ES2067452T3 - Rodomicinas semisinteticas, procedimiento para su preparacion y su empleo como citostaticos. - Google Patents

Rodomicinas semisinteticas, procedimiento para su preparacion y su empleo como citostaticos.

Info

Publication number
ES2067452T3
ES2067452T3 ES88105330T ES88105330T ES2067452T3 ES 2067452 T3 ES2067452 T3 ES 2067452T3 ES 88105330 T ES88105330 T ES 88105330T ES 88105330 T ES88105330 T ES 88105330T ES 2067452 T3 ES2067452 T3 ES 2067452T3
Authority
ES
Spain
Prior art keywords
formula
hydrogen
alpha
rhodosaminyl
acyl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88105330T
Other languages
English (en)
Inventor
Manfred Dr Gerken
Cenek Dr Kolar
Hans Peter Dr Kraemer
Dieter Dr Hoffmann
Peter Dr Hermentin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Application granted granted Critical
Publication of ES2067452T3 publication Critical patent/ES2067452T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

EL INVENTO SE TRATA DE ANTRACICLIN NUEVO, SITOESTATICO, EFICAZ DE LA FORMULA GENERAL I, QUE EN EL CASO DADO SE PRESENTA COMO SAL DE UN ACIDO ANORGANICO U ORGANICO, DONDE LOS RESIDUOS R1 SIGNIFICAN HIDROGENO O HIDROXI; R2 HIDROGENO, UNA ESTRUCTURA DE LA FORMULA II O IV O JUNTO CON R3 UNA ESTRUCTURA DE LA FORMULA III.; R3 SIGNIFICA HIDROGENO, UNA ESTRUCTURA DE LA FORMULA II O IV O JUNTO CON R2 UNA ESTRUCTURA DE LA FORMULA III; R4 ES HIDROGENO, UN GRUPO DE ACILO, TRIMETILOSILIL, UNA ESTRUCTURA DE LA FORMULA II O UNA ESTRUCTURA DE LA FORMULA IV: DONDE R5 ES HIDROGENO, METILO, HIDROXI, METILENO, R6 ES HIDROGENO, HIDROXI, ACILOXI, ALCOHILOXI, ALILOXI, BENCILOXI O HALOGEN. R7 SIGNIFICA LO MISMO QUE R6 Y PUEDE SER ADICIONALMENTE NH2, NH ACILO, N (ALCOHIL)3, N (CH2 (N)2, NH (CH2 CN) O ACIDO, R8 SIGNIFICA LO MISMO QUE R6, DONDE SE COGE LAS SIGUIENTES COMBINACIONES DE LA FORMULA I: 1.2. LO DERIVADO. 3.IL O SU 4'' = (ALFA) R2 = R3 = H1R4 = (ALFA) VADO. ADEMAS SE TRATA EL INVENTO DE UN PROCEDIMIENTO PARALA ELABORACION DE LA COMBINACION ASI COMO SU APLICACION EN MEDICAMENTOS.
ES88105330T 1987-04-11 1988-04-01 Rodomicinas semisinteticas, procedimiento para su preparacion y su empleo como citostaticos. Expired - Lifetime ES2067452T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873712350 DE3712350A1 (de) 1987-04-11 1987-04-11 Semisynthetische rhodomycine, verfahren zu ihrer herstellung und ihre verwendung als zytostatika

Publications (1)

Publication Number Publication Date
ES2067452T3 true ES2067452T3 (es) 1995-04-01

Family

ID=6325447

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88105330T Expired - Lifetime ES2067452T3 (es) 1987-04-11 1988-04-01 Rodomicinas semisinteticas, procedimiento para su preparacion y su empleo como citostaticos.

