ES2076837T3 - Dispositivo osmotico con activacion retardada de entrega de farmacos. - Google Patents
Dispositivo osmotico con activacion retardada de entrega de farmacos.Info
- Publication number
- ES2076837T3 ES2076837T3 ES93902985T ES93902985T ES2076837T3 ES 2076837 T3 ES2076837 T3 ES 2076837T3 ES 93902985 T ES93902985 T ES 93902985T ES 93902985 T ES93902985 T ES 93902985T ES 2076837 T3 ES2076837 T3 ES 2076837T3
- Authority
- ES
- Spain
- Prior art keywords
- drug delivery
- distribution
- osmotic device
- delayed activation
- period
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000004913 activation Effects 0.000 title abstract 2
- 230000003111 delayed effect Effects 0.000 title abstract 2
- 238000012377 drug delivery Methods 0.000 title 1
- 230000003204 osmotic effect Effects 0.000 title 1
- 239000012530 fluid Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000006096 absorbing agent Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- External Artificial Organs (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
LA PRESENTE INVENCION ESTA DIRIGIDA A UN DISPOSITIVO (1) ABSORBEDOR DE FLUIDO DE DISTRIBUCION DE MEDICAMENTO QUE ES UTIL PARA LA DISTRIBUCION INICIAL RETARDADA DE UNA FORMULACION DE AGENTE ACTIVO (16) PARA USO EN UN ENTORNO FLUIDO, SIENDO EL PERIODO INICIAL DE RETARDO PARA EL COMIENZO O LA ACTIVACION DE UNA DURACION TEMPORAL PREDERTERMINADA. LA DISTRIBUCION DE LA FORMULACION (169 DESDE EL DISPOSITIVO APLICADOR (1) SE CONTINUA, UNA VEZ COMENZADA, A LO LARGO DE UN PERIODO PROLONGADO DE TIEMPO PREDETERMINADO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/819,417 US5223265A (en) | 1992-01-10 | 1992-01-10 | Osmotic device with delayed activation of drug delivery |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2076837T3 true ES2076837T3 (es) | 1995-11-01 |
Family
ID=25228098
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES93902985T Expired - Lifetime ES2076837T3 (es) | 1992-01-10 | 1993-01-08 | Dispositivo osmotico con activacion retardada de entrega de farmacos. |
Country Status (16)
Country | Link |
---|---|
US (2) | US5223265A (es) |
EP (1) | EP0620729B1 (es) |
JP (1) | JP3514756B2 (es) |
KR (1) | KR100246157B1 (es) |
AT (1) | ATE127338T1 (es) |
AU (1) | AU659285B2 (es) |
CA (1) | CA2124829C (es) |
DE (1) | DE69300451T2 (es) |
DK (1) | DK0620729T3 (es) |
ES (1) | ES2076837T3 (es) |
FI (1) | FI943280A0 (es) |
MX (1) | MX9300101A (es) |
NO (1) | NO942525D0 (es) |
NZ (1) | NZ246796A (es) |
WO (1) | WO1993013759A1 (es) |
ZA (1) | ZA93133B (es) |
Families Citing this family (74)
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US5728088A (en) * | 1988-12-13 | 1998-03-17 | Alza Corporation | Osmotic system for delivery of fluid-sensitive somatotropins to bovine animals |
WO1994014479A1 (en) * | 1992-12-28 | 1994-07-07 | Bausch & Lomb Incorporated | Controlled release composition for active substances into an aqueous medium |
US5290240A (en) * | 1993-02-03 | 1994-03-01 | Pharmetrix Corporation | Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid |
US5540665A (en) * | 1994-01-31 | 1996-07-30 | Alza Corporation | Gas driven dispensing device and gas generating engine therefor |
US5651979A (en) * | 1995-03-30 | 1997-07-29 | Gel Sciences, Inc. | Apparatus and method for delivering a biologically active compound into a biological environment |
