerinnungsfaktors V mit einer erhöhten Stabilität gegenüber aktiviertem Protein C |
US5705395A (en) † | 1994-11-14 | 1998-01-06 | The Scripps Research Institute | Method for diagnosis of thrombotic disorders |
-
1992
- 1992-05-13 WO PCT/SE1992/000310 patent/WO1993010261A1/en active IP Right Grant
- 1992-05-13 EP EP92913443A patent/EP0608235B2/en not_active Expired - Lifetime
- 1992-05-13 ES ES92913443T patent/ES2081618T5/es not_active Expired - Lifetime
- 1992-05-13 DK DK92913443T patent/DK0608235T4/da active
- 1992-05-13 AT AT92913443T patent/ATE132909T1/de not_active IP Right Cessation
- 1992-05-13 CA CA002119761A patent/CA2119761C/en not_active Expired - Lifetime
- 1992-05-13 DE DE69207607T patent/DE69207607T3/de not_active Expired - Lifetime
- 1992-05-13 JP JP5509186A patent/JP2562000B2/ja not_active Expired - Lifetime
- 1992-05-13 DE DE0608235T patent/DE608235T1/de active Pending
-
1996
- 1996-01-11 GR GR950403711T patent/GR3018646T3/el unknown
-
1997
- 1997-03-13 HK HK31697A patent/HK31697A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0608235A1 (en) | 1994-08-03 |
JPH07501217A (ja) | 1995-02-09 |
CA2119761C (en) | 1997-12-16 |
EP0608235B1 (en) | 1996-01-10 |
AU666484B2 (en) | 1996-02-15 |
EP0608235B2 (en) | 2005-05-04 |
DE69207607T2 (de) | 1996-06-20 |
ATE132909T1 (de) | 1996-01-15 |
DE69207607T3 (de) | 2006-07-06 |
AU2198092A (en) | 1993-06-15 |
GR3018646T3 (en) | 1996-04-30 |
DK0608235T4 (da) | 2005-05-30 |
DE69207607D1 (de) | 1996-02-22 |
JP2562000B2 (ja) | 1996-12-11 |
HK31697A (en) | 1997-03-21 |
WO1993010261A1 (en) | 1993-05-27 |
ES2081618T5 (es) | 2005-09-01 |
DK0608235T3 (da) | 1996-02-12 |
DE608235T1 (de) | 1994-12-22 |
CA2119761A1 (en) | 1993-05-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2081618T3 (es) | Metodo para diagnosticar anomalias de la coagulacion de la sangre. | |
CA2282746A1 (en) | Prediction of coronary artery disease | |
DE69814639D1 (de) | Nicht-invasive pränatale diagnose | |
ATE63168T1 (de) | Kontroll- bzw. eichserum fuer die lipiddiagnostik. | |
DK0791175T3 (da) | Separationsmidler udnyttende vakuum, til legemsvæsker | |
DK0868519T3 (da) | Diagnose og behandling af AUR-1- og/eller AUR-2-relaterede lidelser | |
ES2151880T3 (es) | Antagonistas de proteina de coagulacion de la sangre y sus utilizaciones. | |
KR930022086A (ko) | 아밀로이드 전구체 단백질의 단백질가수분해에 근거한 알츠하이머병(Alzheimer's disease)의 진단분석 | |
CA2346055A1 (en) | Method and device for predicting physiological values | |
ES2058908T3 (es) | Procedimiento para la separacion y purificacion de sialil-transferasas. | |
ES516496A0 (es) | "procedimiento para la determinacion de hemoglobina glucosilada". | |
DE3783966D1 (de) | Reagens zur pruefung von periodentalen erkrankungen. | |
FR2737732B1 (fr) | Test co-dominant de diagnostic genetique | |
WO2004016065A3 (es) | SISTEMA Y PROCEDIMIENTO INMUNOCROMATOGRÁFICO PARA LA INDENTIFICACIÓN SIMULTÁNEA DE ANTICUERPOS FRENTE A AGA Y t-TG, Y SU USO EN EL DIAGNOSTICO DE ENFERMEDAD CELIACA | |
CA2328955A1 (en) | Fetal testing for prediction of low birth weight | |
WO2001065262A3 (en) | Reagents and methods useful for detecting diseases of the breast | |
CA2332310A1 (en) | Antibody against protein tyrosine phosphatase intracellular domains | |
ES2099876T3 (es) | Procedimiento para la determinacion de anticuerpos de lupus anticoagulante que provocan trombosis. | |
RU2141667C1 (ru) | Способ диагностики эрозивного гастродуоденита и язвенной болезни у детей | |
SU1435992A1 (ru) | Способ гистологической диагностики синдрома дессеминированного внутрисосудистого свертывани крови | |
WO2001086292A3 (en) | Ipg assay | |
AU5736899A (en) | A mutant of tissue factor pathway inhibitor, dna sequence and use for detecting thrombotic disorders | |
KR880701886A (ko) | 췌장효소원의 유리활성화 펩티드의 면역검정에 의한 질병의 진단, 위중도 예견, 및 모니터링 | |
WO1999064584A3 (de) | Protein zur regulation von apoptose | |
WO2002044723A3 (en) | Method for diagnosing a predisposition of psychosis in a progeny |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 608235 Country of ref document: ES |