ES2070960T3 - Procedimiento para la fabricacion de un medicamento conteniendo igg, iga e igm, de administracion intravenosa. - Google Patents

Procedimiento para la fabricacion de un medicamento conteniendo igg, iga e igm, de administracion intravenosa.

Info

Publication number
ES2070960T3
ES2070960T3 ES90114575T ES90114575T ES2070960T3 ES 2070960 T3 ES2070960 T3 ES 2070960T3 ES 90114575 T ES90114575 T ES 90114575T ES 90114575 T ES90114575 T ES 90114575T ES 2070960 T3 ES2070960 T3 ES 2070960T3
Authority
ES
Spain
Prior art keywords
igm
procedure
iga
manufacture
intravenous administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90114575T
Other languages
English (en)
Inventor
Ronald Dipl-Chem Dr Kotitschke
Wolfgang Dipl-Chem Dr Stephan
Wolfgang Dipl-Chem Dr Moller
Detlef Dipl-Chem Dr Piechaczek
Dieter Dipl-Chem Dr Rudnick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotest Pharma GmbH
Original Assignee
Biotest Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotest Pharma GmbH filed Critical Biotest Pharma GmbH
Application granted granted Critical
Publication of ES2070960T3 publication Critical patent/ES2070960T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

EL INVENTO SE REFIERE A UN PROCEDIMIENTO, QUE SE UTILIZA PARA PRODUCIR UNA SOLUCION DE INMUNOGLOBINA QUE SE APLICA POR VIA INTRAVENOSA, Y QUE PROCEDE DE UNA FRACCION DE PROTEINA QUE PERTENECE A LA SANGRE HUMANA Y CONTIENE EN FORMA NO CONCENTRADA, INMUNOGLOBINA IGG, IGA, IGM Y CONSISTE EN, ADICIONAR LA FRACCION DE PROTEINA CON UN TAMPON DE ACETATO; FILTRAR EL COMPONENTE NO SOLUBLE DE LA REACCION; TREATAR EL PRECOPITADO CON FOSFATO CALCICO Y ACIDO OCTANICO; CENTRIFUGAR LA MEZCLA PRODUCIDA; SEPARAR EL EXCESO DEL CENTRIFUGADO; TRATAR EL EXCFESO DE CENTRIOFUGADO CON UN MEDIO DE ABSORCION; SEPARAR EL MEDIO DE ABSORCION Y FILTRAR EL RESIDUO Y ESTERIZARLO.
ES90114575T 1989-08-17 1990-07-30 Procedimiento para la fabricacion de un medicamento conteniendo igg, iga e igm, de administracion intravenosa. Expired - Lifetime ES2070960T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3927112A DE3927112C1 (es) 1989-08-17 1989-08-17

Publications (1)

Publication Number Publication Date
ES2070960T3 true ES2070960T3 (es) 1995-06-16

Family

ID=6387264

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90114575T Expired - Lifetime ES2070960T3 (es) 1989-08-17 1990-07-30 Procedimiento para la fabricacion de un medicamento conteniendo igg, iga e igm, de administracion intravenosa.

Country Status (6)

Country Link
US (1) US5075425A (es)
EP (1) EP0413187B1 (es)
JP (1) JPH0768144B2 (es)
AT (1) ATE120963T1 (es)
DE (2) DE3927112C1 (es)
ES (1) ES2070960T3 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0835880A1 (de) * 1996-10-14 1998-04-15 Rotkreuzstiftung Zentrallaboratorium Blutspendedienst Srk Verfahren zur Herstellung eines IgM Präparates für die intravenöse Applikation
US6955917B2 (en) * 1997-06-20 2005-10-18 Bayer Healthcare Llc Chromatographic method for high yield purification and viral inactivation of antibodies
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
US20030072812A1 (en) * 2001-05-10 2003-04-17 Sirbasku David A Breast cancer eradication program
US8119138B2 (en) * 2000-05-10 2012-02-21 Signe Biopharma Inc. Anti-estrogen and immune modulator combinations for treating breast cancer
AU2001269690A1 (en) 2000-05-10 2001-11-20 David A. Sirbasku Compositions and methods for demonstrating secretory immune system regulation of steroid hormone responsive cancer cell growth
US7863011B2 (en) * 2000-05-10 2011-01-04 Signe Biopharma, Inc. Screening method for predicting susceptibility to breast cancer
FR2824568B1 (fr) * 2001-05-11 2004-04-09 Lab Francais Du Fractionnement Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique
BRPI0507298A (pt) * 2004-01-30 2007-07-03 Suomen Punainen Risti Veripalv processo para a produção de imunoglobulina segura a vìrus
JP5697847B2 (ja) * 2006-01-30 2015-04-08 グリフオルス・セラピユーテイクス・インコーポレーテツドＧｒｉｆｏｌｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ＩｇＭを使用する治療方法および予防方法
GB201006753D0 (en) 2010-04-22 2010-06-09 Biotest Ag Process for preparing an immunolobulin composition
CN101948535B (zh) * 2010-09-27 2012-11-07 浙江大学 一种从鸡血中分离免疫球蛋白IgY的方法
FR2977893B1 (fr) * 2011-07-11 2015-02-20 Lab Francais Du Fractionnement Procede de preparation d'un concentre d'immunoglobulines polyvalentes
US9096648B2 (en) * 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
CN102584934B (zh) * 2012-03-19 2013-11-06 江西博雅生物制药股份有限公司 一种静注人免疫球蛋白的制备工艺
EP3275897A1 (en) 2016-07-27 2018-01-31 Biotest AG Process for preparing immunoglobulin compositions
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3808189A (en) * 1973-03-15 1974-04-30 American Cyanamid Co Isolation of gamma globulin preparations enriched in iga and igm using polyethylene glycol
DE2901822A1 (de) * 1979-01-18 1980-07-31 Biotest Serum Institut Gmbh Verfahren zur herstellung einer fuer die intravenoese applikation geeigneten immunglobulinloesung, die igm in ankonzentrierter form enthaelt
DE3825429C2 (de) * 1988-07-27 1994-02-10 Biotest Pharma Gmbh Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt

Also Published As

Publication number Publication date
DE3927112C1 (es) 1990-10-25
JPH0768144B2 (ja) 1995-07-26
JPH0383932A (ja) 1991-04-09
ATE120963T1 (de) 1995-04-15
EP0413187A1 (de) 1991-02-20
DE59008883D1 (de) 1995-05-18
EP0413187B1 (de) 1995-04-12
US5075425A (en) 1991-12-24

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