ATE123026T1 - Verfahren zur herstellung von 2,5-diamino-4,6- dichlorpyrimidin. - Google Patents
Verfahren zur herstellung von 2,5-diamino-4,6- dichlorpyrimidin.Info
- Publication number
- ATE123026T1 ATE123026T1 AT90910799T AT90910799T ATE123026T1 AT E123026 T1 ATE123026 T1 AT E123026T1 AT 90910799 T AT90910799 T AT 90910799T AT 90910799 T AT90910799 T AT 90910799T AT E123026 T1 ATE123026 T1 AT E123026T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- diamino
- dichloropyrimidine
- sec
- producing
- Prior art date
Links
- ZXWGHENZKVQKPX-UHFFFAOYSA-N 4,6-dichloropyrimidine-2,5-diamine Chemical compound NC1=NC(Cl)=C(N)C(Cl)=N1 ZXWGHENZKVQKPX-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- HWSJQFCTYLBBOF-UHFFFAOYSA-N 2,5-diamino-4-hydroxy-1h-pyrimidin-6-one Chemical compound NC1=NC(O)=C(N)C(O)=N1 HWSJQFCTYLBBOF-UHFFFAOYSA-N 0.000 abstract 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 238000005660 chlorination reaction Methods 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898916698A GB8916698D0 (en) | 1989-07-21 | 1989-07-21 | Novel process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE123026T1 true ATE123026T1 (de) | 1995-06-15 |
Family
ID=10660401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90910799T ATE123026T1 (de) | 1989-07-21 | 1990-07-19 | Verfahren zur herstellung von 2,5-diamino-4,6- dichlorpyrimidin. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5216161A (de) |
| EP (1) | EP0483204B1 (de) |
| JP (1) | JPH04506802A (de) |
| KR (1) | KR927003544A (de) |
| AT (1) | ATE123026T1 (de) |
| AU (1) | AU634564B2 (de) |
| CA (1) | CA2063827A1 (de) |
| DE (1) | DE69019749T2 (de) |
| DK (1) | DK0483204T3 (de) |
| ES (1) | ES2074577T3 (de) |
| GB (1) | GB8916698D0 (de) |
| WO (1) | WO1991001310A1 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9102127D0 (en) * | 1991-01-31 | 1991-03-13 | Smithkline Beecham Plc | Pharmaceuticals |
| SK279618B6 (sk) * | 1992-01-22 | 1999-01-11 | Lonza A.G. (Dir.:Basel) | N-5-chránené 2,5-diamino-4,6-dichlórpyrimidíny a s |
| JP3305357B2 (ja) * | 1992-05-21 | 2002-07-22 | 東芝機械株式会社 | 耐食・耐摩耗性に優れた合金およびその製造方法ならびにその合金製造用材料 |
| GB9402161D0 (en) * | 1994-02-04 | 1994-03-30 | Wellcome Found | Chloropyrimidine intermediates |
| GB9408270D0 (en) * | 1994-04-26 | 1994-06-15 | Zeneca Ltd | Chemical process |
| CA2145928C (en) * | 1994-04-27 | 2007-10-09 | Gerhard Stucky | N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide, and a process for its preparation |
| KR100406481B1 (ko) * | 1995-01-30 | 2004-03-24 | 신젠타 리미티드 | 4,6-디클로로-피리미딘제조방법 |
| AT402818B (de) * | 1995-06-02 | 1997-09-25 | Chemie Linz Gmbh | Verfahren zur herstellung von reinem 4,6-dichlorpyrimidin |
| HK1042474B (zh) | 1998-10-30 | 2003-11-21 | Lonza Ag | 制备4-[(2'，5'-二胺基-6'-卤代咪啶-4'-)胺]-环戊-2-烯-甲醇的方法 |
| IL142760A (en) * | 1998-10-30 | 2005-12-18 | Lonza Ag | Method for producing 4-Ä(2',5'-diamino-6'- halopyrimidine-4' -yl) aminoÜ-cyclopent -2- enyl-methanols |
| EP1188750B1 (de) * | 1998-12-21 | 2003-10-15 | Lonza AG | Verfahren zur Herstellung von 2,5-Diamino-4,6-dihalogenpyrimidinen |
| WO2011101861A1 (en) | 2010-01-29 | 2011-08-25 | Msn Laboratories Limited | Process for preparation of dpp-iv inhibitors |
| DE102019007519A1 (de) | 2019-10-29 | 2021-04-29 | Gomez Cao Innovations & Inventions, S.L. | Eine Flasche oder Vorform für eine Flasche und ein Verschluss für eine Flasche |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH558137A (de) * | 1971-05-17 | 1975-01-31 | Ciba Geigy Ag | Mittel zur beeinflussung des pflanzenwachstums. |
-
1989
- 1989-07-21 GB GB898916698A patent/GB8916698D0/en active Pending
-
1990
- 1990-07-19 DE DE69019749T patent/DE69019749T2/de not_active Expired - Fee Related
- 1990-07-19 KR KR1019920700138A patent/KR927003544A/ko not_active Withdrawn
- 1990-07-19 DK DK90910799.7T patent/DK0483204T3/da active
- 1990-07-19 AT AT90910799T patent/ATE123026T1/de not_active IP Right Cessation
- 1990-07-19 ES ES90910799T patent/ES2074577T3/es not_active Expired - Lifetime
- 1990-07-19 JP JP2510336A patent/JPH04506802A/ja active Pending
- 1990-07-19 EP EP90910799A patent/EP0483204B1/de not_active Expired - Lifetime
- 1990-07-19 CA CA002063827A patent/CA2063827A1/en not_active Abandoned
- 1990-07-19 AU AU60364/90A patent/AU634564B2/en not_active Ceased
- 1990-07-19 WO PCT/GB1990/001109 patent/WO1991001310A1/en not_active Ceased
- 1990-07-19 US US07/820,890 patent/US5216161A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0483204T3 (da) | 1995-08-14 |
| KR927003544A (ko) | 1992-12-18 |
| GB8916698D0 (en) | 1989-09-06 |
| US5216161A (en) | 1993-06-01 |
| WO1991001310A1 (en) | 1991-02-07 |
| DE69019749T2 (de) | 1995-11-23 |
| AU6036490A (en) | 1991-02-22 |
| CA2063827A1 (en) | 1991-01-22 |
| JPH04506802A (ja) | 1992-11-26 |
| ES2074577T3 (es) | 1995-09-16 |
| EP0483204B1 (de) | 1995-05-24 |
| EP0483204A1 (de) | 1992-05-06 |
| DE69019749D1 (de) | 1995-06-29 |
| AU634564B2 (en) | 1993-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |