ES2075958T3 - Un anticuerpo monoclonal contra el precursor proteinico p55 del virus de la inmunodeficiencia humana. - Google Patents
Un anticuerpo monoclonal contra el precursor proteinico p55 del virus de la inmunodeficiencia humana.Info
- Publication number
- ES2075958T3 ES2075958T3 ES91909824T ES91909824T ES2075958T3 ES 2075958 T3 ES2075958 T3 ES 2075958T3 ES 91909824 T ES91909824 T ES 91909824T ES 91909824 T ES91909824 T ES 91909824T ES 2075958 T3 ES2075958 T3 ES 2075958T3
- Authority
- ES
- Spain
- Prior art keywords
- protein
- hiv
- cleavage site
- protease
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 239000002243 precursor Substances 0.000 title abstract 2
- 206010061598 Immunodeficiency Diseases 0.000 title 1
- 208000029462 Immunodeficiency disease Diseases 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 230000007813 immunodeficiency Effects 0.000 title 1
- 102100036089 Fascin Human genes 0.000 abstract 4
- 108010016183 Human immunodeficiency virus 1 p16 protease Proteins 0.000 abstract 3
- 238000003776 cleavage reaction Methods 0.000 abstract 3
- 230000007017 scission Effects 0.000 abstract 3
- 101710172711 Structural protein Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 230000009257 reactivity Effects 0.000 abstract 2
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010035226 Plasma cell myeloma Diseases 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004927 fusion Effects 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000012544 monitoring process Methods 0.000 abstract 1
- 201000000050 myeloid neoplasm Diseases 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 210000004989 spleen cell Anatomy 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1054—Lentiviridae, e.g. HIV, FIV, SIV gag-pol, e.g. p17, p24
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
SE PRESENTA UN ANTICUERPO MONOCLONAL QUE PRESENTA REACTIVIDAD ESPECIFICA EN CONTRA DE LA PROTEINA PRECURSORA NOMBRADA P55 QUE ES DIVIDIDA POR LA PROTEASA DEL HIV-1 EN UNA PROTEINA ESTRUCTURAL MENOR. EL ANTICUERPO DE LA INVENCION PRESENTA ACTIVIDAD ESPECIFICA CONTRA UN EPITOPO DE LA PROTEINA P55 QUE SE CORRESPONDE CON EL LUGAR DE DIVISION POR LA PROTEASA HIV-1 QUE GENERA LAS PROTEINAS ESTRUCTURALES P24 Y P17. EL ANTICUERPO ESPECIFICO ES UNA PROTEINA IGG1 CON UN PESO MOLECULAR EN EL ORDEN DE 150.000 DALTONS PRODUCIDA MEDIANTE UN HIBRIDOMA QUE SE DERIVA DE LA FUSION DE CELULAS DEL BRAZO DE UN ANIMAL INMUNIZADO CON UNA PROTEINA FUNDIDA CLONADA QUE CONTENGA UN FRAGMENTO P55 QUE INCLUYA EL LUGAR DE DIVISION P24/P17 Y UNA LINEA CELULAR DE MIELOMA. EL ANTICUERPO ESPECIFICO ES UTIL PARA MONITORIZAR LA EXPOSICION AL HIV-1, PARA EL AISLAMIENTO Y PURIFICACION DE PEPTIDOS NATURALES O SINTETICOS QUE CONTENGAN LA SECUENCIA P55 O UN FRAGMENTO DE LA MISMA QUE INCLUYA EL LUGAR DE DIVISION P24/P17 Y PARA LA SELECCION DE SUBSTANCIAS PARA LA ACTIVIDAD INHIBIDORA DE LA PROTEASA DEL HIV-1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90110461 | 1990-06-01 | ||
| EP90113658 | 1990-07-17 | ||
| EP90122813 | 1990-11-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2075958T3 true ES2075958T3 (es) | 1995-10-16 |
Family
ID=27233285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91909824T Expired - Lifetime ES2075958T3 (es) | 1990-06-01 | 1991-05-21 | Un anticuerpo monoclonal contra el precursor proteinico p55 del virus de la inmunodeficiencia humana. |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0535007B1 (es) |
| JP (1) | JPH05507409A (es) |
| KR (1) | KR930701619A (es) |
| AT (1) | ATE126238T1 (es) |
| CA (1) | CA2083399A1 (es) |
| DE (1) | DE69112059T2 (es) |
| DK (1) | DK0535007T3 (es) |
| ES (1) | ES2075958T3 (es) |
| GR (1) | GR3017444T3 (es) |
| IE (1) | IE68597B1 (es) |
| WO (1) | WO1991019000A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9929674D0 (en) * | 1999-12-15 | 2000-02-09 | Novartis Res Found | Protease-activated receptor (PAR) modulator assays |
| US6821744B2 (en) | 2002-10-29 | 2004-11-23 | Roche Diagnostics Operations, Inc. | Method, assay, and kit for quantifying HIV protease inhibitors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4886742A (en) * | 1987-06-15 | 1989-12-12 | Coulter Corporation | Enzyme immunoassay for detecting HIV antigens in human sera |
