ES2080114T3 - Procedimiento para preparar un factor inhibidor de la metastasis. - Google Patents

Procedimiento para preparar un factor inhibidor de la metastasis.

Info

Publication number
ES2080114T3
ES2080114T3 ES90305459T ES90305459T ES2080114T3 ES 2080114 T3 ES2080114 T3 ES 2080114T3 ES 90305459 T ES90305459 T ES 90305459T ES 90305459 T ES90305459 T ES 90305459T ES 2080114 T3 ES2080114 T3 ES 2080114T3
Authority
ES
Spain
Prior art keywords
mif
metastasis
preparing
procedure
inhibiting factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90305459T
Other languages
English (en)
Inventor
Masashi Kurimoto
Ryuichi Motoda
Kanso Iwaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hayashibara Seibutsu Kagaku Kenkyujo KK
Original Assignee
Hayashibara Seibutsu Kagaku Kenkyujo KK
Hayashibara Biochemical Laboratories Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hayashibara Seibutsu Kagaku Kenkyujo KK, Hayashibara Biochemical Laboratories Co Ltd filed Critical Hayashibara Seibutsu Kagaku Kenkyujo KK
Application granted granted Critical
Publication of ES2080114T3 publication Critical patent/ES2080114T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LAS CELULAS HEMATOPOYETICAS HUMANAS PRODUCEN EL FACTOR INHIBITORIO DE LA METASTASIS (MIF). EL MIF PRESENTA UNA NOTABLE ACTIVIDAD INHIBITORIA DE LA METASTASIS EN ENFERMEDADES VIRICAS E INMUNOPATIAS, ASI COMO, EN TUMORES MALIGNOS. LAS CELULAS HEMATOPOYETICAS HUMANAS PRODUCTORAS DEL MIF PROLIFERAN FACILMENTE MEDIANTE CULTIVOS DE TEJIDOS IN VITRO, ESTOS CULTIVOS SE HACEN EN ANIMALES DE SANGRE CALIENTE NO HUMANOS. LAS CELULAS T PRESENTAN UNA ALTA PRODUCCION DE MIF. LOS MITOGENES AUMENTAN LA PRODUCCION DE MIF CUANDO SE USA UN INDUCTOR DE MIF.
ES90305459T 1989-05-22 1990-05-21 Procedimiento para preparar un factor inhibidor de la metastasis. Expired - Lifetime ES2080114T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1128362A JP2926409B2 (ja) 1989-05-22 1989-05-22 癌転移抑制因子の製造方法

Publications (1)

Publication Number Publication Date
ES2080114T3 true ES2080114T3 (es) 1996-02-01

Family

ID=14982946

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90305459T Expired - Lifetime ES2080114T3 (es) 1989-05-22 1990-05-21 Procedimiento para preparar un factor inhibidor de la metastasis.

Country Status (11)

Country Link
US (1) US5126148A (es)
EP (1) EP0401997B1 (es)
JP (1) JP2926409B2 (es)
KR (1) KR0157227B1 (es)
AT (1) ATE127527T1 (es)
CA (1) CA2017279A1 (es)
DE (1) DE69022121T2 (es)
DK (1) DK0401997T3 (es)
ES (1) ES2080114T3 (es)
GR (1) GR3018004T3 (es)
RU (1) RU2070046C1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3439490B2 (ja) * 1992-09-28 2003-08-25 株式会社林原生物化学研究所 蛋白質とその蛋白質をコードするｄｎａ並びにその蛋白質の製造方法
JPH1080270A (ja) * 1996-07-19 1998-03-31 Hayashibara Biochem Lab Inc ポリペプチドをプロセッシングする酵素

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4785077A (en) * 1986-05-05 1988-11-15 Scripps Clinic And Research Foundation Substantially pure cytotoxicity triggering factor

Also Published As

Publication number Publication date
EP0401997A1 (en) 1990-12-12
GR3018004T3 (en) 1996-02-29
CA2017279A1 (en) 1990-11-22
EP0401997B1 (en) 1995-09-06
DE69022121T2 (de) 1996-04-04
ATE127527T1 (de) 1995-09-15
US5126148A (en) 1992-06-30
JPH02308799A (ja) 1990-12-21
JP2926409B2 (ja) 1999-07-28
KR0157227B1 (ko) 1998-10-15
DE69022121D1 (de) 1995-10-12
RU2070046C1 (ru) 1996-12-10
DK0401997T3 (da) 1995-10-16
KR900018379A (ko) 1990-12-21

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