ES2070942T3 - Metodo y dispositivo para la separacion de plasma o suero de sangre completa. - Google Patents

Metodo y dispositivo para la separacion de plasma o suero de sangre completa.

Info

Publication number
ES2070942T3
ES2070942T3 ES90106605T ES90106605T ES2070942T3 ES 2070942 T3 ES2070942 T3 ES 2070942T3 ES 90106605 T ES90106605 T ES 90106605T ES 90106605 T ES90106605 T ES 90106605T ES 2070942 T3 ES2070942 T3 ES 2070942T3
Authority
ES
Spain
Prior art keywords
matrix
plasma
serum
sintered
filter means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90106605T
Other languages
English (en)
Inventor
Diane L Aunet
Kristin D Elmore
Gradimir G Georgevich
Gary M Oosta
Neal A Siegel
Tzyy-Wen Jeng
Terry A Pry
Cathy R Silverman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/335,064 external-priority patent/US4933092A/en
Priority claimed from US07/499,864 external-priority patent/US5064541A/en
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2070942T3 publication Critical patent/ES2070942T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • B01D39/1607—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being fibrous
    • B01D39/1623—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being fibrous of synthetic origin
    • B01D39/163—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being fibrous of synthetic origin sintered or bonded
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • B01D39/1638—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being particulate
    • B01D39/1653—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being particulate of synthetic origin
    • B01D39/1661—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being particulate of synthetic origin sintered or bonded
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/16—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres
    • B01D39/18—Other self-supporting filtering material ; Other filtering material of organic material, e.g. synthetic fibres the material being cellulose or derivatives thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/20—Other self-supporting filtering material ; Other filtering material of inorganic material, e.g. asbestos paper, metallic filtering material of non-woven wires
    • B01D39/2003—Glass or glassy material
    • B01D39/2006—Glass or glassy material the material being particulate
    • B01D39/201—Glass or glassy material the material being particulate sintered or bonded by inorganic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/20—Other self-supporting filtering material ; Other filtering material of inorganic material, e.g. asbestos paper, metallic filtering material of non-woven wires
    • B01D39/2027—Metallic material
    • B01D39/2031—Metallic material the material being particulate
    • B01D39/2034—Metallic material the material being particulate sintered or bonded by inorganic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/20—Other self-supporting filtering material ; Other filtering material of inorganic material, e.g. asbestos paper, metallic filtering material of non-woven wires
    • B01D39/2068—Other inorganic materials, e.g. ceramics
    • B01D39/2072—Other inorganic materials, e.g. ceramics the material being particulate or granular
    • B01D39/2075—Other inorganic materials, e.g. ceramics the material being particulate or granular sintered or bonded by inorganic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Geology (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Clinical Laboratory Science (AREA)
  • Ceramic Engineering (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

UN DISPOSITIVO Y METODO PARA PERMITIR LA SEPARACION DE PLASMA O SUERO DE SANGRE COMPLETA. EL DISPOSITIVO CONSTA DE UNA MATRIZ DE MATERIAL POROSO SINTERIZADO HIDROFILICO AL QUE SE HA APLICADO AL MENOS UN AGENTE AGLUTINANTE DE CELULA DE SANGRE ROJA. DE ACUERDO CON UN PRIMER METODO PARA USAR EL DISPOSITIVO, SE APLICA UNA MUESTRA DE SANGRE ROJA A UN PRIMER EXTREMO DE LA MATRIZ Y LAS CELULAS DE SANGRE ROJA DENTRO DE LA MUESTRA ENTRAN EN CONTACTO CON LOS AGENTES AGLUTINANTES PRESENTES EN LA MATRIZ. LAS CELULAS DE SANGRE SE AGLUTINAN, Y SON OCLUIDAS EN LOS INTERSTICIOS DE LA MATRIZ, MIENTRAS EL SUERO O PLASMA ESENCIALMENTE LIBRES DE CELULAS DE SANGRE SE ACUMULAN CERCA DE LA SALIDA DEL DISPOSITIVO. UN SISTEMA DE FILTRO EN LIQUIDO ENTRA EN RELACION CON LAS FUNCIONES DE LA MATRIZ PARA EL ASCENSO DEL SUERO O PLASMA DESDE LA MATRIZ. DE ACUERDO CON UN ASPECTO ALTERNATIVO DEL INVENTO, UN SISTEMA DE FILTRO EN LIQUIDO ENTRA EN RELACION CON LA SALIDA DE LAS FUNCIONES DE LA MATRIZ PARA RETENER CUALQUIER CELULA DE SANGRE QUE PASE A TRAVES DE LA MATRIZ CUANDO EL SISTEMA DE FILTRO PRODUCE EL ASCENSO DEL PLASMA O DEL SUERO DESDE LA MATRIZ. SE PUEDEN INCORPORAR AGENTES AGLUTINANTES ADICIONALES DENTRO DEL SISTEMA DE FILTRO PARA FACILITAR LA RETENCION DE LAS CELULAS DE SANGRE QUE PASEN A TRAVES DE LA MATRIZ. OTRO ASPECTO DE ESTE INVENTO IMPLICA UN DISPOSITIVO PARA LA MEDIDA DE UNA MUESTRA DE SUERO O PLASMA, UTILIZANDO UNA MATRIZ DE MATERIAL POROSO SINTERIZADO, TAL COMO VIDRIO SINTERIZADO, ACERO SINTERIZADO, CERAMICA SINTERIZADA, PLASTICO SINTERIZADO, Y OTROS EQUIVALENTES. LA MATRIZ SE CARACTERIZA POR UNA CAPACIDAD DE SUBIDA DE FLUIDO REPRODUCIBLE PROPORCIONAL A LAS DIMENSIONES FIJAS DE DICHA MATRIZ, UNA REACTIVIDAD MINIMA CON COMPONENTES DE SUERO O PLASMA, Y UNA SUPERFICIE INTERNA HIDROFILICA QUE PERMITE A LA MATRIZ RECOGER Y RETENER UN VOLUMEN PREDETERMINADO DE MUESTRA PARA EL ANALISIS. OTRO ASPECTO DEL PRESENTE INVENTO PROPORCIONA UN SISTEMA DE DESARROLLO DE REACTIVO POROSO QUE CONSTA DE UNA MATRIZDE MATERIAL POROSO SINTERIZADO QUE CONTIENE AL MENOS UN REACTIVO EN UN ESTADO DE CONGELADO EN SECO, Y UN METODO PARA HACER LO MISMO. EL SISTEMA PERMITE EL DESARROLLO DE UN MOLDE UNIFICADO DE UN REACTIVO CONGELADO EN SECO QUE ES RECUPERABLE AL ENTRAR EN CONTACTO CON UN LIQUIDO.
ES90106605T 1989-04-07 1990-04-06 Metodo y dispositivo para la separacion de plasma o suero de sangre completa. Expired - Lifetime ES2070942T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/335,064 US4933092A (en) 1989-04-07 1989-04-07 Methods and devices for the separation of plasma or serum from whole blood
US49992890A 1990-03-27 1990-03-27
US07/499,864 US5064541A (en) 1989-04-07 1990-03-27 Devices and methods for the collection of a predetermined volume of plasma or serum

Publications (1)

Publication Number Publication Date
ES2070942T3 true ES2070942T3 (es) 1995-06-16

Family

ID=27407026

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90106605T Expired - Lifetime ES2070942T3 (es) 1989-04-07 1990-04-06 Metodo y dispositivo para la separacion de plasma o suero de sangre completa.

Country Status (8)

Country Link
EP (1) EP0392377B1 (es)
JP (3) JP2940990B2 (es)
KR (1) KR910016365A (es)
AT (1) ATE118615T1 (es)
AU (1) AU630942B2 (es)
CA (1) CA2014119C (es)
DE (1) DE69016813T2 (es)
ES (1) ES2070942T3 (es)