| US4888290A (en) * | 1987-11-06 | 1989-12-19 | Coulter Corporation | Monoclonal antibody specific to HIV antigens |
-
1991
- 1991-05-21 ES ES91909824T patent/ES2075958T3/es not_active Expired - Lifetime
- 1991-05-21 JP JP91509722A patent/JPH05507409A/ja active Pending
- 1991-05-21 AT AT91909824T patent/ATE126238T1/de not_active IP Right Cessation
- 1991-05-21 KR KR1019920703048A patent/KR930701619A/ko not_active Application Discontinuation
- 1991-05-21 DK DK91909824.4T patent/DK0535007T3/da active
- 1991-05-21 CA CA002083399A patent/CA2083399A1/en not_active Abandoned
- 1991-05-21 WO PCT/EP1991/000947 patent/WO1991019000A1/en active IP Right Grant
- 1991-05-21 DE DE69112059T patent/DE69112059T2/de not_active Expired - Fee Related
- 1991-05-21 EP EP91909824A patent/EP0535007B1/en not_active Expired - Lifetime
- 1991-05-31 IE IE186691A patent/IE68597B1/en not_active IP Right Cessation
-
1995
- 1995-09-20 GR GR950402570T patent/GR3017444T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0535007T3 (da) | 1995-09-25 |
| EP0535007A1 (en) | 1993-04-07 |
| IE68597B1 (en) | 1996-06-26 |
| JPH05507409A (ja) | 1993-10-28 |
| GR3017444T3 (en) | 1995-12-31 |
| CA2083399A1 (en) | 1991-12-02 |
| ATE126238T1 (de) | 1995-08-15 |
| WO1991019000A1 (en) | 1991-12-12 |
| EP0535007B1 (en) | 1995-08-09 |
| DE69112059D1 (de) | 1995-09-14 |
| KR930701619A (ko) | 1993-06-12 |
| DE69112059T2 (de) | 1996-02-29 |
| IE911866A1 (en) | 1991-12-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Danto et al. | Immunocytochemical analysis of intermediate filaments in embryonic heart cells with monoclonal antibodies to desmin. | |
| Holmdahl et al. | A rapid and efficient immunization protocol for production of monoclonal antibodies reactive with autoantigens | |
| US9902765B2 (en) | Antibodies against chikungunya virus and uses thereof | |
| US20200262915A1 (en) | Claudin 6 antibodies and uses thereof | |
| US5631349A (en) | Chimeric monoclonal antibodies recognizing human interleukin-2-receptor | |
| US5777074A (en) | Human monoclonal antibodies directed against the transmembrane glycoprotein (GP41) of human immunodeficiency virus-1 (HIV-1) | |
| ES2270461T3 (es) | Anticuerpos contra un complejo de cd4 y un dominio receptor de quemoquina, y sus usos contra las infecciones de vih. | |
| JPH02268696A (ja) | 抗ＨＩＶ―２モノクローナル抗体およびそれを用いた抗ＨＩＶ―２ｇｐ４１抗体の検出方法 | |
| Werkmeister et al. | Multiple antigenic determinants on type III collagen | |
| Gay et al. | Characterization and isolation of poly-and monoclonal antibodies against collagen for use in immunohistochemistry | |
| KR910002690B1 (ko) | Htlv-ⅲ 바이러스 관련 펩티드, 이에 대한 항체, 백신, aids바이러스에 대한 수동 및 자동 면역 및 aids바이러스의 혈청학적 진단을 위한 진단 시험 | |
| PT90582A (pt) | Anti-idiotype antibodies to anti-human high molecular weight-melanoma associated antigen | |
| DK0493446T3 (da) | Behandling af autoimmunsygdom. | |
| ES2075958T3 (es) | Un anticuerpo monoclonal contra el precursor proteinico p55 del virus de la inmunodeficiencia humana. | |
| Rathjen et al. | Identification of antigenic determinants on insulin recognized by monoclonal antibodies | |
| Jaber et al. | Characterization of murine monoclonal antibodies directed against the Kell blood group glycoprotein | |
| Gearing et al. | Use of ‘single shot’intrasplenic immunization for production of monoclonal antibodies specific for human IgM | |
| LAMAN et al. | A hidden region in the third variable domain of HIV-1 IIIB gp120 identified by a monoclonal antibody | |
| US20160347841A1 (en) | New monoclonal antibodies against the receptor dec-205 of chicken dentritic cells | |
| US5338829A (en) | Peptides derived from human immunodeficiency virus-1 GP160 | |
| KR890016165A (ko) | 수도모나스 아에루기노사(Pseudomonas aeruginosa)에 대한 모노클로날 항체, 이의 제조방법 및 용도 | |
| EP1167387A1 (en) | Antibodies against SEMP1, methods for their production and uses thereof | |
| WO1993004693A1 (en) | Synergistic inhibition of hiv-1 | |
| Ratcliffe et al. | Production and characterisation of monoclonal antibodies to parathyroid hormone-related protein | |
| Boudet et al. | Anti-idiotypic antibodies to the third variable domain of gp120 induce an anti-HIV-1 antibody response in mice |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 535007 Country of ref document: ES |