US5817335A (en) * | 1995-05-26 | 1998-10-06 | Alza Corporation | Osmotic device with high drug loading and delayed activation of drug delivery |
ES2179946T3 (es) * | 1995-06-02 | 2003-02-01 | Alza Corp | Dispositivo osmotico de activacion retardada para la administracion de un medicamento y liberacion completa del medicamento. |
US5800422A (en) * | 1995-06-02 | 1998-09-01 | Alza Corporation | Osmotic device with delayed activation of drug delivery and complete drug release |
US5904935A (en) * | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
KR0124764Y1 (ko) * | 1995-09-23 | 1998-09-15 | 양주환 | 의약 및 식품용 하드 공 캅셀 |
US5922736A (en) * | 1995-12-04 | 1999-07-13 | Celegene Corporation | Chronic, bolus administration of D-threo methylphenidate |
US5837284A (en) | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
US6486177B2 (en) * | 1995-12-04 | 2002-11-26 | Celgene Corporation | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate |
US5902605A (en) * | 1996-04-18 | 1999-05-11 | Alza Corporation | Drug delivery device with minimal residual drug retention |
AU3590497A (en) * | 1996-07-15 | 1998-02-09 | Alza Corporation | Interlocking osmotic device |
US6962997B1 (en) * | 1997-05-22 | 2005-11-08 | Celgene Corporation | Process and intermediates for resolving piperidyl acetamide steroisomers |
US6994851B1 (en) | 1997-07-10 | 2006-02-07 | Mannkind Corporation | Method of inducing a CTL response |
US6977074B2 (en) * | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
MY125849A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
AU1828599A (en) * | 1997-12-29 | 1999-07-19 | Alza Corporation | Osmotic delivery system with membrane plug retention mechanism |
PT1736145E (pt) * | 1997-12-30 | 2012-03-16 | Intarcia Therapeutics Inc | Sistema de entrega de agente benéfico com obturador de membrana |
AU1937099A (en) | 1997-12-31 | 1999-07-19 | Alza Corporation | Osmotic drug delivery monitoring system and method |
DE19835346A1 (de) * | 1998-08-05 | 2000-02-10 | Boehringer Ingelheim Pharma | Zweiteilige Kapsel zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
US6551613B1 (en) * | 1998-09-08 | 2003-04-22 | Alza Corporation | Dosage form comprising therapeutic formulation |
US6342249B1 (en) | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
US20030170181A1 (en) * | 1999-04-06 | 2003-09-11 | Midha Kamal K. | Method for preventing abuse of methylphenidate |
US6340476B1 (en) | 1999-04-06 | 2002-01-22 | Armaquest, Inc. | Pharmaceutical dosage form for pulsatile delivery of methylphenidate |
KR100734187B1 (ko) | 1999-12-21 | 2007-07-02 | 알자 코포레이션 | 삼투성 장치용 밸브 |
US6669954B2 (en) | 2000-01-25 | 2003-12-30 | John R. Crison | Controlled release of drugs |
CA2429945A1 (en) * | 2000-11-29 | 2002-06-06 | Durect Corporation | Devices and methods for controlled delivery from a drug delivery device |
US6491684B1 (en) * | 2001-05-22 | 2002-12-10 | Durect Corporation | Fluid delivery device having a water generating electrochemical/chemical pump and associated method |
US20030125714A1 (en) * | 2001-12-18 | 2003-07-03 | Edgren David Emil | Dosage form for time-varying patterns of drug delivery |
IL166023A0 (en) * | 2002-06-28 | 2006-01-15 | Alza Corp | Oral dosage from comprising a liquid active agent formulation and controlling release thereof by an expandable osmotic composition |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
