ES2079172T3 - Nuevo procedimiento de cristalizacion de sustancias organicas de origen esteroideo y compuestos asi obtenidos. - Google Patents
Nuevo procedimiento de cristalizacion de sustancias organicas de origen esteroideo y compuestos asi obtenidos.Info
- Publication number
- ES2079172T3 ES2079172T3 ES92900237T ES92900237T ES2079172T3 ES 2079172 T3 ES2079172 T3 ES 2079172T3 ES 92900237 T ES92900237 T ES 92900237T ES 92900237 T ES92900237 T ES 92900237T ES 2079172 T3 ES2079172 T3 ES 2079172T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- crystallization
- steroid
- origin
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0025—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0074—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0077—Ethers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
LA PRESENTE INVENCION SE REFIERE A UN NUEVO PROCESO DE CRISTALIZACION DE SUSTANCIAS ORGANICAS Y EN PARTICULAR ESTEROIDIANAS. LA PRESENTE INVENCION TIENE ESPECIFICAMENTE COMO OBJETO UN PROCESO DE CRISTALIZACION QUE PERMITE SIN OPERACION MECANICA OBTENER UNA CLASE GRANULOMETRICA HOMOGENEA PREDETERMINABLE, QUE CONSISTE EN QUE SE DISUELVE UNA SUSTANCIA EN UNA MEZCLA TERNARIA FORMADA POR UN SOLVENTE LIPOFILO, POR UN SOLVENTE HIDROFILO Y POR UN AGENTE TENSIOACTIVO A UNA TEMPERATURA CERCANA A LA EBULLICION DESPUES SE DEJA QUE LA MEZCLA VUELVA A UNA TEMPERATURA EN LA QUE LA CRISTALIZACION SE INICIA Y SEPARA LOS CRISTALES FORMADOS. PRODUCCION DE PRINCIPIOS ACTIVOS FARMACEUTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9013981A FR2668945B1 (fr) | 1990-11-12 | 1990-11-12 | Nouveau procede de cristallisation des substances organiques et les composes ainsi obtenus. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2079172T3 true ES2079172T3 (es) | 1996-01-01 |
Family
ID=9402062
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92900237T Expired - Lifetime ES2079172T3 (es) | 1990-11-12 | 1991-11-12 | Nuevo procedimiento de cristalizacion de sustancias organicas de origen esteroideo y compuestos asi obtenidos. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5266712A (es) |
EP (1) | EP0510167B1 (es) |
JP (1) | JP3281954B2 (es) |
KR (1) | KR100196895B1 (es) |
AT (1) | ATE126806T1 (es) |
BR (1) | BR9106012A (es) |
CA (1) | CA2073760C (es) |
DE (1) | DE69112379T2 (es) |
DK (1) | DK0510167T3 (es) |
ES (1) | ES2079172T3 (es) |
FI (1) | FI111545B (es) |
FR (1) | FR2668945B1 (es) |
GR (1) | GR3018117T3 (es) |
HU (1) | HU212780B (es) |
LV (1) | LV11183B (es) |
RU (1) | RU2126013C1 (es) |
WO (1) | WO1992008730A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2776191B1 (fr) * | 1998-03-23 | 2002-05-31 | Theramex | Composition hormonale topique a effet systemique |
US6432936B1 (en) * | 1999-01-20 | 2002-08-13 | Wisconsin Alumni Research Foundation | Crystalline 1α-hydroxyvitamin D2 and method of purification thereof |
US7198801B2 (en) | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
BRPI0116793B8 (pt) * | 2000-12-14 | 2021-05-25 | Johnson & Johnson | produtos de hormônio de esteróide e métodos para prepará-los |
DE10218107A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Steroiden, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
DE10218106A1 (de) * | 2002-04-23 | 2003-11-20 | Jenapharm Gmbh | Verfahren zum Herstellen von Kristallen von Arzneimittelwirkstoffen, danach erhältliche Kristalle und deren Verwendung in pharmazeutischen Formulierungen |
MY143936A (en) | 2003-03-27 | 2011-07-29 | Nycomed Gmbh | Process for preparing crystalline ciclesonide with defined particle size |
PL1670433T3 (pl) | 2003-10-10 | 2013-03-29 | Ferring Bv | Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze |
CA2548281C (en) * | 2003-12-09 | 2013-11-12 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
US20050192264A1 (en) * | 2004-02-04 | 2005-09-01 | Penfold Philip L. | Slow release steroid composition |
US20060058276A1 (en) * | 2004-07-15 | 2006-03-16 | Oded Friedman | Processes for the preparation and purification of rocuronium bromide |
WO2007124250A2 (en) | 2006-04-21 | 2007-11-01 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
