ES2072983T3 - Metodo para evaluar la sensibilidad de vih-1 a la zidovudina y oligonucleotidos para el mismo. - Google Patents
Metodo para evaluar la sensibilidad de vih-1 a la zidovudina y oligonucleotidos para el mismo.Info
- Publication number
- ES2072983T3 ES2072983T3 ES90308721T ES90308721T ES2072983T3 ES 2072983 T3 ES2072983 T3 ES 2072983T3 ES 90308721 T ES90308721 T ES 90308721T ES 90308721 T ES90308721 T ES 90308721T ES 2072983 T3 ES2072983 T3 ES 2072983T3
- Authority
- ES
- Spain
- Prior art keywords
- zidovudine
- hiv
- assess
- sensitivity
- oligonucleotides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000713772 Human immunodeficiency virus 1 Species 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000035945 sensitivity Effects 0.000 title abstract 2
- HBOMLICNUCNMMY-XLPZGREQSA-N zidovudine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-XLPZGREQSA-N 0.000 title abstract 2
- 229960002555 zidovudine Drugs 0.000 title abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/702—Specific hybridization probes for retroviruses
- C12Q1/703—Viruses associated with AIDS
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/974—Aids related test
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
ESTE INVENTO RELATA UNA METODOLOGIA PARA VALORAR LA SENSIBILIDAD DE UNA MUESTRA HIV-1 AL ZIDOVUDINE Y PARA DIAGNOSTICAR ENSAYOS PARA USO EN TALES VALORACIONES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB898918226A GB8918226D0 (en) | 1989-08-09 | 1989-08-09 | Dna assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2072983T3 true ES2072983T3 (es) | 1995-08-01 |
Family
ID=10661415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90308721T Expired - Lifetime ES2072983T3 (es) | 1989-08-09 | 1990-08-08 | Metodo para evaluar la sensibilidad de vih-1 a la zidovudina y oligonucleotidos para el mismo. |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US5409810A (es) |
| EP (1) | EP0422762B1 (es) |
| JP (1) | JP3105907B2 (es) |
| AU (1) | AU638475B2 (es) |
| CA (1) | CA2022942C (es) |
| DE (1) | DE69019795T2 (es) |
| DK (1) | DK0422762T3 (es) |
| ES (1) | ES2072983T3 (es) |
| GB (1) | GB8918226D0 (es) |
| IE (1) | IE69846B1 (es) |
| NZ (1) | NZ234812A (es) |
| ZA (1) | ZA906263B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE39282E1 (en) * | 1989-08-09 | 2006-09-12 | Smithkline Beecham Corporation | Nucleic acid derivatives |
| CA2042093C (en) * | 1990-05-09 | 2002-12-24 | Gyula Hadlaczky | Cell line carrying an excess of mammalian centromeres |
| AU1741692A (en) * | 1991-03-13 | 1992-10-21 | Regents Of The University Of California, The | Detection of 3'-azido-3'-deoxythymidine resistance |
| DE4129653A1 (de) * | 1991-09-06 | 1993-03-11 | Boehringer Mannheim Gmbh | Verfahren zum nachweis aehnlicher nukleinsaeuren |
| AU4248593A (en) | 1992-05-14 | 1993-12-13 | Mark Holodniy | Polymerase chain reaction assays for monitoring antiviral therapy |
| US5827648A (en) * | 1995-12-13 | 1998-10-27 | Chiron Corporation | Differential hybridization for relative quantification of variant populations |
| AU694205B2 (en) * | 1994-04-19 | 1998-07-16 | Stichting Centraal Laboratorium Van De Bloedtransfusiedienst Van Het Nederlandse Rode Kruis | Nucleic acids and methods for the discrimination between syncytium inducing and non syncytium inducing variants of the human immunodeficiency virus |
| US6265152B1 (en) | 1995-12-22 | 2001-07-24 | Visible Genetics Inc. | Method and kit for evaluation of HIV mutations |
| US6007983A (en) * | 1995-12-22 | 1999-12-28 | Visible Genetics Inc. | Method and kit for evaluation of HIV mutations |
| AU719691B2 (en) | 1996-01-26 | 2000-05-18 | Innogenetics N.V. | Method for detection of drug-induced mutations in the reverse transcriptase gene |
| US20030033617A1 (en) * | 1996-04-10 | 2003-02-13 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US20020160970A1 (en) * | 1996-04-10 | 2002-10-31 | Gyula Hadlaczky | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6077697A (en) | 1996-04-10 | 2000-06-20 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
| US6830887B2 (en) | 1997-03-18 | 2004-12-14 | Bayer Healthcare Llc | Method and kit for quantitation and nucleic acid sequencing of nucleic acid analytes in a sample |
| BR9911457A (pt) | 1998-06-24 | 2001-12-11 | Univ Emory | Uso de 3'-azida-2', 3'-dideoxiuridina em combinaçãocom drogas anti-hiv adicionais para a manufaturade um medicamento para o tratamento de hiv |
| US7115584B2 (en) * | 1999-01-22 | 2006-10-03 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| US7635690B2 (en) | 1999-01-22 | 2009-12-22 | Emory University | HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine |
| US6300075B1 (en) * | 1999-02-03 | 2001-10-09 | Ortho-Clinical Diagnostics, Inc | Enhancement of the specificity of nucleic acid amplification by carrier nucleic acid |
| US7074556B2 (en) * | 1999-03-02 | 2006-07-11 | Invitrogen Corporation | cDNA synthesis improvements |
| EP1185712B8 (en) | 1999-05-28 | 2005-10-19 | Virco Bvba | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
| EP2020450B9 (en) * | 2000-09-01 | 2011-09-14 | Gen-Probe Incorporated | Amplification of HIV-1 sequences for detection of sequences associated with drug-resistance mutations |
| ES2399806T3 (es) * | 2000-09-28 | 2013-04-03 | Bioriginal Food & Science Corp. | Miembro de la familia de desaturasa de ácido graso fad6 y usos del mismo |
| AU2631602A (en) | 2000-10-20 | 2002-04-29 | Virco Nv | New mutational profiles in hiv-1 reverse transcriptase correlated with phenotypic drug resistance |
| WO2004003817A1 (en) | 2002-07-01 | 2004-01-08 | Tibotec Pharmaceuticals Ltd. | Mutational profiles in hiv-1 protease correlated with phenotypic drug resistance |
| ATE397669T1 (de) | 2002-07-01 | 2008-06-15 | Tibotec Pharm Ltd | Mit phänotypischer medikamentenresistenz korrelierte mutationsprofile in hiv-1-reverse- transkriptase |
| US6834479B2 (en) * | 2002-10-03 | 2004-12-28 | Src Innovations, Llc | Bagging machine having a collapsible tunnel |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU606043B2 (en) * | 1985-03-28 | 1991-01-31 | F. Hoffmann-La Roche Ag | Detection of viruses by amplification and hybridization |
-
1989
- 1989-08-09 GB GB898918226A patent/GB8918226D0/en active Pending
-
1990
- 1990-08-08 IE IE286090A patent/IE69846B1/en not_active IP Right Cessation
- 1990-08-08 CA CA002022942A patent/CA2022942C/en not_active Expired - Lifetime
- 1990-08-08 ZA ZA906263A patent/ZA906263B/xx unknown
- 1990-08-08 AU AU60828/90A patent/AU638475B2/en not_active Expired
- 1990-08-08 ES ES90308721T patent/ES2072983T3/es not_active Expired - Lifetime
- 1990-08-08 DE DE69019795T patent/DE69019795T2/de not_active Expired - Lifetime
- 1990-08-08 EP EP90308721A patent/EP0422762B1/en not_active Expired - Lifetime
- 1990-08-08 NZ NZ234812A patent/NZ234812A/xx unknown
- 1990-08-08 DK DK90308721.1T patent/DK0422762T3/da active
- 1990-08-09 JP JP02211465A patent/JP3105907B2/ja not_active Expired - Lifetime
-
1992