US7485322B2 (en) * | 2002-12-24 | 2009-02-03 | Lek Pharmaceuticals D.D. | Modified release pharmaceutical composition |
CA2534364A1 (en) * | 2003-08-07 | 2005-02-17 | Alveolus Inc. | Therapeutic medical appliance, delivery and method of use |
US20050239830A1 (en) * | 2004-04-26 | 2005-10-27 | Vikram Khetani | Methods of diminishing co-abuse potential |
US20050287212A1 (en) * | 2004-06-28 | 2005-12-29 | Liang-Chang Dong | Oral delivery system comprising a drug/polymer complex |
JP2008510000A (ja) * | 2004-08-19 | 2008-04-03 | アルザ・コーポレーシヨン | 制御放出性ナノ粒子有効薬剤配合物投与剤型品および方法 |
US7350479B2 (en) * | 2004-09-10 | 2008-04-01 | United States Of America As Represented By The Secretary Of The Army | System and method for controlling growth of aquatic plants utilizing bio-eroding means implanted in triploid grass carp |
US20060127421A1 (en) * | 2004-12-09 | 2006-06-15 | Celgene Corporation | Treatment using D-threo methylphenidate |
US20060153844A1 (en) * | 2004-12-29 | 2006-07-13 | Thomas Kundig | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
DE102005001332A1 (de) * | 2005-01-11 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Zweiteilige Kapsel mit Vorverschluss zur Aufnahme von pharmazeutischen Zubereitungen für Pulverinhalatoren |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
AU2006269944A1 (en) * | 2005-07-19 | 2007-01-25 | Inverseon, Inc. | Improved pharmacokinetic profile of beta-adrenergic inverse agonists for the treatment of pulmonary airway diseases |
WO2007062266A2 (en) * | 2005-11-28 | 2007-05-31 | Marinus Pharmaceuticals | Ganaxolone formulations and methods for the making and use thereof |
US7762426B2 (en) * | 2006-03-16 | 2010-07-27 | The Procter & Gamble Company | Seal for dispensing container having dispensing opening |
CN101453982B (zh) | 2006-05-30 | 2011-05-04 | 精达制药公司 | 两件式内部通道渗透递送系统流动调节器 |
WO2008021133A2 (en) | 2006-08-09 | 2008-02-21 | Intarcia Therapeutics, Inc. | Osmotic delivery systems and piston assemblies |
KR20090091321A (ko) | 2006-11-28 | 2009-08-27 | 마리누스 파마슈티컬스 | 나노입자 제형, 이의 제조방법 및 이의 용도 |
EP2157967B1 (en) | 2007-04-23 | 2013-01-16 | Intarcia Therapeutics, Inc | Suspension formulations of insulinotropic peptides and uses thereof |
EP2537506A1 (en) * | 2007-10-15 | 2012-12-26 | Capsugel Belgium NV | Linkers for multipart dosage forms for release of one or more parmaceutical compositions, and the resulting dosage forms |
WO2009050192A1 (en) * | 2007-10-15 | 2009-04-23 | Glaxo Group Limited | Paneled capsule shells for release of pharmaceutical compositions |
US8293159B2 (en) * | 2007-10-15 | 2012-10-23 | Capsugel Belgium | Method and apparatus for manufacturing filled linkers |
EP2240155B1 (en) | 2008-02-13 | 2012-06-06 | Intarcia Therapeutics, Inc | Devices, formulations, and methods for delivery of multiple beneficial agents |
CN104323981B (zh) | 2009-09-28 | 2019-03-12 | 精达制药公司 | 基本稳态药物递送的快速建立和/或终止 |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
RU2622748C2 (ru) * | 2011-10-06 | 2017-06-19 | Байо Кэпсьюл Фармасьютикал Энд Ньютришнал Продактс Проприетери Лимитед | Способ и устройство для изготовления капсулы |
US9456987B2 (en) | 2013-04-03 | 2016-10-04 | Binutra, Inc. | Capsule with internal diaphragm |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
WO2016196851A2 (en) | 2015-06-03 | 2016-12-08 | Intarcia Therapeutics, Inc. | Implant placement and removal systems |