WO2006125642A1 (en) | 2005-05-27 | 2006-11-30 | Antares Pharma Ipl Ag | Methods and apparatus for transdermal or transmucosal application of testosterone |
EP1931682A2 (en) * | 2006-08-03 | 2008-06-18 | Teva Pharmaceutical Industries Ltd. | Process for preparing clopidogrel bisulphate |
CN101961311B (zh) * | 2010-09-21 | 2012-11-21 | 中山大学 | 一种5α-雄甾(烷)-3β,5,6β-三醇注射剂及其制备方法 |
BR112014031914B1 (pt) * | 2012-06-18 | 2021-12-14 | Therapeuticsmd, Inc | Formulação farmacêutica encapsulada para liberação intravaginal compreendendo estradiol e uso da mesma para o tratamento de atrofia vulvovaginal e de um sistoma associado, bem como de um estado urinário deficiente em estrogênio |
CN112871079B (zh) * | 2021-01-27 | 2023-05-16 | 丽江映华生物药业有限公司 | 醋酸诺美孕酮微粒的制备方法及制备装置 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2096744A (en) * | 1932-10-27 | 1937-10-26 | Schering Corp | Hydrogenation products of follicle hormones and method of producing same |
US2361847A (en) * | 1937-09-04 | 1944-10-31 | Schering Corp | Aromatization of steroid compounds and more especially to the production of estrone-and estradiollike compounds and of their derivatives from delta 1, 2, 4, 5-androstadienol-17-one-3 |
US2897216A (en) * | 1954-11-01 | 1959-07-28 | Schering Corp | Process for the preparation of steroidal dienes and intermediates obtained thereby |
US3053865A (en) * | 1958-03-19 | 1962-09-11 | Merck & Co Inc | Novel 16-alkyl and 16-alkylene steroids and processes |
US3007923A (en) * | 1959-01-22 | 1961-11-07 | Lab Francais Chimiotherapie | Process for the fluorination of 9beta, 11beta-epoxy and 5alpha, 6alpha-epoxy steroids |
DE2323812A1 (de) * | 1973-05-11 | 1974-11-28 | Jenapharm Veb | Verfahren zur herstellung von kohlensaeurederivaten der oestranreihe |
GB1515284A (en) * | 1974-05-21 | 1978-06-21 | Gastaud J | Pharmaceutical compositions containing progestogens derived from the 17-alpha-hydroxy-19-nor-progesterone series |
-
1990
- 1990-11-12 FR FR9013981A patent/FR2668945B1/fr not_active Expired - Fee Related
-
1991
- 1991-11-12 JP JP50041592A patent/JP3281954B2/ja not_active Expired - Lifetime
- 1991-11-12 KR KR1019920701658A patent/KR100196895B1/ko not_active IP Right Cessation
- 1991-11-12 CA CA002073760A patent/CA2073760C/fr not_active Expired - Lifetime
- 1991-11-12 DE DE69112379T patent/DE69112379T2/de not_active Expired - Lifetime
- 1991-11-12 WO PCT/FR1991/000888 patent/WO1992008730A1/fr active IP Right Grant
- 1991-11-12 HU HU9202608A patent/HU212780B/hu unknown
- 1991-11-12 DK DK92900237.6T patent/DK0510167T3/da active
- 1991-11-12 EP EP92900237A patent/EP0510167B1/fr not_active Expired - Lifetime
- 1991-11-12 RU SU5052919A patent/RU2126013C1/ru active
- 1991-11-12 US US07/910,284 patent/US5266712A/en not_active Expired - Lifetime
- 1991-11-12 BR BR919106012A patent/BR9106012A/pt not_active Application Discontinuation
- 1991-11-12 AT AT92900237T patent/ATE126806T1/de not_active IP Right Cessation
- 1991-11-12 ES ES92900237T patent/ES2079172T3/es not_active Expired - Lifetime
-
1992
- 1992-07-10 FI FI923188A patent/FI111545B/fi not_active IP Right Cessation
-
1995
- 1995-11-14 LV LVP-95-341A patent/LV11183B/lv unknown
- 1995-11-20 GR GR950403233T patent/GR3018117T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
FI923188A0 (fi) | 1992-07-10 |
WO1992008730A1 (fr) | 1992-05-29 |
DE69112379D1 (de) | 1995-09-28 |
FI111545B (fi) | 2003-08-15 |
JPH05503305A (ja) | 1993-06-03 |
CA2073760C (fr) | 2003-09-23 |
LV11183A (lv) | 1996-04-20 |
HU212780B (en) | 1996-11-28 |
KR100196895B1 (ko) | 1999-06-15 |
EP0510167B1 (fr) | 1995-08-23 |
FR2668945A1 (fr) | 1992-05-15 |
BR9106012A (pt) | 1993-01-05 |
GR3018117T3 (en) | 1996-02-29 |
ATE126806T1 (de) | 1995-09-15 |
RU2126013C1 (ru) | 1999-02-10 |
JP3281954B2 (ja) | 2002-05-13 |
HUT61319A (en) | 1992-12-28 |
CA2073760A1 (fr) | 1992-05-13 |
EP0510167A1 (fr) | 1992-10-28 |
FI923188A (fi) | 1992-07-10 |
LV11183B (en) | 1996-10-20 |
DK0510167T3 (da) | 1996-01-02 |
DE69112379T2 (de) | 1996-03-28 |
HU9202608D0 (en) | 1992-10-28 |
US5266712A (en) | 1993-11-30 |
FR2668945B1 (fr) | 1993-02-19 |
KR927003617A (ko) | 1992-12-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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