DE69300857T2 - Inhibitoren der Thymidinkinase von Herpes Simplex Virus. - Google Patents

Inhibitoren der Thymidinkinase von Herpes Simplex Virus.

Info

Publication number
DE69300857T2
DE69300857T2 DE69300857T DE69300857T DE69300857T2 DE 69300857 T2 DE69300857 T2 DE 69300857T2 DE 69300857 T DE69300857 T DE 69300857T DE 69300857 T DE69300857 T DE 69300857T DE 69300857 T2 DE69300857 T2 DE 69300857T2
Authority
DE
Germany
Prior art keywords
thymidine kinase
herpes simplex
inhibitors
simplex virus
virus thymidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69300857T
Other languages
English (en)
Other versions
DE69300857D1 (de
Inventor
Choung Un Kim
Bing Yu Luh
Peter F Misco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE69300857D1 publication Critical patent/DE69300857D1/de
Application granted granted Critical
Publication of DE69300857T2 publication Critical patent/DE69300857T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69300857T 1992-09-02 1993-08-31 Inhibitoren der Thymidinkinase von Herpes Simplex Virus. Expired - Fee Related DE69300857T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/939,232 US5306722A (en) 1992-09-02 1992-09-02 Thymidine derivatives and therapeutic method of use

Publications (2)

Publication Number Publication Date
DE69300857D1 DE69300857D1 (de) 1996-01-04
DE69300857T2 true DE69300857T2 (de) 1996-07-04

Family

ID=25472788

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69300857T Expired - Fee Related DE69300857T2 (de) 1992-09-02 1993-08-31 Inhibitoren der Thymidinkinase von Herpes Simplex Virus.

Country Status (9)

Country Link
US (1) US5306722A (de)
EP (1) EP0586298B1 (de)
JP (1) JPH06172349A (de)
AT (1) ATE130618T1 (de)
CA (1) CA2104895A1 (de)
DE (1) DE69300857T2 (de)
DK (1) DK0586298T3 (de)
ES (1) ES2081192T3 (de)
GR (1) GR3019075T3 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550132A (en) * 1994-06-22 1996-08-27 University Of North Carolina Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines
US5643893A (en) * 1994-06-22 1997-07-01 Macronex, Inc. N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE147775C (de) * 1900-01-01
JPS5699478A (en) * 1980-01-11 1981-08-10 Taiho Yakuhin Kogyo Kk 5-fluorouracil derivative and its preparation
US4782142A (en) * 1982-01-05 1988-11-01 The Research Foundation Of State University Of New York Novel 5-substituted 2-pyrimidinone nucleosides and methods of use
US4468384A (en) * 1982-01-05 1984-08-28 The Research Foundation Of State University Of New York Method for the inhibition of the replication of DNA viruses with 5-substituted 2-pyrimidinone nucleosides
DK363987A (da) * 1986-08-08 1988-02-09 Hoffmann La Roche Pyrimidinderivater
DK163128C (da) * 1986-08-12 1992-06-15 Hoffmann La Roche Pyrimidinnucleosider, fremgangsmaade til fremstilling deraf, farmaceutiske praeparater indeholdende pyrimidinnucleosiderne og anvendelse af pyrimidinnucleosiderne
NO170884C (no) * 1986-08-18 1992-12-23 Hoffmann La Roche Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater
US5008252A (en) * 1987-03-20 1991-04-16 The University Of North Carolina At Chapel Hill Process for inhibiting herpes simplex virus-specified thymidine kinase
US4782062A (en) * 1987-05-11 1988-11-01 Merck & Co., Inc. 9-(2-hydroxymethyl)cycloalkylmethyl) guanines
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
DE68917479D1 (de) * 1988-02-24 1994-09-15 Inst Rech Chim Biolog Derivate von deoxy-2'-uridin substituiert in der 5, 3' oder 5' stellung durch acylierte alpha-amino-gruppen, verfahren zur herstellung und arzneimittel daraus.
US5091375A (en) * 1988-02-29 1992-02-25 Bayer Ag Nikkomycin derivatives

Also Published As

Publication number Publication date
JPH06172349A (ja) 1994-06-21
EP0586298A1 (de) 1994-03-09
DK0586298T3 (da) 1996-03-04
EP0586298B1 (de) 1995-11-22
CA2104895A1 (en) 1994-03-03
DE69300857D1 (de) 1996-01-04
ATE130618T1 (de) 1995-12-15
ES2081192T3 (es) 1996-02-16
US5306722A (en) 1994-04-26
GR3019075T3 (en) 1996-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee