ES2076175T3 - Procedimiento para la produccion de 1 alfa, 3 beta, 24-trihidroxi-delta 5-esteroides. - Google Patents

Procedimiento para la produccion de 1 alfa, 3 beta, 24-trihidroxi-delta 5-esteroides.

Info

Publication number
ES2076175T3
ES2076175T3 ES89111561T ES89111561T ES2076175T3 ES 2076175 T3 ES2076175 T3 ES 2076175T3 ES 89111561 T ES89111561 T ES 89111561T ES 89111561 T ES89111561 T ES 89111561T ES 2076175 T3 ES2076175 T3 ES 2076175T3
Authority
ES
Spain
Prior art keywords
alpha
delta
formula
beta
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89111561T
Other languages
English (en)
Inventor
Tatuo Yarino
Takao Fujii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of ES2076175T3 publication Critical patent/ES2076175T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

PROCESO PARA PRODUCCION DE 1(ALFA), 3(BETA), 24-TRIHIDROXY-DELTA5-ESTEROIDES REPRESENTADO POR LA FORMULA (II): EN DONDE R1 Y R2, INDEPENDIENTEMENTE, REPRESENTA UN ATOMO DE HIDROGENO, O R1 Y R2 JUNTOS FORMAN UN ENLACE SIMPLE, R3 REPRESENTA UN ALQUILO INFERIOR NO SUBSTITUIDO O SUBSTITUIDO POR HALOGENO, Y R4 REPRESENTA UN ATOMO DE HIDROGENO, HIDROXILO O UN HIDROXILO PROTEGIDO, COMPRENDIENDO REDUCIR UN 1(ALFA),2(ALFA)-EPOXI-(DELTA)4,6-3,24-DIOXOESTEROIDE REPRESENTADO POR LA FORMULA (I) EN DONDE R1,R2,R3 Y R4 TIENEN EL MISMO SIGNIFICADO DEFINIDO EN LA FORMULA (II), USANDO UN METAL ALCALINO O METAL ALCALINO TERREO Y UN DONANTE DE PROTONES EN UN DISOLVENTE CONTENIENDO AMONIO O AMINA CARACTERIZADO POR QUE EN UNA TEMPRANA ETAPA DE LA REACCION EL 1(ALFA),2(ALFA)-EPOXI-(DELTA)4,6-3,24- DIOXOESTEROIDE REACCIONA CON EL METAL ALCALINO O CON EL METAL ALCALINO TERREO EN PRESENCIA DE UN ACEPTADOR DE PROTONES, Y EN UNA ETAPA POSTERIOR DE LA REACCION, UN PRODUCTO INTERMEDIO RESULTANTE REACCIONA CON EL DONANTE DE PROTONES.
ES89111561T 1988-07-04 1989-06-24 Procedimiento para la produccion de 1 alfa, 3 beta, 24-trihidroxi-delta 5-esteroides. Expired - Lifetime ES2076175T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63165148A JPH0749435B2 (ja) 1988-07-04 1988-07-04 １α，３β，２４−トリヒドロキシ−△▲上５▼−ステロイド類の製造方法

Publications (1)

Publication Number Publication Date
ES2076175T3 true ES2076175T3 (es) 1995-11-01

Family

ID=15806795

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89111561T Expired - Lifetime ES2076175T3 (es) 1988-07-04 1989-06-24 Procedimiento para la produccion de 1 alfa, 3 beta, 24-trihidroxi-delta 5-esteroides.

Country Status (8)

Country Link
US (1) US5117015A (es)
EP (1) EP0349869B1 (es)
JP (1) JPH0749435B2 (es)
AT (1) ATE127126T1 (es)
DE (1) DE68924010T2 (es)
DK (1) DK174183B1 (es)
ES (1) ES2076175T3 (es)
PT (1) PT91011B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2275683A1 (en) 1996-12-20 1998-07-02 Frederik Christian Gronvald Meiosis regulating compounds
CN1906207A (zh) * 2004-01-15 2007-01-31 沃纳奇尔科特公司 乙炔雌二醇的二－甾族前体药物
WO2005070949A1 (en) * 2004-01-15 2005-08-04 Warner Chilcott Company, Inc. Di-steroidal prodrugs of estradiol
WO2007008474A2 (en) * 2005-07-12 2007-01-18 Warner Chilcott Company, Inc. 3 -ester prodrugs of estradiol
ES2523045T3 (es) * 2005-07-12 2014-11-20 Warner Chilcott Company, Llc Derivado éster de etinil estradiol

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1081424A (fr) * 1953-05-26 1954-12-20 Ile De Rech S Tech Soc Civ Procédé de préparation de dérivés du cholestane et des cholestènes di-oxygénés en position 3 et 24
US3901928A (en) * 1973-01-10 1975-08-26 Robert Henry Hesse 1' ,3' -dihydroxy steroid-5-enes method of preparing same and their use for preparing 1' -hydroxy-25-hydrogen vitamin d compounds
US4670190A (en) * 1973-01-10 1987-06-02 Hesse Robert H 1-α-hydroxy vitamin D compounds and process for preparing same
DE2400189A1 (de) * 1974-01-03 1975-07-17 Basf Ag Verfahren zur herstellung von 1 alphahydroxy-cholesterinen
US3907843A (en) * 1974-06-14 1975-09-23 Wisconsin Alumni Res Found 1{60 -Hydroxyergocalciferol and processes for preparing same
US4022891A (en) * 1974-06-18 1977-05-10 Teijin Limited Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them
IL45897A (en) * 1974-10-22 1978-12-17 Yeda Res & Dev Process for the preparation of 1 hydroxy-provitamin d3
LU80545A1 (de) * 1978-11-17 1980-06-05 Hoffmann La Roche Verfahren zur herstellung von 1a,3s-dihydroxy->5-steroiden
JPS5854160A (ja) * 1981-09-28 1983-03-31 旭化成株式会社 床下収納庫
JPH0681758B2 (ja) * 1988-04-28 1994-10-19 帝人株式会社 １α，３β−ジヒドロキシ−△▲上５▼−ステロイドの製造方法

Also Published As

Publication number Publication date
DK316689A (da) 1990-01-05
PT91011B (pt) 1995-01-31
DK316689D0 (da) 1989-06-26
EP0349869B1 (en) 1995-08-30
DE68924010D1 (de) 1995-10-05
US5117015A (en) 1992-05-26
DK174183B1 (da) 2002-08-19
EP0349869A3 (en) 1990-04-25
JPH0749435B2 (ja) 1995-05-31
EP0349869A2 (en) 1990-01-10
DE68924010T2 (de) 1996-01-25
JPH0215093A (ja) 1990-01-18
PT91011A (pt) 1990-02-08
ATE127126T1 (de) 1995-09-15

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