ES2069446T3 - Preparacion de hidrocloruro de ranitidina en forma 1. - Google Patents

Preparacion de hidrocloruro de ranitidina en forma 1.

Info

Publication number
ES2069446T3
ES2069446T3 ES93304182T ES93304182T ES2069446T3 ES 2069446 T3 ES2069446 T3 ES 2069446T3 ES 93304182 T ES93304182 T ES 93304182T ES 93304182 T ES93304182 T ES 93304182T ES 2069446 T3 ES2069446 T3 ES 2069446T3
Authority
ES
Spain
Prior art keywords
hypochloride
ranitidine
preparation
solvent
prepared
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93304182T
Other languages
English (en)
Inventor
Teng-Ko Ngooi
Casimir Antczak
Jeffrey David Mcgolrick
James Lorne Anthony Tindall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torcan Chemical Ltd
Original Assignee
Torcan Chemical Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torcan Chemical Ltd filed Critical Torcan Chemical Ltd
Application granted granted Critical
Publication of ES2069446T3 publication Critical patent/ES2069446T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE PREPARA HIPOCLORURO DE RANITIDINA DE FORMA PURA 1 POR UN PROCESO DE CRISTALIZACION DE UNA SOLUCION DE HIPOCLORURO DE RANITINA EN UN SOLVENTE MEZCLADO QUE COMPRENDE 1 PARTE POR VOLUMEN DE AL MENOS UN ALCANOL INFERIOR TAL COMO UN ETANOL Y 1 20 PARTES POR VOLUMEN DE UN HIDROCARBURO AROMATICO C6-C10 TAL COMO TOLUENO, Y EN PRESENCIA DE CRISTALES DE SEMILLAS DE HIPOCLORURO DE RANITIDINA DE FORMA PURA !. EN EL PROCESO PREFERIDO DE ACUERDO CON LA INVENCION, EL HIPOCLORURO DE RANITIDINA SE PREPARA IN SITU EN LA MEZCLA DE SOLVENTE AÑADIENDO ACIDO HIDROCLORICO A UNA SOLUCION DE LA BASE LIBRE EN LA MEZCLA DE SOLVENTE, EN PRESENCIA DE CRISTALES DE SEMILLAS.
ES93304182T 1993-04-01 1993-05-28 Preparacion de hidrocloruro de ranitidina en forma 1. Expired - Lifetime ES2069446T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US08/041,354 US5338871A (en) 1991-12-20 1993-04-01 Preparation of form 1 ranitidine hydrochloride
EP93304182A EP0626381B1 (en) 1993-04-01 1993-05-28 Preparation of form 1 ranitidine hydrochloride
CA002099530A CA2099530C (en) 1993-04-01 1993-07-02 Preparation of form 1 ranitidine hydrochloride
AU41794/93A AU674006B2 (en) 1993-04-01 1993-07-06 Preparation of form 1 ranitidine hydrochloride
HU9301980A HU214334B (hu) 1993-04-01 1993-07-08 Eljárás ranitidin-hidroklorid 1 kristályformájának előállítására
ZA934995A ZA934995B (en) 1993-04-01 1993-07-12 Preparation of form 1 ranitidine hydrochloride
NZ260551A NZ260551A (en) 1993-04-01 1994-05-18 Preparation of form 1 ranitidine hcl crystals

Publications (1)

Publication Number Publication Date
ES2069446T3 true ES2069446T3 (es) 1995-05-01

Family

ID=27560579

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93304182T Expired - Lifetime ES2069446T3 (es) 1993-04-01 1993-05-28 Preparacion de hidrocloruro de ranitidina en forma 1.

Country Status (11)

Country Link
US (1) US5338871A (es)
EP (1) EP0626381B1 (es)
AT (1) ATE119894T1 (es)
AU (1) AU674006B2 (es)
CA (1) CA2099530C (es)
DE (1) DE69300088T2 (es)
DK (1) DK0626381T3 (es)
ES (1) ES2069446T3 (es)
HU (1) HU214334B (es)
NZ (1) NZ260551A (es)
ZA (1) ZA934995B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4341310A1 (de) * 1993-12-03 1995-06-08 Hexal Pharma Gmbh Tablette oder Kapsel mit einem Gehalt an stabilem Ranitidinhydrochlorid Form 1
CA2120874E (en) * 1994-04-08 2002-01-08 Keshava Murthy Form of form 1 ranitidine
US5670671A (en) * 1994-04-08 1997-09-23 Brantford Chemicals Inc. Process for the production of an improved form of form 1 ranitidine
NZ272054A (en) * 1994-05-13 1996-05-28 Ranbaxy Lab Ltd Process for producing form 1 ranitidine hydrochloride
IN181699B (es) * 1994-05-13 1998-09-05 Ranbaxy Lab Ltd
DE69504156T2 (de) * 1994-06-24 1998-12-24 Ranbaxy Laboratories, Ltd., New Delhi Verfahren zur Herstellung von Ranitidinhydrochlorid in der Kristallform 1
WO1996019232A1 (en) * 1994-12-19 1996-06-27 Lauteral Limited Combinations of ranitidine hydrochloride-form 1 and bismuth compounds
US5663381A (en) * 1995-04-21 1997-09-02 Hexal Pharmaceuticals, Inc. Process for preparing form 1 ranitidine hydrochloride
US5686588A (en) * 1995-08-16 1997-11-11 Yoo; Seo Hong Amine acid salt compounds and process for the production thereof
DE69739561D1 (de) 1996-06-13 2009-10-15 Sumitomo Chemical Co Piperidin Derivative als Zwischenprodukte zur Herstellung von Paroxetine und Verfahren zu ihrer Herstellung
US20020151729A1 (en) * 1997-02-26 2002-10-17 Cheng Wen J. Novel process for the preparation of form 1 ranitidine hydrochloride
IE990387A1 (en) * 1998-06-17 2000-12-13 Russinsky Ltd A ranitidine base water adduct
IT1317858B1 (it) 2000-02-29 2003-07-15 Pharmexcel S R L Allomorfo del cloridrato dell'isomero z di derivato dialchilamminofurano, procedimento per la sua produzione e composizione
DE102006015960A1 (de) * 2006-04-04 2007-10-11 Qiagen Gmbh Gemisch reversibel inhibierter Enzyme
JP2013533866A (ja) * 2010-06-17 2013-08-29 ドクター レディズ ラボラトリーズ リミテッド ３−アミノピペリジンジヒドロクロリドの単一の鏡像異性体を調製するための方法
WO2015155297A1 (en) 2014-04-11 2015-10-15 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of dabigatran and h2-receptor antagonists
WO2015169957A1 (en) 2014-05-09 2015-11-12 Sanovel Ilac Sanayi Ve Ticaret A.S. Pharmaceutical combinations of rivaroxaban and h2-receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1181084A (en) * 1980-01-08 1985-01-15 Glaxo Group Limited Process for the preparation of a furan derivative
GB2084580B (en) * 1980-10-01 1984-07-04 Glaxo Group Ltd Aminoalkyl furan derivative
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
DE3211127C1 (de) * 1982-03-26 1983-08-11 Degussa Ag, 6000 Frankfurt Verfahren zur Gewinnung von S-(Carboxymethyl)-(R)-cystein und S-(Carboxymethyl)-(S)-cystein
US4613688A (en) * 1982-04-02 1986-09-23 Showa Denko Kabushiki Kaisha Optical resolution process for DL-cysteine
JPH0730064B2 (ja) * 1989-08-17 1995-04-05 協和醗酵工業株式会社 フラン誘導体

Also Published As

Publication number Publication date
AU674006B2 (en) 1996-12-05
ATE119894T1 (de) 1995-04-15
ZA934995B (en) 1994-02-11
HU9301980D0 (en) 1993-09-28
DE69300088T2 (de) 1995-08-31
HUT68736A (en) 1995-04-27
EP0626381A1 (en) 1994-11-30
CA2099530C (en) 2002-10-08
NZ260551A (en) 1995-02-24
HU214334B (hu) 1998-03-02
EP0626381B1 (en) 1995-03-15
CA2099530A1 (en) 1995-01-03
AU4179493A (en) 1995-01-27
DE69300088D1 (de) 1995-04-20
DK0626381T3 (da) 1995-10-02
US5338871A (en) 1994-08-16

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