FI881610A0 - Process for the preparation of cytostatically active -rodomycinone derivatives - Google Patents

Process for the preparation of cytostatically active -rodomycinone derivatives

Info

Publication number
FI881610A0
FI881610A0 FI881610A FI881610A FI881610A0 FI 881610 A0 FI881610 A0 FI 881610A0 FI 881610 A FI881610 A FI 881610A FI 881610 A FI881610 A FI 881610A FI 881610 A0 FI881610 A0 FI 881610A0
Authority
FI
Finland
Prior art keywords
formula
hydrogen
alpha
rhodosaminyl
acyl derivatives
Prior art date
Application number
FI881610A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI90777C (en
FI881610A (en
FI90777B (en
Inventor
Manfred Gerken
Cenek Kolar
Hans Peter Kraemer
Dieter Hoffmann
Peter Hermentin
Original Assignee
Behringwerke Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag filed Critical Behringwerke Ag
Publication of FI881610A0 publication Critical patent/FI881610A0/en
Publication of FI881610A publication Critical patent/FI881610A/en
Application granted granted Critical
Publication of FI90777B publication Critical patent/FI90777B/en
Publication of FI90777C publication Critical patent/FI90777C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel cytostatically active anthracyclines of the formula I, which are optionally present as a salt of an inorganic or organic acid <IMAGE> in which the radical R<1> is hydrogen or hydroxyl, R<2> is hydrogen, a structure of the formula II or IV or together with R<3> is a structure of the formula III, R<3> is hydrogen, a structure of the formula II or IV or together with R<2> is a structure of the formula III, R<4> is hydrogen, an acyl group, trimethylsilyl, a structure of the formula II or a structure of the formula IV <IMAGE> R<5> in this case is hydrogen, methyl, hydroxymethylene, acyloxymethylene or alkyloxymethylene, R<6> is hydrogen, hydroxyl, acyloxy, alkyloxy, allyloxy, benzyloxy or halogen, R<7> has the same meaning as R<6> and can additionally be NH2, NHacyl, N(alkyl)3, N(CH2CN)2, NH(CH2CN) or azido, and R<8> has the same meaning as R<6>, where the following compounds of the formula I are excepted: 1. R<1>=R<3>=R<4>=H, R<2>= alpha -L-daunosaminyl 2. R<1>=R<3>=R<4>=H, R<2>= alpha -L-rhodosaminyl or its 4'-acyl derivatives 3. R<1>=R<3>=H, R<2>=R<4>= alpha -L-rhodosaminyl or its 4'-acyl derivatives 4. R<1>=OH, R<3>=H, R<2>=R<4>= alpha -L-rhodosaminyl or its 4'-acyl derivatives 5. R<1>=R<2>=R<3>=H, R<4>= alpha -L-rhodosaminyl or its 4'-acyl derivatives.
FI881610A 1987-04-11 1988-04-07 Process for the preparation of cytostatically active -rodomycinone derivatives FI90777C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873712350 DE3712350A1 (en) 1987-04-11 1987-04-11 SEMISYNTHETIC RHODOMYCINES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
DE3712350 1987-04-11

Publications (4)

Publication Number Publication Date
FI881610A0 true FI881610A0 (en) 1988-04-07
FI881610A FI881610A (en) 1988-10-12
FI90777B FI90777B (en) 1993-12-15
FI90777C FI90777C (en) 1994-03-25

Family

ID=6325447

Family Applications (1)

Application Number Title Priority Date Filing Date
FI881610A FI90777C (en) 1987-04-11 1988-04-07 Process for the preparation of cytostatically active -rodomycinone derivatives

Country Status (12)

Country Link
EP (1) EP0286926B1 (en)
JP (1) JP2672965B2 (en)
KR (1) KR880012624A (en)
AT (1) ATE116991T1 (en)
AU (1) AU614954B2 (en)
CA (1) CA1340690C (en)
DE (2) DE3712350A1 (en)
DK (1) DK192388A (en)
ES (1) ES2067452T3 (en)
FI (1) FI90777C (en)
GR (1) GR3015231T3 (en)
PT (1) PT87193B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722698A1 (en) * 1987-07-09 1989-01-19 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES
FR2630914A1 (en) * 1988-05-04 1989-11-10 Hoechst Sa Laboratoires NOVEL ANALOGUES OF L-FUCOSE, PROCESS FOR THE PREPARATION THEREOF, APPLICATION OF THESE ANALOGUES TO THE PREPARATION OF NOVEL GLYCALS, ANTHRACYCLINES OBTAINED BY SAID GLYCALS AND USE OF SAID ANTHRACYCLINS AS MEDICAMENTS
FR2630915A1 (en) * 1988-05-04 1989-11-10 Hoechst Lab Novel glycals, anthracyclines obtained using these glycals and use of these anthracyclines as medicaments
DE3836122A1 (en) * 1988-10-22 1990-05-31 Behringwerke Ag METHOD FOR PRODUCING 4-0-ALKYL RHODOMYCINES
DE3842836A1 (en) * 1988-12-20 1990-06-21 Behringwerke Ag RHODOMYCINE WITH A MODIFIED CARBOHYDRATE UNIT
WO1990007519A1 (en) * 1988-12-28 1990-07-12 Board Of Regents, The University Of Texas System 3'-deamino analogs of esorubicin and methods for their use
DE3920062A1 (en) * 1989-06-20 1991-01-10 Hoechst Ag NEW ANTHRACYCLINE DERIVATIVES, A METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
WO2020041541A2 (en) 2018-08-23 2020-02-27 Seattle Genetics, Inc. Anti-tigit antibodies

