ES2081192T3 - Inhibidor de timidina quinasa viral del herpes simple. - Google Patents
Inhibidor de timidina quinasa viral del herpes simple.Info
- Publication number
- ES2081192T3 ES2081192T3 ES93402128T ES93402128T ES2081192T3 ES 2081192 T3 ES2081192 T3 ES 2081192T3 ES 93402128 T ES93402128 T ES 93402128T ES 93402128 T ES93402128 T ES 93402128T ES 2081192 T3 ES2081192 T3 ES 2081192T3
- Authority
- ES
- Spain
- Prior art keywords
- thymidine kinase
- inhibitor
- thymid
- thymin
- kinase inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
INHIBIDOR DE TIMIDINA QUINASA DE FORMULA I EN LA CUAL R ES ALQUILO C1-6 O AR(CH2)N-, EN DONDE AR REPRESENTA FENILO OPCIONALMENTE SUSTITUIDO CON DE UNO A CINCO HALOGENOS IGUALES O DIFERENTES, ALQUILO C1-6 O ALQUILOOXILO C1-6; Y N ES IGUAL A DE UNO A SEIS. UN ASPECTO ADICIONAL DE LA PRESENTE INVENCION ES EL USO DE TALES INHIBIDORES DE TIMIDINA QUINASA EN LA FABRICACION DE UNA COMPOSICION PARA INHIBIR TIMIDINA QUINASA VIRICA. ADEMAS OTRO ASPECTO DE LA INVENCION ES RELATIVA AL USO DE TAL INHIBIDOR DE TIMIDINA QUINASA EN LA FABRICACION DE UN MEDICAMENTO PARA TRATAR INFECCIONES DE HERPES SIMPLE VIRICO EN MAMIFEROS. ADEMAS OTRO ASPECTO DE LA INVENCION PROVEE UNA FORMULACION FARMACEUTICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/939,232 US5306722A (en) | 1992-09-02 | 1992-09-02 | Thymidine derivatives and therapeutic method of use |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2081192T3 true ES2081192T3 (es) | 1996-02-16 |
Family
ID=25472788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93402128T Expired - Lifetime ES2081192T3 (es) | 1992-09-02 | 1993-08-31 | Inhibidor de timidina quinasa viral del herpes simple. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5306722A (es) |
EP (1) | EP0586298B1 (es) |
JP (1) | JPH06172349A (es) |
AT (1) | ATE130618T1 (es) |
CA (1) | CA2104895A1 (es) |
DE (1) | DE69300857T2 (es) |
DK (1) | DK0586298T3 (es) |
ES (1) | ES2081192T3 (es) |
GR (1) | GR3019075T3 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5550132A (en) * | 1994-06-22 | 1996-08-27 | University Of North Carolina | Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines |
US5643893A (en) * | 1994-06-22 | 1997-07-01 | Macronex, Inc. | N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE147775C (es) * | 1900-01-01 | |||
JPS5699478A (en) * | 1980-01-11 | 1981-08-10 | Taiho Yakuhin Kogyo Kk | 5-fluorouracil derivative and its preparation |
US4782142A (en) * | 1982-01-05 | 1988-11-01 | The Research Foundation Of State University Of New York | Novel 5-substituted 2-pyrimidinone nucleosides and methods of use |
US4468384A (en) * | 1982-01-05 | 1984-08-28 | The Research Foundation Of State University Of New York | Method for the inhibition of the replication of DNA viruses with 5-substituted 2-pyrimidinone nucleosides |
DK363987A (da) * | 1986-08-08 | 1988-02-09 | Hoffmann La Roche | Pyrimidinderivater |
DK163128C (da) * | 1986-08-12 | 1992-06-15 | Hoffmann La Roche | Pyrimidinnucleosider, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende pyrimidinnucleosiderne og anvendelse af pyrimidinnucleosiderne |
NO170884C (no) * | 1986-08-18 | 1992-12-23 | Hoffmann La Roche | Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater |
US5008252A (en) * | 1987-03-20 | 1991-04-16 | The University Of North Carolina At Chapel Hill | Process for inhibiting herpes simplex virus-specified thymidine kinase |
US4782062A (en) * | 1987-05-11 | 1988-11-01 | Merck & Co., Inc. | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines |
US4863927A (en) * | 1987-05-11 | 1989-09-05 | Merck & Co., Inc. | 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils |
DE68917479D1 (de) * | 1988-02-24 | 1994-09-15 | Inst Rech Chim Biolog | Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha-amino-gruppen, verfahren zur herstellung und arzneimittel daraus. |
US5091375A (en) * | 1988-02-29 | 1992-02-25 | Bayer Ag | Nikkomycin derivatives |
-
1992
- 1992-09-02 US US07/939,232 patent/US5306722A/en not_active Expired - Lifetime
-
1993
- 1993-08-25 JP JP5209783A patent/JPH06172349A/ja active Pending
- 1993-08-26 CA CA002104895A patent/CA2104895A1/en not_active Abandoned
- 1993-08-31 AT AT93402128T patent/ATE130618T1/de not_active IP Right Cessation
- 1993-08-31 EP EP93402128A patent/EP0586298B1/en not_active Expired - Lifetime
- 1993-08-31 ES ES93402128T patent/ES2081192T3/es not_active Expired - Lifetime
- 1993-08-31 DE DE69300857T patent/DE69300857T2/de not_active Expired - Fee Related
- 1993-08-31 DK DK93402128.8T patent/DK0586298T3/da active
-
1996
- 1996-02-22 GR GR960400481T patent/GR3019075T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
JPH06172349A (ja) | 1994-06-21 |
EP0586298A1 (en) | 1994-03-09 |
DK0586298T3 (da) | 1996-03-04 |
EP0586298B1 (en) | 1995-11-22 |
CA2104895A1 (en) | 1994-03-03 |
DE69300857D1 (de) | 1996-01-04 |
ATE130618T1 (de) | 1995-12-15 |
US5306722A (en) | 1994-04-26 |
GR3019075T3 (en) | 1996-05-31 |
DE69300857T2 (de) | 1996-07-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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