AU1446888A - Semi-synthetic rhodomycins, a process for their preparation and their use as cytostatics - Google Patents

Semi-synthetic rhodomycins, a process for their preparation and their use as cytostatics

Info

Publication number
AU1446888A
AU1446888A AU14468/88A AU1446888A AU1446888A AU 1446888 A AU1446888 A AU 1446888A AU 14468/88 A AU14468/88 A AU 14468/88A AU 1446888 A AU1446888 A AU 1446888A AU 1446888 A AU1446888 A AU 1446888A
Authority
AU
Australia
Prior art keywords
formula
hydrogen
alpha
rhodosaminyl
acyl derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU14468/88A
Other versions
AU614954B2 (en
Inventor
Manfred Gerken
Peter Hermentin
Dieter Hoffmann
Cenek Kolar
Hans Peter Kraemer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics GmbH Germany
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Publication of AU1446888A publication Critical patent/AU1446888A/en
Application granted granted Critical
Publication of AU614954B2 publication Critical patent/AU614954B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Novel cytostatically active anthracyclines of the formula I, which are optionally present as a salt of an inorganic or organic acid <IMAGE> in which the radical R<1> is hydrogen or hydroxyl, R<2> is hydrogen, a structure of the formula II or IV or together with R<3> is a structure of the formula III, R<3> is hydrogen, a structure of the formula II or IV or together with R<2> is a structure of the formula III, R<4> is hydrogen, an acyl group, trimethylsilyl, a structure of the formula II or a structure of the formula IV <IMAGE> R<5> in this case is hydrogen, methyl, hydroxymethylene, acyloxymethylene or alkyloxymethylene, R<6> is hydrogen, hydroxyl, acyloxy, alkyloxy, allyloxy, benzyloxy or halogen, R<7> has the same meaning as R<6> and can additionally be NH2, NHacyl, N(alkyl)3, N(CH2CN)2, NH(CH2CN) or azido, and R<8> has the same meaning as R<6>, where the following compounds of the formula I are excepted: 1. R<1>=R<3>=R<4>=H, R<2>= alpha -L-daunosaminyl 2. R<1>=R<3>=R<4>=H, R<2>= alpha -L-rhodosaminyl or its 4'-acyl derivatives 3. R<1>=R<3>=H, R<2>=R<4>= alpha -L-rhodosaminyl or its 4'-acyl derivatives 4. R<1>=OH, R<3>=H, R<2>=R<4>= alpha -L-rhodosaminyl or its 4'-acyl derivatives 5. R<1>=R<2>=R<3>=H, R<4>= alpha -L-rhodosaminyl or its 4'-acyl derivatives.
AU14468/88A 1987-04-11 1988-04-11 Semi-synthetic rhodomycins, a process for their preparation and their use as cytostatics Ceased AU614954B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3712350 1987-04-11
DE19873712350 DE3712350A1 (en) 1987-04-11 1987-04-11 SEMISYNTHETIC RHODOMYCINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS

Publications (2)

Publication Number Publication Date
AU1446888A true AU1446888A (en) 1988-10-13
AU614954B2 AU614954B2 (en) 1991-09-19

Family

ID=6325447

Family Applications (1)

Application Number Title Priority Date Filing Date
AU14468/88A Ceased AU614954B2 (en) 1987-04-11 1988-04-11 Semi-synthetic rhodomycins, a process for their preparation and their use as cytostatics

Country Status (12)