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2056443B (en) * 1979-08-20 1984-01-18 Hoffmann La Roche Cyclic compounds
US4302449A (en) * 1980-09-02 1981-11-24 Board Of Control Of Michigan Technological University Carminomycin analogue
GB2120667B (en) * 1982-05-24 1985-06-05 Erba Farmitalia Anthracycline glycosides
DE3323025A1 (en) * 1983-06-25 1985-01-10 Hoechst Ag, 6230 Frankfurt ANTHRACYCLINE DERIVATIVES, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
DE3425357A1 (en) * 1984-07-10 1986-01-23 Hoechst Ag, 6230 Frankfurt 1-HYDROXY-CYTORHODINE, A MICROBIOLOGICAL METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS CYTOSTATICS
JPS6133194A (en) * 1984-07-25 1986-02-17 Sanraku Inc Novel anthracycline antibiotic substance
JPS61236792A (en) 1985-04-12 1986-10-22 Sanraku Inc Novel anthracycline antibiotic
JPS62238298A (en) * 1986-04-08 1987-10-19 Sanraku Inc Novel anthracycline antibiotic substance dcp-1 and 2
JPS6391395A (en) * 1986-10-03 1988-04-22 Kirin Brewery Co Ltd Anthracycline compound, its production and use thereof
DE3641835A1 (en) * 1986-12-08 1988-06-16 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES
DE3641833A1 (en) * 1986-12-08 1988-06-09 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES
JPS63227599A (en) * 1987-03-14 1988-09-21 Kirin Brewery Co Ltd Anthracycline compound and use thereof
DE3722698A1 (en) * 1987-07-09 1989-01-19 Behringwerke Ag CYTOSTATICALLY EFFECTIVE ANTHRACYCLINE DERIVATIVES

Also Published As

Publication number Publication date
KR880012624A (en) 1988-11-28
GR3015231T3 (en) 1995-05-31
DE3852711D1 (en) 1995-02-23
FI90777C (en) 1994-03-25
FI881610A (en) 1988-10-12
EP0286926B1 (en) 1995-01-11
PT87193B (en) 1992-07-31
AU614954B2 (en) 1991-09-19
DE3712350A1 (en) 1988-10-20
JP2672965B2 (en) 1997-11-05
PT87193A (en) 1988-05-01
JPS63267775A (en) 1988-11-04
DK192388A (en) 1988-10-12
ATE116991T1 (en) 1995-01-15
CA1340690C (en) 1999-08-03
ES2067452T3 (en) 1995-04-01
EP0286926A2 (en) 1988-10-19
FI90777B (en) 1993-12-15
EP0286926A3 (en) 1990-09-19
AU1446888A (en) 1988-10-13
DK192388D0 (en) 1988-04-08

Similar Documents

Publication Publication Date Title
ES8405795A1 (en) Process for producing beta-carboline derivatives.
ES8702427A1 (en) 2-Substituted-1,3-propylidenediphosphonate derivatives, the process for their preparation and pharmaceutical compositions containing them.
FI881610A (en) Process for the preparation of cytostatically active -rodomycinone derivatives
EP0214664A3 (en) Process for the preparation of organopolysilanes and use of the organopolysilanes thus obtained
MY109628A (en) An improved proces for the preparation of substituted indoline derivatives
KR890009962A (en) Manimicin derivatives, preparation methods and uses thereof
SE8600046D0 (en) USE OF ESTER COMPOUND AS A TEMPORARY BACTERICIDE AND PRODUCT CONTAINING SAID ESTER COMPOUND
GR3017571T3 (en) 2&#39;-fluorofuranosyl derivatives and novel method of preparing 2&#39;-fluoropyrimidine and 2&#39;-fluoropurine nucleosides.
IE830225L (en) Imidazolidines
RO87991A (en) PROCESS FOR THE PREPARATION OF TIAZOLIDIN ESTERS SUBSTITUTED BY MINERAL ACIDS
JPS5538301A (en) New derivative of antibiotics fortimicin and its preparation
CA1273347C (en)
DE3477003D1 (en) Process for the preparation of 17-alpha-acyloxy-6-chloro-1-alpha,2-alpha-methylene-4,6-pregnadiene-3-20-diones
JPS6431791A (en) Production of monohydrogen (triorganosiloxy) organosilane
KR880002879A (en) (5R, 6S, 8R) -6- (1-hydroxyethyl) -2- (3R-pyrrolidin-2-one-3-yl) thiophenem-3-carboxylic acid
ES8500909A1 (en) Benzimidazole derivatives
DE3175939D1 (en) Use of gamma-piperidino-butyrophenones for the preparation of medicaments for treating diarrhoea
PT78364B (en) Process for preparing iminosulphonamides from pharmaceutic preparation wich contain these compounds and its therapeutical utilization
NZ222427A (en) 4-hydroxy-4-(substituted alkenyl)-cyclohexanecarboxylic acid derivatives and preparatory processes
JPS57142916A (en) Antitumor agent
ES481750A1 (en) (1-Alkyl-5-nitro-2-imidazolyl)-vinyl-glyoxal-diacetals, their preparation and their use
JPS56150080A (en) Formimidoylistamycin b and its preparation
JPS6479196A (en) Novel anthracycline derivative
JPS5528916A (en) 5-fluorouracil derivative and its preparation
JPS6475485A (en) Bisnitrourea derivative and antitumor agent

Legal Events

Date Code Title Description
BB Publication of examined application
FG Patent granted

Owner name: BEHRINGWERKE AKTIENGESELLSCHAFT

MA Patent expired