- 1992-12-01 US US07/984,255 patent/US5409810A/en not_active Ceased
-
1997
- 1997-04-23 US US08/839,010 patent/USRE37918E1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2022942C (en) | 1999-12-21 |
| GB8918226D0 (en) | 1989-09-20 |
| EP0422762A3 (en) | 1992-08-05 |
| EP0422762B1 (en) | 1995-05-31 |
| IE902860A1 (en) | 1991-02-27 |
| DE69019795T2 (de) | 1995-11-02 |
| JP3105907B2 (ja) | 2000-11-06 |
| USRE37918E1 (en) | 2002-12-03 |
| AU638475B2 (en) | 1993-07-01 |
| EP0422762A2 (en) | 1991-04-17 |
| CA2022942A1 (en) | 1991-02-10 |
| NZ234812A (en) | 1991-09-25 |
| ZA906263B (en) | 1992-04-29 |
| US5409810A (en) | 1995-04-25 |
| JPH03133400A (ja) | 1991-06-06 |
| IE69846B1 (en) | 1996-10-02 |
| AU6082890A (en) | 1991-02-14 |
| DK0422762T3 (da) | 1995-07-24 |
| DE69019795D1 (de) | 1995-07-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2072983T3 (es) | Metodo para evaluar la sensibilidad de vih-1 a la zidovudina y oligonucleotidos para el mismo. | |
| BR8302286A (pt) | Aperfeicoamento em processo para determinacao da presenca de um analisador em uma amostra, aparelho de diagnostico inteiramente calibrado e kit para uso em um ensaio diagnostico | |
| ES2160714T3 (es) | Analisis y dispositivos para la deteccion de atresia biliar extrahepatica. | |
| ES2116578T3 (es) | Procedimiento y dispositivo para evaluar la aptitud de biopolimeros. | |
| DE69429481D1 (de) | Anzeigevorrichtung für die Ergebnisse von klinischen Tests | |
| BR7503071A (pt) | Cartao de teste de diagnostico e processo para determinacao de funcao ou estado de um orgao pelo emprego do dito cartao de teste | |
| DE69010785D1 (de) | System zum Messen von durch ein Endoskop beobachteten Gegenständen. | |
| DE3689490D1 (de) | Elektronenstrahlprüfsonde zur Untersuchung integrierter Schaltungen. | |
| BR9708421A (pt) | Processo para a deteccão de doenca provocada por prions teste diagnostico ou kit de teste e uso do processo | |
| IT8521902A0 (it) | Procedimento e dispositivo per la misurazione degli spessori sui pezzi in prova mediante ultrasuoni. | |
| DK0782706T3 (da) | Testmetode | |
| MX9706437A (es) | Proceso y compuestos para la deteccion de analitos usando medicion de remanencia y el uso de los mismos. | |
| DE59006427D1 (de) | Mehrkomponenten-Kraftmessanordnung ohne Messplatte. | |
| IT1100970B (it) | Apaprecchiatura di prova o collaudo ultrasonico | |
| DE58909813D1 (de) | Vorrichtung für die zerstörungsfreie Werkstoffprüfung | |
| BR9407504A (pt) | Dispositivo de teste para ensaio kit para realizar um ensaio e processo para determinar a presença de um anólito em um individuo em teste | |
| ES2187674T3 (es) | Procedimiento de deteccion del cancer. | |
| ES2149505T3 (es) | Mejoras en o relacionadas con un aparato de ensayo de construcciones. | |
| BR7406779D0 (pt) | Preparacao antigena processo e cartao de teste para realizacao de um teste de aglutinacao para sifilis e outras doencas causadas por treponema | |
| Jones et al. | Comparison of R-resistance curves(fracture strength) | |
| Brinson et al. | Test specimen geometries for evaluating adhesive durability | |
| IT7868394A0 (it) | Apparecchio per la valutazione qualitativa di prove di stampa e simili | |
| KR970046795U (ko) | 웨이퍼 테스트용 양면 프로브카드 | |
| UA9571A (uk) | Спосіб електропунктурної діагностики "дін" та пристрій для його здійснення | |
| DE59401353D1 (de) | Prüfeinrichtung zur zerstörungsfreien werkstoffprüfung |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 422762 Country of ref document: ES |