ES2074577T3 - Procedimiento para preparar 2,5-diamino-4,6-dicloropirimidina. - Google Patents

Procedimiento para preparar 2,5-diamino-4,6-dicloropirimidina.

Info

Publication number
ES2074577T3
ES2074577T3 ES90910799T ES90910799T ES2074577T3 ES 2074577 T3 ES2074577 T3 ES 2074577T3 ES 90910799 T ES90910799 T ES 90910799T ES 90910799 T ES90910799 T ES 90910799T ES 2074577 T3 ES2074577 T3 ES 2074577T3
Authority
ES
Spain
Prior art keywords
pct
diamino
dicloropirimidina
prepare
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90910799T
Other languages
English (en)
Inventor
John Hanson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of ES2074577T3 publication Critical patent/ES2074577T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

UN PROCESO PARA LA PREPARACION DE 2,5-DIAMINO-4,6-DICLOROPIRIMIDINA QUE CONSISTE EN LA CLORINACION DE 2,5-DIAMINO-4,6-DIHIDROXIPIRIMIDINA CON OXICLORURO DE FOSFORO Y UN CLORURO DE AMONIO CUATERNARIO O UN HIDROCLORURO BASICO DE AMINA TERCIARIA DEBIL.
ES90910799T 1989-07-21 1990-07-19 Procedimiento para preparar 2,5-diamino-4,6-dicloropirimidina. Expired - Lifetime ES2074577T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898916698A GB8916698D0 (en) 1989-07-21 1989-07-21 Novel process

Publications (1)

Publication Number Publication Date
ES2074577T3 true ES2074577T3 (es) 1995-09-16

Family

ID=10660401

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90910799T Expired - Lifetime ES2074577T3 (es) 1989-07-21 1990-07-19 Procedimiento para preparar 2,5-diamino-4,6-dicloropirimidina.

Country Status (12)

Country Link
US (1) US5216161A (es)
EP (1) EP0483204B1 (es)
JP (1) JPH04506802A (es)
KR (1) KR927003544A (es)
AT (1) ATE123026T1 (es)
AU (1) AU634564B2 (es)
CA (1) CA2063827A1 (es)
DE (1) DE69019749T2 (es)
DK (1) DK0483204T3 (es)
ES (1) ES2074577T3 (es)
GB (1) GB8916698D0 (es)
WO (1) WO1991001310A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9102127D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Plc Pharmaceuticals
SK279618B6 (sk) * 1992-01-22 1999-01-11 Lonza A.G. (Dir.:Basel) N-5-chránené 2,5-diamino-4,6-dichlórpyrimidíny a s
JP3305357B2 (ja) * 1992-05-21 2002-07-22 東芝機械株式会社 耐食・耐摩耗性に優れた合金およびその製造方法ならびにその合金製造用材料
GB9402161D0 (en) * 1994-02-04 1994-03-30 Wellcome Found Chloropyrimidine intermediates
GB9408270D0 (en) * 1994-04-26 1994-06-15 Zeneca Ltd Chemical process
CA2145928C (en) * 1994-04-27 2007-10-09 Gerhard Stucky N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation
US6018045A (en) * 1995-01-30 2000-01-25 Zeneca Limited Process for preparing 4,6-dichloro-pyrimidine
AT402818B (de) * 1995-06-02 1997-09-25 Chemie Linz Gmbh Verfahren zur herstellung von reinem 4,6-dichlorpyrimidin
DE59905679D1 (de) 1998-10-30 2003-06-26 Lonza Ag Verfahren zur herstellung von 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]-cyclopent-2-enylmethanolen
DK1124805T3 (da) * 1998-10-30 2003-09-15 Lonza Ag Fremgangsmåde til fremstilling af 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]cyclopent-2-enylmethanoler
DE59907401D1 (de) * 1998-12-21 2003-11-20 Lonza Ag Verfahren zur Herstellung von 2,5-Diamino-4,6-dihalogenpyrimidinen
WO2011101861A1 (en) 2010-01-29 2011-08-25 Msn Laboratories Limited Process for preparation of dpp-iv inhibitors
DE102019007519A1 (de) 2019-10-29 2021-04-29 Gomez Cao Innovations & Inventions, S.L. Eine Flasche oder Vorform für eine Flasche und ein Verschluss für eine Flasche

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH558137A (de) * 1971-05-17 1975-01-31 Ciba Geigy Ag Mittel zur beeinflussung des pflanzenwachstums.

Also Published As

Publication number Publication date
EP0483204A1 (en) 1992-05-06
JPH04506802A (ja) 1992-11-26
DE69019749T2 (de) 1995-11-23
AU6036490A (en) 1991-02-22
GB8916698D0 (en) 1989-09-06
DK0483204T3 (da) 1995-08-14
AU634564B2 (en) 1993-02-25
US5216161A (en) 1993-06-01
DE69019749D1 (de) 1995-06-29
ATE123026T1 (de) 1995-06-15
KR927003544A (ko) 1992-12-18
EP0483204B1 (en) 1995-05-24
WO1991001310A1 (en) 1991-02-07
CA2063827A1 (en) 1991-01-22

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