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Publication of YU32904ApublicationCriticalpatent/YU32904A/sh
Medicines That Contain Protein Lipid Enzymes And Other Medicines
(AREA)
Abstract
Dati pronalazak se odnosi na formulacije koje sadrže analoge ciklosporina koji su strukturno slični ciklosporinu A, a naročito su izometrijske smeše analoga ciklosporina strukturno slične ciklosporinu A. Formulacije formiraju stabilne mikroemulzione prekoncentrate i mogu da obezbede bolju bioraspoloživost leka i/ili smanjenje jednog ili više neželjenih efekata udruženih sa primenom ciklosporina A. Takođe su opisani postupci za upotrebu i dobijanje formulacija.[The present invention relates to formulations containing cyclosporin analogs that are structurally similar to cyclosporin A, in particular isomeric mixtures of cyclosporin analogs that are structurally similar to cyclosporin A. The formulations form stable microemulsion preconcentrates and may provide superior drug bioavailability and/or may reduce one or more adverse effects associated with the administration of cyclosporin. Also disclosed are methods for using and preparing the formulations.
YU32904A2001-10-192002-10-17Novi analog ciklosporina za formiranje mikroemulzionih prekoncentrata
YU32904A
(sh)
A highly purified ifn – β active and mannitol-containing preparation, a method to make an improved stability of ifn – β active, and a method to enhance the stability of ifn – β in biologically active formulation.