ES2074490T3 - Procedimiento para la elaboracion de un preparado de inmunoglobulina g tolerable por via intravenosa. - Google Patents
Procedimiento para la elaboracion de un preparado de inmunoglobulina g tolerable por via intravenosa.Info
- Publication number
- ES2074490T3 ES2074490T3 ES90105405T ES90105405T ES2074490T3 ES 2074490 T3 ES2074490 T3 ES 2074490T3 ES 90105405 T ES90105405 T ES 90105405T ES 90105405 T ES90105405 T ES 90105405T ES 2074490 T3 ES2074490 T3 ES 2074490T3
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- procedure
- via intravenous
- immunoglobin
- patients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 2
- 229940027941 immunoglobulin g Drugs 0.000 title 1
- 238000001990 intravenous administration Methods 0.000 title 1
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- 102000015081 Blood Coagulation Factors Human genes 0.000 abstract 1
- 108010039209 Blood Coagulation Factors Proteins 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 239000003114 blood coagulation factor Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical class CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000002227 vasoactive effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
METODO Y ELABORACION DE UN PREPARADO G, QUE SOPORTA LA INMUNOGLOBINA INTRAVENENOSA, EL CUAL ESTA LIBRE DE GRUPOS, SUSTANCIAS VASOACTIVAS Y ENCIMAS PROTEOLITICAS Y ES APROPIADO PARA UN COLECTIVO DE PACIENTES, CONCRETAMENTE PARA LOS PACIENTES "INMUNOSUPRIMIDOS", QUE CONSTA DE UN MATERIAL DE SALIDA CON UN CONTENIDO G DE INMUNOGLOBINA, LIBRE DE FACTORES DE COAGULACION, CON UN TRATAMIENTO DE UN % DE VOLUMEN DE 0,4 A 1,5 DE ACIDOS DE OCTANO Y/O CON UNA CROMATOGRAFIA SIGUIENTE, ESPECIALMENTE, EN EL INTERCAMBIO DE CATIONES O ANIONES O DE UNA MATRIX DE CROMATOGRAFIA DE HIDROFOBEN.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP90105405A EP0447585B2 (de) | 1990-03-22 | 1990-03-22 | Verfahren zur Herstellung eines intravenös verträglichen Immunglobulin-G-Präparates |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2074490T3 true ES2074490T3 (es) | 1995-09-16 |
ES2074490T5 ES2074490T5 (es) | 2004-02-16 |
Family
ID=8203787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90105405T Expired - Lifetime ES2074490T5 (es) | 1990-03-22 | 1990-03-22 | Procedimiento para la elaboracion de un preparado de inmunoglobulina g tolerable por via intravenosa. |
Country Status (7)
Country | Link |
---|---|
US (1) | US5164487A (es) |
EP (1) | EP0447585B2 (es) |
JP (1) | JPH06107561A (es) |
AT (1) | ATE122054T1 (es) |
DE (1) | DE59009020D1 (es) |
DK (1) | DK0447585T4 (es) |
ES (1) | ES2074490T5 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
US6955917B2 (en) * | 1997-06-20 | 2005-10-18 | Bayer Healthcare Llc | Chromatographic method for high yield purification and viral inactivation of antibodies |
ES2527915T3 (es) * | 1998-06-09 | 2015-02-02 | Csl Behring Ag | Producto de inmunoglobulina G (IgG) líquido |
DE19904407C2 (de) | 1999-02-04 | 2001-09-20 | Bayer Ag | Vorrichtung zum Wechseln einer Düsenplatte eines Prillturmes und Verfahren zum automatisierten Wechsel |
SE0001128D0 (sv) * | 2000-03-30 | 2000-03-30 | Amersham Pharm Biotech Ab | A method of producing IgG |
FR2824568B1 (fr) * | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
EP1532983A1 (en) | 2003-11-18 | 2005-05-25 | ZLB Bioplasma AG | Immunoglobulin preparations having increased stability |
EP1786827A4 (en) * | 2004-05-14 | 2008-10-29 | Kirin Holdings Kk | PROCESS FOR IMMUNOGLOBULINE CLEANING |
TWI391399B (zh) | 2005-05-25 | 2013-04-01 | Hoffmann La Roche | 測定溶離多肽之鹽濃度之方法 |
FR2895263B1 (fr) | 2005-12-26 | 2008-05-30 | Lab Francais Du Fractionnement | Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives |
NZ576262A (en) * | 2006-11-01 | 2012-05-25 | Biogen Idec Inc | Method of isolating biomacromolecules using low ph and divalent cations |