Country Link
EP (1) EP0286926B1 (en)
JP (1) JP2672965B2 (en)
KR (1) KR880012624A (en)
AT (1) ATE116991T1 (en)
AU (1) AU614954B2 (en)
CA (1) CA1340690C (en)
DE (2) DE3712350A1 (en)
DK (1) DK192388A (en)
ES (1) ES2067452T3 (en)
FI (1) FI90777C (en)
GR (1) GR3015231T3 (en)
PT (1) PT87193B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722698A1 (en) * 1987-07-09 1989-01-19 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES
FR2630914A1 (en) * 1988-05-04 1989-11-10 Hoechst Sa Laboratoires NOVEL ANALOGUES OF L-FUCOSE, PROCESS FOR THE PREPARATION THEREOF, APPLICATION OF THESE ANALOGUES TO THE PREPARATION OF NOVEL GLYCALS, ANTHRACYCLINES OBTAINED BY SAID GLYCALS AND USE OF SAID ANTHRACYCLINS AS MEDICAMENTS
FR2630915A1 (en) * 1988-05-04 1989-11-10 Hoechst Lab Novel glycals, anthracyclines obtained using these glycals and use of these anthracyclines as medicaments
DE3836122A1 (en) * 1988-10-22 1990-05-31 Behringwerke Ag METHOD FOR PRODUCING 4-0-ALKYL RHODOMYCINES
DE3842836A1 (en) * 1988-12-20 1990-06-21 Behringwerke Ag RHODOMYCINE WITH A MODIFIED CARBOHYDRATE UNIT
WO1990007519A1 (en) * 1988-12-28 1990-07-12 Board Of Regents, The University Of Texas System 3'-deamino analogs of esorubicin and methods for their use
DE3920062A1 (en) * 1989-06-20 1991-01-10 Hoechst Ag NEW ANTHRACYCLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
CA3107596A1 (en) 2018-08-23 2020-02-27 Seagen Inc. Anti-tigit antibodies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2056443B (en) * 1979-08-20 1984-01-18 Hoffmann La Roche Cyclic compounds
US4302449A (en) * 1980-09-02 1981-11-24 Board Of Control Of Michigan Technological University Carminomycin analogue
GB2120667B (en) * 1982-05-24 1985-06-05 Erba Farmitalia Anthracycline glycosides
DE3323025A1 (en) * 1983-06-25 1985-01-10 Hoechst Ag, 6230 Frankfurt ANTHRACYCLINE DERIVATIVES, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
DE3425357A1 (en) * 1984-07-10 1986-01-23 Hoechst Ag, 6230 Frankfurt 1-HYDROXY-CYTORHODINE, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
JPS6133194A (en) * 1984-07-25 1986-02-17 Sanraku Inc Novel anthracycline antibiotic substance
JPS61236792A (en) 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic
JPS62238298A (en) * 1986-04-08 1987-10-19 Sanraku Inc Novel anthracycline antibiotic substance dcp-1 and 2
JPS6391395A (en) * 1986-10-03 1988-04-22 Kirin Brewery Co Ltd Anthracycline compound, its production and use thereof
DE3641835A1 (en) * 1986-12-08 1988-06-16 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES
DE3641833A1 (en) * 1986-12-08 1988-06-09 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES
JPS63227599A (en) * 1987-03-14 1988-09-21 Kirin Brewery Co Ltd Anthracycline compound and use thereof
DE3722698A1 (en) * 1987-07-09 1989-01-19 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES

Also Published As

Publication number Publication date
EP0286926B1 (en) 1995-01-11
DK192388D0 (en) 1988-04-08
FI90777C (en) 1994-03-25
ES2067452T3 (en) 1995-04-01
EP0286926A3 (en) 1990-09-19
DK192388A (en) 1988-10-12
DE3712350A1 (en) 1988-10-20
EP0286926A2 (en) 1988-10-19
PT87193B (en) 1992-07-31
ATE116991T1 (en) 1995-01-15
DE3852711D1 (en) 1995-02-23
FI881610A (en) 1988-10-12
JP2672965B2 (en) 1997-11-05
KR880012624A (en) 1988-11-28
FI881610A0 (en) 1988-04-07
JPS63267775A (en) 1988-11-04
PT87193A (en) 1988-05-01
GR3015231T3 (en) 1995-05-31
AU614954B2 (en) 1991-09-19
CA1340690C (en) 1999-08-03
FI90777B (en) 1993-12-15

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Legal Events

Date Code Title Description
MK14 Patent ceased section 143(a) (annual fees not paid) or expired