CN108366959A (zh) * | 2015-10-09 | 2018-08-03 | 科姆博盖股份有限公司 | 具有体积可调整的内部隔片的胶囊 |
MX2018014016A (es) | 2016-05-16 | 2019-08-01 | Intarcia Therapeutics Inc | Polipéptidos selectivos del receptor de glucagón y métodos para utilizarlos. |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
EP4233861A3 (en) | 2016-08-11 | 2023-10-11 | Ovid Therapeutics, Inc. | Compositions for treatment of essential tremor |
CN110225762A (zh) | 2017-01-03 | 2019-09-10 | 因塔西亚制药公司 | 包括glp-1受体激动剂的连续施用和药物的共同施用的方法 |
USD933219S1 (en) | 2018-07-13 | 2021-10-12 | Intarcia Therapeutics, Inc. | Implant removal tool and assembly |
US11266662B2 (en) | 2018-12-07 | 2022-03-08 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in prophylaxis and treatment of postpartum depression |
WO2021026124A1 (en) | 2019-08-05 | 2021-02-11 | Marinus Pharmaceuticals, Inc. | Ganaxolone for use in treatment of status epilepticus |
EP4072559A4 (en) | 2019-12-06 | 2023-06-21 | Marinus Pharmaceuticals, Inc. | GANAXOLONE FOR USE IN THE TREATMENT OF TUBEROUS SCLEROSIS COMPLEX |
WO2024075723A1 (ja) * | 2022-10-07 | 2024-04-11 | テルモ株式会社 | 薬剤投与装置 |
Family Cites Families (33)
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US4034756A (en) * | 1971-01-13 | 1977-07-12 | Alza Corporation | Osmotically driven fluid dispenser |
US3732865A (en) * | 1971-01-13 | 1973-05-15 | Alza Corp | Osmotic dispenser |
US3995631A (en) * | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
US3845770A (en) * | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US3916899A (en) * | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
US3995632A (en) * | 1973-05-04 | 1976-12-07 | Alza Corporation | Osmotic dispenser |
US4002173A (en) * | 1974-07-23 | 1977-01-11 | International Paper Company | Diester crosslinked polyglucan hydrogels and reticulated sponges thereof |
GB1478759A (en) * | 1974-11-18 | 1977-07-06 | Alza Corp | Process for forming outlet passageways in pills using a laser |
US4063064A (en) * | 1976-02-23 | 1977-12-13 | Coherent Radiation | Apparatus for tracking moving workpiece by a laser beam |
US4111202A (en) * | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
US4207893A (en) * | 1977-08-29 | 1980-06-17 | Alza Corporation | Device using hydrophilic polymer for delivering drug to biological environment |
US4200098A (en) * | 1978-10-23 | 1980-04-29 | Alza Corporation | Osmotic system with distribution zone for dispensing beneficial agent |
US4285987A (en) * | 1978-10-23 | 1981-08-25 | Alza Corporation | Process for manufacturing device with dispersion zone |
US4265874A (en) * | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
US4320759A (en) * | 1980-04-28 | 1982-03-23 | Alza Corporation | Dispenser with diffuser |
US4327725A (en) * | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
US4449983A (en) * | 1982-03-22 | 1984-05-22 | Alza Corporation | Simultaneous delivery of two drugs from unit delivery device |
US4612008A (en) * | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
US4777049A (en) * | 1983-12-01 | 1988-10-11 | Alza Corporation | Constant release system with pulsed release |
US4595583A (en) * | 1984-03-19 | 1986-06-17 | Alza Corporation | Delivery system controlled administration of beneficial agent to ruminants |