EP2152745B2 (en) | 2007-06-01 | 2023-03-15 | F. Hoffmann-La Roche AG | Immunoglobulin purification |
US8772461B2 (en) | 2008-04-15 | 2014-07-08 | Grifols Therapeutics Inc. | Two-stage ultrafiltration/diafiltration |
US20090292109A1 (en) * | 2008-04-16 | 2009-11-26 | Biogen Idec Ma Inc. | Method of Isolating Biomacromolecules Using Polyalkylene Glycol and Transition Metals |
AU2011212440B2 (en) | 2010-02-04 | 2015-01-22 | Csl Behring Ag | Immunoglobulin preparation |
EP2361636A1 (en) | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
AU2010202125B1 (en) * | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
US8772462B2 (en) | 2010-05-26 | 2014-07-08 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
FR2974301B1 (fr) | 2011-04-20 | 2013-08-23 | Lab Francais Du Fractionnement | Procede de preparation d'un produit plasmatique deplete en un ou plusieurs facteurs thrombogenes |
IL212911A0 (en) * | 2011-05-16 | 2011-07-31 | Omrix Biopharmaceuticals Ltd | Immunoglobulin reduced in thrombogenic contaminants and preparation thereof |
EP2961761B1 (en) * | 2013-02-28 | 2018-09-12 | Agency For Science, Technology And Research | Protein purification in the presence of nonionic organic polymers at elevated conductivity |
KR20150123796A (ko) | 2013-02-28 | 2015-11-04 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 크로마틴 결핍 세포 배양 수확물로부터의 항체들의 크로마토그래프 정제 |
DK3016976T3 (da) | 2013-07-01 | 2020-12-07 | Csl Behring Ag | Proces |
SG11201603028SA (en) | 2013-10-18 | 2016-05-30 | Universität Für Bodenkultur Wien | Purification of proteins |
JP6700197B2 (ja) | 2014-04-30 | 2020-05-27 | ノヴォ ノルディスク アー/エス | カプリル酸を用いてタンパク質を精製する方法 |
KR101657690B1 (ko) * | 2015-06-05 | 2016-09-19 | 주식회사 녹십자홀딩스 | 혈장 유래 b형 간염 사람 면역글로불린 제제의 제조방법 |
EP3275897A1 (en) | 2016-07-27 | 2018-01-31 | Biotest AG | Process for preparing immunoglobulin compositions |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3916026A (en) * | 1968-09-19 | 1975-10-28 | Biotest Serum Institut Gmbh | Method for the preparation of gamma-globulin suitable for intravenous use |
DE3640513A1 (de) * | 1986-11-27 | 1988-06-09 | Biotest Pharma Gmbh | Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates |
EP0338229B1 (de) * | 1988-04-19 | 1993-06-16 | Biotest Pharma Gmbh | Präparat mit Antikörperaktivität und breitem Wirkungsspektrum, daraus bestehende oder diese enthaltende Mittel und deren Verwendung zur Behandlung von bakteriell oder toxin-bedingten Erkrankungen und zur Bekämpfung von Protozoen |
FR2632308B1 (fr) * | 1988-06-07 | 1991-08-16 | Fondation Nale Transfusion San | Procede et installation de fractionnement en continu de proteines vegetales animales ou humaines |
US4939176A (en) * | 1988-12-20 | 1990-07-03 | Miles Inc. | Viral inactivation process |
-
1990
- 1990-03-22 ES ES90105405T patent/ES2074490T5/es not_active Expired - Lifetime
- 1990-03-22 AT AT90105405T patent/ATE122054T1/de not_active IP Right Cessation
- 1990-03-22 DE DE59009020T patent/DE59009020D1/de not_active Expired - Lifetime
- 1990-03-22 DK DK90105405T patent/DK0447585T4/da active
- 1990-03-22 EP EP90105405A patent/EP0447585B2/de not_active Expired - Lifetime
-
1991
- 1991-03-15 US US07/669,782 patent/US5164487A/en not_active Expired - Lifetime
- 1991-03-22 JP JP3058983A patent/JPH06107561A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JPH06107561A (ja) | 1994-04-19 |
EP0447585B1 (de) | 1995-05-03 |
US5164487A (en) | 1992-11-17 |
ES2074490T5 (es) | 2004-02-16 |
ATE122054T1 (de) | 1995-05-15 |
EP0447585A1 (de) | 1991-09-25 |
DK0447585T3 (da) | 1995-05-29 |
EP0447585B2 (de) | 2003-05-07 |
DE59009020D1 (de) | 1995-06-08 |
DK0447585T4 (da) | 2003-09-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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