Country Status (12)

Country Link
EP (1) EP0286926B1 (es)
JP (1) JP2672965B2 (es)
KR (1) KR880012624A (es)
AT (1) ATE116991T1 (es)
AU (1) AU614954B2 (es)
CA (1) CA1340690C (es)
DE (2) DE3712350A1 (es)
DK (1) DK192388A (es)
ES (1) ES2067452T3 (es)
FI (1) FI90777C (es)
GR (1) GR3015231T3 (es)
PT (1) PT87193B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722698A1 (de) * 1987-07-09 1989-01-19 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
FR2630914A1 (fr) * 1988-05-04 1989-11-10 Hoechst Sa Laboratoires Nouveaux analogues du l-fucose, leur procede de preparation, application de ces analogues a la preparation de nouveaux glycals, anthracyclines obtenues a l'aide de ces glycals et utilisation desdites anthracyclines en tant que medicaments
FR2630915A1 (fr) * 1988-05-04 1989-11-10 Hoechst Lab Nouveaux glycals, anthracyclines obtenues a l'aide de ces glycals et utilisation desdites anthracyclines en tant que medicaments
DE3836122A1 (de) * 1988-10-22 1990-05-31 Behringwerke Ag Verfahren zur herstellung von 4-0-alkyl-rhodomycinen
DE3842836A1 (de) * 1988-12-20 1990-06-21 Behringwerke Ag Rhodomycine mit einer modifizierten kohlenhydrat-einheit
AU4752190A (en) * 1988-12-28 1990-08-01 Board Of Regents, The University Of Texas System 3'-deamino analogs of esorubicin and methods for their use
DE3920062A1 (de) * 1989-06-20 1991-01-10 Hoechst Ag Neue anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
TW202023625A (zh) 2018-08-23 2020-07-01 美商西雅圖遺傳學公司 抗tigit抗體

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2056443B (en) * 1979-08-20 1984-01-18 Hoffmann La Roche Cyclic compounds
US4302449A (en) * 1980-09-02 1981-11-24 Board Of Control Of Michigan Technological University Carminomycin analogue
GB2120667B (en) * 1982-05-24 1985-06-05 Erba Farmitalia Anthracycline glycosides
DE3323025A1 (de) * 1983-06-25 1985-01-10 Hoechst Ag, 6230 Frankfurt Anthracyclin-derivate, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika
DE3425357A1 (de) * 1984-07-10 1986-01-23 Hoechst Ag, 6230 Frankfurt 1-hydroxy-cytorhodine, ein mikrobiologisches verfahren zu ihrer herstellung und ihre verwendung als cytostatika
JPS6133194A (ja) * 1984-07-25 1986-02-17 Sanraku Inc 新規アントラサイクリン抗生物質
JPS61236792A (ja) * 1985-04-12 1986-10-22 Sanraku Inc 新規アントラサイクリン抗生物質
JPS62238298A (ja) * 1986-04-08 1987-10-19 Sanraku Inc 新規アントラサイクリン抗生物質ｄｃｐ−１及び２
JPS6391395A (ja) * 1986-10-03 1988-04-22 Kirin Brewery Co Ltd アンスラサイクリン化合物、その製造法およびその用途
DE3641835A1 (de) * 1986-12-08 1988-06-16 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
DE3641833A1 (de) 1986-12-08 1988-06-09 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate
JPS63227599A (ja) * 1987-03-14 1988-09-21 Kirin Brewery Co Ltd アンスラサイクリン化合物およびその用途
DE3722698A1 (de) * 1987-07-09 1989-01-19 Behringwerke Ag Zytostatisch wirksame anthracyclinderivate

Also Published As

Publication number Publication date
AU1446888A (en) 1988-10-13
JPS63267775A (ja) 1988-11-04
GR3015231T3 (en) 1995-05-31
DK192388A (da) 1988-10-12
PT87193A (pt) 1988-05-01
JP2672965B2 (ja) 1997-11-05
DK192388D0 (da) 1988-04-08
FI90777B (fi) 1993-12-15
KR880012624A (ko) 1988-11-28
FI881610A (fi) 1988-10-12
AU614954B2 (en) 1991-09-19
CA1340690C (en) 1999-08-03
ATE116991T1 (de) 1995-01-15
FI881610A0 (fi) 1988-04-07
EP0286926B1 (de) 1995-01-11
FI90777C (fi) 1994-03-25
EP0286926A2 (de) 1988-10-19
DE3712350A1 (de) 1988-10-20
DE3852711D1 (de) 1995-02-23
PT87193B (pt) 1992-07-31
EP0286926A3 (en) 1990-09-19

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