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FI940823A0 (fi) * 1994-02-22 1994-02-22 Orion Yhtymae Oy Analysatorkyvett foer turbidimetriska och nefelometriska bestaemningar av helblodsprov
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WO1998040735A1 (fr) * 1997-03-12 1998-09-17 Kyoto Daiichi Kagaku Co., Ltd. Instrument d'analyse d'echantillon liquide
US6248542B1 (en) 1997-12-09 2001-06-19 Massachusetts Institute Of Technology Optoelectronic sensor
JP2000187032A (ja) * 1998-12-21 2000-07-04 Nagase & Co Ltd 血清分離方法及び装置
US7947236B2 (en) 1999-12-03 2011-05-24 Becton, Dickinson And Company Device for separating components of a fluid sample
JP3418374B2 (ja) * 2000-11-06 2003-06-23 株式会社いかがく 乾燥型試料搬送容器
US7422860B2 (en) 2001-02-07 2008-09-09 Massachusetts Institute Of Technology Optoelectronic detection system
US8216797B2 (en) 2001-02-07 2012-07-10 Massachusetts Institute Of Technology Pathogen detection biosensor
US7214346B2 (en) 2001-02-07 2007-05-08 Massachusetts Institute Of Technology Optoelectronic detection system
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FI20040825A0 (fi) 2004-06-15 2004-06-15 Ani Biotech Oy Suodatinväline, sen käyttö, menetelmä ja kitti
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AU2006350038B2 (en) * 2005-11-30 2011-09-15 Massachusetts Institute Of Technology Pathogen detection biosensor
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CN102149473B (zh) 2008-07-21 2014-12-31 贝克顿·迪金森公司 密度相分离装置
PL3821980T3 (pl) 2009-05-15 2023-02-20 Becton, Dickinson And Company Urządzenie do rozdzielania faz gęstości
US9198609B2 (en) 2011-04-19 2015-12-01 Porex Corporation Cards for sample storage and delivery comprising sintered porous plastic
EP2721407B1 (en) * 2011-06-15 2017-09-20 Pfaff, Tim Plasma or serum separator
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WO2013147308A1 (ja) 2012-03-30 2013-10-03 積水メディカル株式会社 赤血球含有サンプル中の対象物を検出するためのイムノクロマトグラフィー用テストストリップおよびイムノクロマトグラフィーを利用した検出方法
US9885707B2 (en) 2012-03-30 2018-02-06 Sekisui Medical Co., Ltd. Immunochromatographic test strip and detection method using immunochromatography for detecting object in red blood cell-containing sample
FR3012972A1 (fr) * 2013-11-14 2015-05-15 Biomerieux Sa Nouveau milieu filtrant pour l'obtention de plasma, dispositif et procede de filtration associes
WO2015085066A1 (en) 2013-12-06 2015-06-11 BacterioScan Inc. Optical measurement cuvette having sample chambers
US9694359B2 (en) 2014-11-13 2017-07-04 Becton, Dickinson And Company Mechanical separator for a biological fluid
CN110780066A (zh) 2014-12-16 2020-02-11 积水医疗株式会社 用于检测含红细胞的样品中的对象物的免疫色谱用测试条、及使用该测试条的免疫色谱
CN108473932B (zh) 2015-09-09 2022-07-15 集联健康有限公司 用于样品收集、稳定化和保存的系统、方法和装置
CN111220431A (zh) * 2016-10-26 2020-06-02 上海万承生物科技有限公司 一种检测血浆活性成分方法及应用该方法的血浆卡
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CN110018301B (zh) * 2018-01-09 2024-06-25 上海八通生物科技股份有限公司 一种组合式免疫层析装置
CN108872220B (zh) * 2018-07-11 2020-03-24 深圳华创生物医药科技有限公司 一种无汞对羟基苯丙氨酸检测试剂及制备方法和应用
CN109529958A (zh) * 2018-12-14 2019-03-29 上海艾瑞德生物科技有限公司 全血过滤和血浆定量微流控芯片
JP7495426B2 (ja) 2019-03-14 2024-06-04 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥容器用充填治具、システム及び使用方法
CN112569686B (zh) * 2019-09-30 2022-08-09 成都易态科技有限公司 复合多孔薄膜的制备方法
WO2021171378A1 (ja) * 2020-02-25 2021-09-02 Ｂｌｕｅ Ｉｎｄｕｓｔｒｉｅｓ株式会社 分離装置、検出装置、保存装置及びセンサ
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WO2023154110A1 (en) * 2022-02-11 2023-08-17 Abbott Point Of Care Inc. Apparatus and devices for processing fluid samples

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Also Published As

Publication number Publication date
JP2000329761A (ja) 2000-11-30
AU630942B2 (en) 1992-11-12
EP0392377A2 (en) 1990-10-17
KR910016365A (ko) 1991-11-05
JPH11230963A (ja) 1999-08-27
EP0392377B1 (en) 1995-02-15
CA2014119A1 (en) 1990-10-07
DE69016813D1 (de) 1995-03-23
EP0392377A3 (en) 1990-11-22
JP2940990B2 (ja) 1999-08-25
CA2014119C (en) 2000-11-21
DE69016813T2 (de) 1995-09-07
JPH03205563A (ja) 1991-09-09
ATE118615T1 (de) 1995-03-15
AU5306290A (en) 1990-10-11

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