US4601896A (en) * | 1984-03-21 | 1986-07-22 | Mark Nugent | Pharmaceutical capsule compositions and structures for gastric sensitive materials |
US4643731A (en) * | 1985-08-16 | 1987-02-17 | Alza Corporation | Means for providing instant agent from agent dispensing system |
US4955881A (en) * | 1985-08-16 | 1990-09-11 | Alza Corporation | Ruminant dispensing device |
US4874388A (en) * | 1987-06-25 | 1989-10-17 | Alza Corporation | Multi-layer delivery system |
US5023088A (en) * | 1987-06-25 | 1991-06-11 | Alza Corporation | Multi-unit delivery system |
US4872873A (en) * | 1987-12-14 | 1989-10-10 | Merck & Co., Inc. | Controlled release bolus device |
US5034229A (en) * | 1988-12-13 | 1991-07-23 | Alza Corporation | Dispenser for increasing feed conversion of hog |
US4976966A (en) * | 1988-12-29 | 1990-12-11 | Alza Corporation | Delayed release osmotically driven fluid dispenser |
GB8903564D0 (en) * | 1989-02-16 | 1989-04-05 | Rashid Abdul | Drug dispensing device |
US5178866A (en) * | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
US5017381A (en) * | 1990-05-02 | 1991-05-21 | Alza Corporation | Multi-unit pulsatile delivery system |
CA2098992A1 (en) * | 1991-01-30 | 1992-07-31 | Patrick S. L. Wong | Osmotic device for delayed delivery of agent |
-
1992
- 1992-01-10 US US07/819,417 patent/US5223265A/en not_active Expired - Lifetime
-
1993
- 1993-01-08 EP EP93902985A patent/EP0620729B1/en not_active Expired - Lifetime
- 1993-01-08 WO PCT/US1993/000110 patent/WO1993013759A1/en active IP Right Grant
- 1993-01-08 AU AU34368/93A patent/AU659285B2/en not_active Ceased
- 1993-01-08 MX MX9300101A patent/MX9300101A/es not_active IP Right Cessation
- 1993-01-08 DK DK93902985.6T patent/DK0620729T3/da active
- 1993-01-08 ZA ZA93133A patent/ZA93133B/xx unknown
- 1993-01-08 CA CA002124829A patent/CA2124829C/en not_active Expired - Fee Related
- 1993-01-08 NZ NZ246796A patent/NZ246796A/en not_active IP Right Cessation
- 1993-01-08 JP JP51256493A patent/JP3514756B2/ja not_active Expired - Fee Related
- 1993-01-08 KR KR1019940702383A patent/KR100246157B1/ko not_active IP Right Cessation
- 1993-01-08 AT AT93902985T patent/ATE127338T1/de not_active IP Right Cessation
- 1993-01-08 ES ES93902985T patent/ES2076837T3/es not_active Expired - Lifetime
- 1993-01-08 DE DE69300451T patent/DE69300451T2/de not_active Expired - Fee Related
- 1993-01-14 US US08/004,340 patent/US5312390A/en not_active Expired - Lifetime
-
1994
- 1994-07-05 NO NO942525A patent/NO942525D0/no unknown
- 1994-07-08 FI FI943280A patent/FI943280A0/fi not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU3436893A (en) | 1993-08-03 |
CA2124829A1 (en) | 1993-07-22 |
WO1993013759A1 (en) | 1993-07-22 |
ZA93133B (en) | 1993-08-16 |
DE69300451D1 (de) | 1995-10-12 |
JPH07504401A (ja) | 1995-05-18 |
CA2124829C (en) | 2004-03-16 |
EP0620729B1 (en) | 1995-09-06 |
ATE127338T1 (de) | 1995-09-15 |
MX9300101A (es) | 1994-01-31 |
KR940703654A (ko) | 1994-12-12 |
NZ246796A (en) | 1995-10-26 |
NO942525L (no) | 1994-07-05 |
DK0620729T3 (da) | 1995-12-04 |
DE69300451T2 (de) | 1996-05-02 |
NO942525D0 (no) | 1994-07-05 |
EP0620729A1 (en) | 1994-10-26 |
US5312390A (en) | 1994-05-17 |
FI943280A (fi) | 1994-07-08 |
FI943280A0 (fi) | 1994-07-08 |
JP3514756B2 (ja) | 2004-03-31 |
KR100246157B1 (ko) | 2000-04-01 |
AU659285B2 (en) | 1995-05-11 |
US5223265A (en) | 1993-06-29 |
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